Design, synthesis, and in‐silico study of novel triarylethylene analogs with dual anti‐estrogenic and serotonergic activity

Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer

(2023) Lilan Xin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Serotoninergic receptor ligands improve Tamoxifen effectiveness on breast cancer cells

(2022) Maria Rosaria Ambrosio et al.   BMC CANCER

Flexible Etherified and Esterified Triphenylethylene Derivatives and Their Evaluation on ER‐positive and Triple‐Negative Breast Cancer Cell Lines

(2022) Aya S. Hassan et al.   ChemMedChem

Design, synthesis, and metabolite identification of Tamoxifen esterase-activatable prodrugs

(2022) Rahma M. Elbagoury et al.   BIOORGANIC CHEMISTRY

Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer

(2021) Jessica Caciolla et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel flexible tamoxifen analogues to overcome CYP2D6 polymorphism and their biological evaluation on MCF‐7 cell line

(2020) Nermin S. Ahmed et al.   DRUG DEVELOPMENT RESEARCH

Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine

(2019) Kanako Terakado Kimura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively

(2019) Mauro Sola-Penna et al.   BRITISH JOURNAL OF CANCER

5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

(2018) Yao Peng et al.   CELL

The Role of 5-HT1A Receptor in the Cancer as a New Opportunity in Medicinal Chemistry

(2018) Angela Corvino et al.   CURRENT MEDICINAL CHEMISTRY

The role of 5 HT6-receptor antagonists in Alzheimer’s disease: an update

(2018) Rita Khoury et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer

(2018) Philipp Y. Maximov et al.   MOLECULAR PHARMACOLOGY

Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism

(2016) Nermin S. Ahmed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel flexible ester-containing analogs of tamoxifen and their evaluation as anticancer agents

(2016) Nehal H Elghazawy et al.   Future Medicinal Chemistry

Serotonin and Cancer: What Is the Link?

(2015) D. Sarrouilhe et al.   CURRENT MOLECULAR MEDICINE

Tamoxifen Use in Postmenopausal Breast Cancer: CYP2D6 Matters

(2012) Hiltrud Brauch et al.   JOURNAL OF CLINICAL ONCOLOGY

Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines

(2012) Xia Xu et al.   Genome Medicine

The hydrolytic activity of esterases in the yeastSaccharomyces cerevisiaeis strain dependent

(2011) Magdalena Kwolek‑Mirek et al.   CELL BIOLOGY INTERNATIONAL

Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands

(2011) Philippe de Medina et al.   CHEMISTRY AND PHYSICS OF LIPIDS