Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Carina Goetestam Skorpen, Stian Lydersen, Kjell Asmund Salvesen, Hege Suorza Svean Koksvik, Bente Jakobsen, Marianne Wallenius
Summary: This study analyzed the pregnancy outcomes of women with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). The results showed that active inflammation increased the risk of cesarean section, which delayed recovery from inflammatory pain and stiffness.
Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Clementina Lopez-Medina, Anna Molto, Joachim Sieper, Tuncay Duruoz, Uta Kiltz, Bassel Elzorkany, Najia Hajjaj-Hassouni, Ruben Burgos-Vargas, Jose Maldonado-Cocco, Nelly Ziade, Meghna Gavali, Victoria Navarro-Compan, Shue-Fen Luo, Sara Monti, Kim Tae-Jong, Mitsumasa Kishimoto, F. M. Pimentel-Santos, Jieruo Gu, Ruxandra Schiotis, Floris A. van Gaalen, Pal Geher, Marina Magrey, Sebastian E. Ibanez Vodnizza, Wilson Bautista-Molano, Walter Maksymowych, Pedro M. Machado, Robert Landew, Desiree van der Heijde, Maxime Dougados
Summary: This study included 4465 patients with SpA from 24 countries around the world, showing quantitative differences in peripheral manifestations among different subtypes but no significant qualitative differences. It was found that a high proportion of patients with SpA had both axial and peripheral manifestations coinciding.
Review
Microbiology
Tianwen Huang, Yaoyu Pu, Xiangpeng Wang, Yanhong Li, Hang Yang, Yubin Luo, Yi Liu
Summary: Spondyloarthritis (SpA) is a rheumatic disease that causes joint inflammation. Metabolomic profiling studies have provided insights into etiological factors and biomarkers for SpA.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Ophthalmology
Nazife Sule Yasar Bilge, Umut Kalyoncu, Pamir Atagunduz, Ediz Dalkilic, Yavuz Pehlivan, Orhan Kucuksahin, Cemal Bes, Servet Akar, Muhammet Cinar, Hakan Emmungil, Duygu Ersozlu, Askin Ates, Ridvan Mercan, Gezmis Kimyon, Suleyman Serdar Koca, Emel Gonullu, Veli Yazisiz, Emre Tekgoz, Nilufer Alpay-Kanitez, Abdulsamet Erden, Sedat Kiraz, Belkis Nihan Coskun, Burcu Yagiz, Ufuk Ilgen, Omer Karadag, Levent Kilic, Ihsan Ertenli, Timucin Kasifoglu
Summary: The study aimed to analyze the frequency and factors associated with acute anterior uveitis (AAU) in different forms of Spondyloarthritis (SpA) in a large Turkish cohort. It was found that older age, smoking history, delayed diagnosis, longer disease duration, arthritis, positive HLA-B27, family history of SpA, and radiographic damage were associated with a higher prevalence of uveitis in SpA patients. Psoriasis and psoriatic arthritis patients had a lower prevalence of uveitis. Early detection of uveitis can aid in the diagnosis of SpA.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Summary: This study aimed to describe the real-world use of Secukinumab (SEC) in Canadian patients with axSpA. The results showed that SEC was effective in treating axSpA, with improvements in disease activity observed in patients after 12 months of treatment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Maria-Sole Chimenti, Rieke Alten, Maria-Antonieta D'Agostino, Elisa Gremese, Uta Kiltz, Ennio Lubrano, Mireia Moreno, Thao Pham, Roberta Ramonda, Francesca-Romana Spinelli, Chiara Perella, Laura Andreoli
Summary: Emerging evidence suggests that axial spondyloarthritis (axSpA) occurs with roughly equal frequency in women and men, but they experience the disease differently. Female patients often face longer diagnostic delays and greater limitations in physical function, leading to lower treatment adherence.
