4.7 Article

Rh-catalyzed oxidizing group-directed ortho C-H vinylation of arenes by vinylstannanes

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 69, Pages 13362-13364

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04211a

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Funding

  1. Ministry of Science and Technology of the Republic of China [MOST-103-2633-M-007-001]

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An efficient method for the synthesis of functionalized vinyl arenes from the reaction of N-methoxybenzamides or N-phenoxyacetamides with vinylstannanes via rhodium(III)-catalyzed C-H activation is described. The application of the methodology for the synthesis of a natural product thalactamine and a 7-membered ring oxepine are also demonstrated.

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