Article
Surgery
Bo Wei, Zongheng Zheng, Jiafeng Fang, Jian'an Xiao, Fanghai Han, Meijin Huang, Qingwen Xu, Xiaozhong Wang, Chuyuan Hong, Gongping Wang, Yongle Ju, Guoqiang Su, Haijun Deng, Jinxin Zhang, Jun Li, Tufeng Chen, Yong Huang, Jianglong Huang, Jianpei Liu, Xiaofeng Yang, Hongbo Wei
Summary: In male patients with rectal cancer, preserving Denonvilliers' fascia during L-TME surgery has been shown to have a better outcome on postoperative urogenital function compared to resection, reducing the incidence of urinary and sexual dysfunction.
Editorial Material
Gastroenterology & Hepatology
Sung Uk Bae, Cristopher Varela, Manar Nassr, Nam Kyu Kim
Summary: Selective anterior dissection in front of Denonvilliers' fascia can be performed during total mesorectal excision based on preoperative planning, tumor location, and clinical tumor stage. Preoperative MRI and magnified operative views in minimally invasive platforms provide access to more precise surgical planes for clear circumferential resection, achieving optimal functional outcomes and oncological safety.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Surgery
Kai Li, Pengcheng Pang, Hua Cheng, Junjie Zeng, Xiaobo He, Fengyu Cao, Qiang Luo, Shilun Tong, Yongbin Zheng
Summary: This study aimed to investigate the protective effect of laparoscopic functional total mesorectum excision (TME) on urinary and sexual functions in male patients with rectal cancer. The results showed that functional TME surgery was beneficial to faster recovery of urinary and sexual function for patients.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Hailong Liu, Yi Chang, Ajian Li, Wenchao Wang, Liang Lv, Jian Peng, Zhihui Pan, Huihong Jiang, Moubin Lin
Summary: This study demonstrates the feasibility and effectiveness of laparoscopic TME with UGF preservation for mid-low rectal cancer, providing better protection for urinary and sexual functions.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Henry H. Chill, Shani Y. Parnasa, Noam Shussman, Roie Alter, Briggite Helou, Adiel Cohen, Alon J. Pikarsky, David Shveiky
Summary: This study compared urinary dysfunction and its impact on quality of life in women who underwent total mesorectal excision versus partial mesorectal excision for rectal cancer treatment. The results showed no significant difference in urinary dysfunction or its influence on quality of life between the two groups. Prolonged hospital stay was associated with increased risk of urinary dysfunction to some degree, according to multivariate analysis.
Article
Surgery
Jingqing Ren, Shaojie Liu, Huixing Luo, Bailin Wang, Fan Wu
Summary: There was no significant difference in short-term efficacy between TaTME and LaTME for low rectal cancer, but TaTME had a longer operation time and a greater circumferential resection margin distance.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Ziwei Zeng, Zhihang Liu, Shuangling Luo, Zhenxing Liang, Liang Huang, Lei Ruan, Junji Chen, Haiqing Jie, Wenfeng Liang, Huashan Liu, Liang Kang
Summary: There were no significant differences in the 3-year local recurrence rate between the taTME and laTME groups. Additionally, the disease-free survival and overall survival rates within 3 years after surgery were also similar between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Antonio Caycedo-Marulanda, Lawrence Lee, Sami A. Chadi, Chris P. Verschoor, Jordan Crosina, Shady Ashamalla, Carl J. Brown
Summary: The study found that transanal TME performed by experienced surgeons had a low incidence of local recurrence and systemic recurrence, suggesting it may be an acceptable approach for rectal cancer management.