Review
Rheumatology
Varun Dhir, Debasish Mishra, Joydeep Samanta
Summary: Although studies on systemic and local injections of GCs in SpA are limited, there is evidence of efficacy with high-dose systemic GCs in the short term (<= 6 months). Both IA and entheseal injections appear to be safe and effective.
Article
Rheumatology
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Tomita, Hironori Nakagami
Summary: This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats. The results showed that the IL17A peptide-based vaccine successfully induced antibody production and suppressed the arthritis score and joint thickness. It also inhibited enthesitis, bone destruction, and new bone formation. The study suggests that the IL17A peptide-based vaccine may be a therapeutic option for SpA treatment.
Article
Health Care Sciences & Services
Helena Santos, Ana Rita Henriques, Jaime Branco, Pedro M. Machado, Helena Canhao, Fernando M. Pimentel-Santos, Ana Maria Rodrigues
Summary: The study found that both spondyloarthritis and chronic low back pain have similar impacts on health-related quality of life (HRQoL), including mental, physical, and social domains. Patients with spondyloarthritis and chronic low back pain reported significantly lower HRQoL compared to those without rheumatic diseases. Modifiable factors such as multimorbidity, active disease, obesity, and regular physical exercise were associated with HRQoL in these conditions.
QUALITY OF LIFE RESEARCH
(2023)
Article
Rheumatology
Josef S. Smolen, Robert B. M. Landewe, Sytske Anne Bergstra, Andreas Kerschbaumer, Alexandre Sepriano, Daniel Aletaha, Roberto Caporali, Christopher John Edwards, Kimme L. Hyrich, Janet E. Pope, Savia de Souza, Tanja A. Stamm, Tsutomu Takeuchi, Patrick Verschueren, Kevin L. Winthrop, Alejandro Balsa, Joan M. Bathon, Maya H. Buch, Gerd R. Burmester, Frank Buttgereit, Mario Humberto Cardiel, Katerina Chatzidionysiou, Catalin Codreanu, Maurizio Cutolo, Alfons A. den Broeder, Khadija El Aoufy, Axel Finckh, Joao Eurico Fonseca, Jacques-Eric Gottenberg, Espen A. Haavardsholm, Annamaria Iagnocco, Kim Lauper, Zhanguo Li, Iain B. McInnes, Eduardo F. Mysler, Peter Nash, Gyula Poor, Gorica G. Ristic, Felice Rivellese, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Nikolay Stoilov, Anja Strangfeld, Annette van der Helm-van Mil, Elsa van Duuren, Theodora P. M. Vliet Vlieland, Rene Westhovens, Desiree van der Heijde
Summary: This study provides an update on the management recommendations for rheumatoid arthritis (RA) based on the latest developments in the field. The recommendations cover various aspects including medication use, combination therapy, treatment strategies, and dose reduction. The consensus was reached on 5 overarching principles and 11 specific recommendations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Biographical-Item
Endocrinology & Metabolism
Vanda Jorgetti, Sampaio-Barros Pd, Shinjo Sk, Eloisa Bonfa
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Acoustics
Joao Janeiro, Sofia Barreira, Patricia Martins, Marco Sarmento, Jorge Campos, Joao Eurico Fonseca
Summary: This study aimed to identify ultrasound prognostic factors for shoulder pain. The findings showed that a positive Doppler signal on shoulder tendons and absent tendon heterogeneity were associated with improvement reported by the patients. Poorly defined and sparsely distributed calcifications were also indicators of a better disease course.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Rheumatology
Marilia M. Sampaio-Barros, Adriana B. Bortoluzzo, Henrique Carrico da Silva, Ana Paula Luppino-Assad, Rosa Maria R. Pereira, Percival D. Sampaio-Barros
Summary: This case-control study analyzed the risk factors for symptomatic fractures in patients with systemic sclerosis. The results showed that symptomatic fractures were significantly associated with lower lumbar spine bone mineral density, use of high doses of corticosteroids, and bisphosphonates.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Joao Pedro Ferreira, Adelino Leite-Moreira, Altamiro da Costa-Pereira, Antonio Jose Soares, Carlos Robalo-Cordeiro, Carmen Jeronimo, Cristina Gavina, Fausto J. Pinto, Fernando Schmitt, Francisca Saraiva, Francisco Vasques-Novoa, Helena Canhao, Henrique Cyrne-Carvalho, Isabel Palmeirim, Joana Pimenta, Joao Eurico Cabral Da Fonseca, Joao Firmino-Machado, Jorge Correia Pinto, Lino Goncalves, Miguel Castelo Branco, Nuno Sousa, Ricardo Fontes de Carvalho, Teresa Machado Luciano, Tiago Gil Oliveira, Catarina Resende Oliveira
Summary: Portugal has a chronic problem of underfunding in scientific research. Despite increasing national investment in recent years, it is still significantly insufficient. Clinical medicine, immunology, and multicenter epidemiological and cohort studies, which have huge potential for return on investment in clinical trials, are not given priority in the National Health Plan in Portugal, and researcher initiated studies in these fields are underfunded.
