Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 7, Pages 1263-1266Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08594a
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Funding
- European Research Council (ERC) [320493]
- China Scholarship Council
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An NHC-catalyzed regio- and stereoselective Mannich/lactamization domino reaction of N-(benzothiazolyl)imines with alpha-chloroaldehydes has been developed. This new protocol provides a facile approach for the asymmetric synthesis of benzothiazolo-pyrimidinones and a pyrrolo[1,2-a] indolone in moderate to good yields (34-78%) and excellent stereoselectivities (87-99% ee, up to > 20 : 1 d.r.).
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