Article
Medicine, General & Internal
Andrea Cercek, Melissa Lumish, Jenna Sinopoli, Jill Weiss, Jinru Shia, Michelle Lamendola-Essel, Imane H. El Dika, Neil Segal, Marina Shcherba, Ryan Sugarman, Zsofia Stadler, Rona Yaeger, J. Joshua Smith, Benoit Rousseau, Guillem Argiles, Miteshkumar Patel, Avni Desai, Leonard B. Saltz, Maria Widmar, Krishna Iyer, Janie Zhang, Nicole Gianino, Christopher Crane, Paul B. Romesser, Emmanouil P. Pappou, Philip Paty, Julio Garcia-Aguilar, Mithat Gonen, Marc Gollub, Martin R. Weiser, Kurt A. Schalper, Luis A. Diaz
Summary: This study found that mismatch repair-deficient, locally advanced rectal cancer is highly sensitive to PD-1 blockade. Additionally, no adverse events of grade 3 or higher have been reported, and no cases of progression or recurrence have been observed. Longer follow-up is needed to assess the duration of response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Surgery
Vicente Simo, Patricia Tejedor, Luis Miguel Jimenez, Cristina Hernan, Jaime Zorilla, Jorge Arrredondo, Fernando Lapuente, Carlos Pastor
Summary: This study evaluated the mid-term oncological impact of TaTME for treating rectal cancer and showed positive outcomes at 2 years of follow-up. However, there is a lack of evidence in the literature regarding TaTME and oncological outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Swapnil Patel, Mufaddal Kazi, Ashwin L. Desouza, Vivek Sukumar, Jayesh Gori, Munita Bal, Avanish Saklani
Summary: Patients with positive pCRM have high rates of local and distal relapse, with systemic relapse often being detected through follow-up surveillance, while peritoneal or local relapse is more often symptomatic.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Review
Health Care Sciences & Services
Simona Giuratrabocchetta, Giampaolo Formisano, Adelona Salaj, Enrico Opocher, Luca Ferraro, Francesco Toti, Paolo Pietro Bianchi
Summary: Minimally invasive treatment of rectal cancer with Total Mesorectal Excision is complex and challenging, with robotic surgery offering advantages in dexterity but cost and benefits still need further evaluation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Surgery
Ivy H. Gardner, Katherine A. Kelley, Walaa F. Abdelmoaty, Ahmed Sharata, Amanda V. Hayman, Mark H. Whiteford
Summary: This study retrospectively analyzed 44 patients with mid and low rectal cancer who underwent low anterior resection via taTME. The results showed that 91% of TME specimens were graded as complete or near complete, with a post-operative complication rate of 18.2% and a local recurrence rate of 4.5%. This indicates that using the taTME approach can yield comparably safe and effective outcomes to laparoscopic proctectomy in technically complex cases.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Sapho Xenia Roodbeen, Antonino Spinelli, Willem A. Bemelman, Francesca Di Candido, Maylis Cardepont, Quentin Denost, Andre D'Hoore, Bert Houben, Joep J. Knol, Beatriz Martin-Perez, Eric Rullier, Dana Sands, Ilana Setton, Katrien Van de Steen, Pieter J. Tanis, Steven D. Wexner, Roel Hompes, Albert M. Wolthuis
Summary: This study aimed to determine the local recurrence (LR) rate and patterns after transanal total mesorectal excision (TaTME) for rectal cancer. The results showed good locoregional control after TaTME in selected cases from tertiary referral centers and did not indicate an inherent oncological risk of the surgical technique.
Article
Surgery
Han Beol Jang, Sang-Bum Kang, Hyein Lee, Byung Jo Choi, Sang Chul Lee
Summary: The study found no significant differences in the occurrence of anastomotic leakage and chronic presacral sinus between Transanal Total Mesorectal Excision (taTME) and Laparoscopic TME (lapTME) in rectal cancer patients. Almost one-third of anastomotic leakages developed into chronic presacral sinus.