ACTA MEDICA PORTUGUESA
(2023)
Article
Ophthalmology
Ines Leal, Vanda Nogueira, Diogo Bernardo Matos, Joana Araujo, Olga Berens, Margarida Ribeiro, Maria Joao Furtado, Marco Liverani, Marta Ines Silva, Marta Guedes, Miguel Cordeiro, Miguel Ribeiro, Patricia Jose, Rafael Barao, Rui Nunes Ferreira, Sofia Fonseca, Sofia Mano, Susana Pina, Maria Jose Santos, Joao Eurico Fonseca, Cristina Fonseca, Luis Figueira
Summary: This paper introduces a innovative nationwide electronic medical record platform for uveitis called Uveite.pt, developed by the Portuguese Ocular Inflammation Group. It provides useful information for both clinical practice and real-world-based research, and presents an overview of the registered cohort since its establishment in March 2020.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Immunology
Matilde Bandeira, Eduardo Dourado, Ana Teresa Melo, Patricia Martins, Vanessa Fraga, Jose Luis Ferraro, Andre Saraiva, Marlene Sousa, Hugo Parente, Catarina Soares, Ana Margarida Correia, Diogo Esperanca Almeida, Sara Paiva Dinis, Ana Sofia Pinto, Filipe Oliveira Pinheiro, Maria Seabra Rato, Tiago Beirao, Beatriz Samoes, Bernardo Santos, Carolina Mazeda, Ana Teodosio Chicharo, Margarida Faria, Agna Neto, Maria Helena Lourenco, Luisa Brites, Marilia Rodrigues, Joana Silva-Dinis, Joao Madruga Dias, Filipe C. Araujo, Nadia Martins, Maura Couto, Ana Valido, Maria Jose Santos, Sofia Carvalho Barreira, Joao Eurico Fonseca, Raquel Campanilho-Marques
Summary: This study found that anti-SRP antibodies were predictors of cardiac involvement in IIM patients, regardless of demographic characteristics and lung involvement. Frequent screening for heart involvement is suggested in anti-SRP-positive IIM patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Ana Teresa Melo, Eduardo Dourado, Raquel Campanilho-Marques, Matilde Bandeira, Sofia C. Barreira, Jose Costa, Rita Pimenta, Sofia Antunes-Duarte, Ines Cordeiro, Joao E. Fonseca
Summary: Idiopathic inflammatory myopathies (IIM) are rare diseases characterized by chronic skeletal muscle inflammation and involvement of other organs. A multidisciplinary approach is crucial for the diagnosis and follow-up of these patients.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Rheumatology
Andre Silva Franco, Gabriel Berlingieri Polho, Ana Paula Luppino Assad, Renata Miossi, Percival Degrava Sampaio-Barros
Summary: This case report presents a patient with systemic sclerosis and multiple myeloma who experienced severe digital ischaemia that led to amputation of several fingers. The association between systemic sclerosis and multiple myeloma is rare, but should be considered in cases of significant worsening of Raynaud's phenomenon.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Letter
Rheumatology
Clementina Lopez-Medina, Antonio Doblas, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Helena Santos, Ana R. Henriques, Pedro M. Machado, Clementina Lopez-Medina, Maxime Dougados, Helena Canhao, Ana M. Rodrigues, Fernando Pimentel-Santos
Summary: The study identifies the determinants of health-related quality of life and global functioning and health in patients with axial SpA, peripheral SpA, and PsA. Disease activity and physical function were found to be major factors influencing HRQoL and GH across different types of SpA. Clinical characteristics and sociodemographic factors also play an important role, highlighting the importance of a holistic approach for individual patients.
Review
Rheumatology
A. M. Duarte-Monteiro, E. Dourado, J. E. Fonseca, F. Saraiva
Summary: Intra-articular glucocorticoid injection (IAGCI) is commonly used for treating joint pain and inflammation, but detailed descriptions of its safety are lacking. This review summarizes the complications of IAGCI in the short-term, immediate and long-term, as well as their predictors. Most studies primarily report mild adverse events with a similar incidence to placebo. However, reported incidences vary significantly and are mostly based on retrospective data. Septic arthritis is the most concerning complication due to its high mortality rate. Other local complications include injection site pain, post-injection flare, skin hypopigmentation and atrophy, and tendon rupture. Systemic side effects are also common, including vasovagal reactions, flushing, increased appetite and mood changes, hyperglycemia in diabetic patients, and bleeding in high-risk patients. There is limited evidence on predictors of complications. Overall, more detailed knowledge of adverse events and complications is needed given the routine use of IAGCI.
Article
Rheumatology
R. Talarico, G. A. Ramirez, S. C. Barreira, C. Cardamone, P. Triggianese, S. Aguilera, J. Andersen, T. Avcin, K. Benistan, G. Bertsias, A. Bortoluzzi, C. Bouillot, I. Bulina, G. R. Burmester, S. Callens, P. E. Carreira, R. Cervera, M. Cutolo, L. Damian, E. Della Torre, R. Faria, J. E. Fonseca, I. Galetti, E. Hachulla, L. Iaccarino, S. Jacobsen, N. Khmelinskii, M. Limper, D. Marinello, A. Meyer, G. Moroncini, G. Nagy, M. Olesinska, C. Pamfil, M. Pileckyte, M. Pistello, S. Rednic, C. Richez, V. C. Romao, M. Schneider, S. Sciascia, C. A. Scire, G. Simonini, V. Smith, A. Sulli, C. Tani, S. W. Tas, A. Tincani, M. C. Vonk, M. Tektonidou, M. Mosca
Summary: Recent studies have shown that immunocompromised individuals may inadvertently contribute to the mutations of the virus that lead to new variants. This aspect should be carefully considered as immunocompromised individuals remain at risk of COVID-19 despite vaccination, experience more severe disease, and can be contagious for longer. The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ReCONNET) addressed this issue by forming a multidisciplinary Task Force to develop guidelines for treating immunocompromised patients with COVID-19. The final principles and points-to-consider were agreed upon by the Task Force.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Jucier Goncalves Junior, Naoki Mugii, Pleiades Tiharu Inaoka, Renata Miossi, Fernando Henrique Carlos De Souza, Joao Calvino Soares De Oliveira, Fujiko Someya, Yasuhito Hamaguchi, Takashi Matsushita, Percival Degrava Sampaio-Barros, Samuel Katsuyuki Shinjo
Summary: This study describes and compares the demographic, clinical, and laboratory characteristics of patients with Myo-SSc from two tertiary centers. The study found that Myo-SSc mainly affects middle-aged women and the manifestation spectrum varies according to geographic distribution.
ARCHIVES OF RHEUMATOLOGY
(2023)