ASIAN JOURNAL OF SURGERY
(2022)
Review
Surgery
PuRun Lei, Ying Ruan, Xiaofeng Yang, Jiafeng Fang, Tufeng Chen
INTERNATIONAL JOURNAL OF SURGERY
(2018)
Article
Biochemistry & Molecular Biology
Weiping Guo, Jianglong Huang, Purun Lei, Longbin Guo, Xi Li
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Surgery
Wenchao Li, Pinzhu Huang, Purun Lei, Hui Luo, Zhicheng Yao, Zhiyong Xiong, Bo Liu, Kunpeng Hu
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2019)
Article
Medicine, General & Internal
Pu-Run Lei, Jing-Wen Liao, Ying Ruan, Xiao-Feng Yang, Kun-Peng Hu, Jian-Pei Liu, Tu-Feng Chen
CHINESE MEDICAL JOURNAL
(2020)
Article
Oncology
Purun Lei, Ying Ruan, Lei Tan, Hongbo Wei, Tufeng Chen
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2020)
Article
Oncology
Purun Lei, Ying Ruan, Xiaofeng Yang, Juekun Wu, Yujie Hou, Hongbo Wei, Tufeng Chen
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Purun Lei, Ying Ruan, Jianpei Liu, Qixian Zhang, Xiao Tang, Juekun Wu
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2020)
Article
Engineering, Biomedical
Chenghua Liang, Xiangyang Bai, Cuiling Qi, Qingxue Sun, Xiaoyan Han, Tianyun Lan, Haibo Zhang, Xiaoming Zheng, Rongpu Liang, Ju Jiao, Zongheng Zheng, Jiafeng Fang, Purun Lei, Yan Wang, Diana Moeckel, Josbert M. Metselaar, Gert Storm, Wim E. Hennink, Fabian Kiessling, Hongbo Wei, Twan Lammers, Yang Shi, Bo Wei
Summary: Electron-stabilized polymeric micelles loaded with docetaxel showed high efficiency in enhancing chemotherapy responses in advanced-stage GI cancer mouse models, achieving complete cures and tumor regression in both CDX and PDX models. Moreover, the micellar docetaxel modulated the tumor immune microenvironment and was well-tolerated toxicologically, indicating significant potential for the treatment of advanced-stage GI cancers.
Article
Multidisciplinary Sciences
Tingzhen Li, Jianglong Huang, Purun Lei, Xiaofeng Yang, Zehong Chen, Peng Chen, Jiancheng Zhai, Xuefeng Guo, Hongbo Wei
Summary: This study aimed to identify the risk factors and develop a prediction model for anastomotic leakage in rectal cancer patients. The results showed that preoperative bowel obstruction and early first defecation after surgery were independent risk factors. The nomogram prediction model had good predictive ability, which could guide treatment and surgical decision-making.
Article
Orthopedics
Jingwen Liao, Zhou Qi, Biying Chen, Purun Lei
Summary: This retrospective analysis found that early ambulation within 3 days after TLIF surgery can significantly reduce length of hospital stay, total expenses, and incidence of postoperative complications.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Correction
Medicine, General & Internal
Jianpei Liu, Tufeng Chen, Purun Lei, Xiao Tang, Pinjie Huang
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Oncology
Guiru Jia, Purun Lei, Yanru Zhang, Zongheng Zheng, Jiafeng Fang, Xiaofeng Yang, Hongbo Wei, Tufeng Chen
Summary: The study aimed to explore reasonable lymph node classification strategies for left-sided colon cancer patients. Based on the analysis of a large database, the researchers proposed innovative revised nodal staging strategies and developed TrN and TLODDS classifications. These classifications demonstrated better discrimination, model-fitting, and net benefits than the existing TNM classification. The predictive performance of the TrN and TLODDS classifications was verified in validation and application sets.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Surgery
Purun Lei, Guiru Jia, Xiaofeng Yang, Ying Ruan, Bo Wei, Tufeng Chen
Summary: The study found that preoperative use of OA+MBP significantly reduces the incidence of SSIs in colorectal surgery, particularly in left-sided resections.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
XiaoFeng Yang, Purun Lei, Lijun Huang, Xiao Tang, Bo Wei, HongBo Wei
Summary: This study utilized computational methods to analyze transcriptional information of COAD and STAD, revealing a potential correlation between LRRC4C and the prognosis of colon and gastric cancer patients, as well as its association with gene enrichment in immune-related activities and metabolic pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Bo Wei, Xiao-Ming Zheng, Pu-Run Lei, Yong Huang, Zong-Heng Zheng, Tu-Feng Chen, Jiang-Long Huang, Jia-Feng Fang, Cheng-Hua Liang, Hong-Bo Wei
CHINESE MEDICAL JOURNAL
(2017)