Article
Rheumatology
Jean W. Liew, S. Reza Jafarzadeh, Maureen Dubreuil, Susan R. Heckbert, Stephen J. Mooney, Matthew A. Brown, Mariko L. Ishimori, John D. Reveille, Michael M. Ward, Michael H. Weisman, Lianne S. Gensler
Summary: This study found no significant association between TNFi use and incident hypertension in a longitudinal cohort of patients with ankylosing spondylitis.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Immunology
Yi-Fen Lai, Ting-Yi Lin, Wu-Chien Chien, Chien-An Sun, Chi-Hsiang Chung, Yi-Hao Chen, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that patients with AS who have uveitis are at a significantly higher risk of developing acute myocardial infarction (AMI) compared to those without uveitis. Regardless of gender or age group, patients with uveitis in the AS population have an increased risk for AMI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Reinder Raadsen, Romy Hansildaar, Lianne C. Pouw, Femke Hooijberg, Laura Boekel, Gerrit Jan Wolbink, Arno W. R. van Kuijk, Michael T. Nurmohamed
Summary: This study evaluates the cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA). The results show that the traditional cardiovascular risk factors are significantly elevated in these patients compared to healthy controls. However, after adjusting for traditional risk factors, the cardiovascular risk was not increased in these patients.
Article
Rheumatology
Xinzhe Feng, Chen Wang, Boyao Ji, Junjie Qiao, Yihong Xu, Shanbang Zhu, Zhou Ji, Bole Zhou, Wenwen Tong, Weidong Xu
Summary: This study used single-cell RNA sequencing to reveal the dynamics of cell subpopulations, gene expression, and intercellular interactions during the pathogenesis of ankylosing spondylitis, providing new insights into the cellular and molecular mechanisms of osteogenesis and potential therapeutic strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Zhihua Yin, Hui-Ying Low, Brian Shiian Chen, Kuo-Shu Huang, Yue Zhang, Yu-Hsun Wang, Zhizhong Ye, James Cheng-Chung Wei
Summary: This study found a higher risk of ankylosing spondylitis (AS) in patients with endometriosis, suggesting clinicians should be aware of the occurrence of AS in patients with endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Fataneh Tavasolian, Starlee Lively, Chiara Pastrello, Michael Tang, Melissa Lim, Addison Pacheco, Zoya Qaiyum, Enoch Yau, Zeynep Baskurt, Igor Jurisica, Mohit Kapoor, Robert D. Inman
Summary: Advances in genomics and proteomics have provided new insights into the biology of ankylosing spondylitis (AS), offering opportunities for improved diagnosis and management. Altered gene, microRNA, and protein expression have been implicated in immune dysregulation and inflammation in AS. This study demonstrates that exosomes from AS patients inhibit the proliferation of regulatory T cells, potentially contributing to the chronically activated T cells seen in this disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Chia-Jung Tsai, Yu-Chih Lin, Chung-Yu Chen, Chih-Hsing Hung, Yi-Ching Lin
Summary: This retrospective study analyzed the impact of biologics and non-biologics treatment on the development of hematologic malignancies in patients with AS, psoriasis, and PsA. The results showed that biologics significantly increased the risk of hematologic malignancies, specifically non-Hodgkin's lymphoma. Different treatment patterns, types of biologics, cumulative defined daily doses, comorbidities, and comedications did not have a significant effect on hematologic malignancy development.
Review
Rheumatology
Monica Schwartzman, Joerg Ermann, Kristine A. Kuhn, Sergio Schwartzman, Michael H. Weisman
Summary: This systematic literature review critically appraises study designs evaluating spondyloarthritis (SpA) phenotypes in patients with inflammatory bowel disease (IBD). The review finds that the characterization of SpA phenotypes in IBD patients remains incomplete and suggests the need for standardization of variables and definitions in order to advance clinical and research purposes.
Article
Immunology
Ta-hsin Tsung, Ke-Hao Huang, Wu-Chien Chien, Yi-Hao Chen, I-Chuan Yen, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis is a risk factor for stroke development in patients with AS, and both anterior uveitis and posterior segment involvement increase the risk of stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Juergen Braun, Joachim Sieper
Summary: The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex. It is associated with ankylosing spondylitis (AS) and plays a role in the immune system's defense against microbes. HLA B27 accounts for less than 30% of the genetic load and can be found in 60-90% of axSpA patients worldwide. Its prevalence in the population is linked to the prevalence of the disease.
Article
Rheumatology
Siwen Chen, Zihao Li, Dongying Chen, Haowen Cui, Jianru Wang, Zemin Li, Xiang Li, Zhaomin Zheng, Zhongping Zhan, Hui Liu
Summary: The aim of this study was to identify the role of Piezo1-mediated mechanotransduction in entheseal pathological new bone formation and explore the underlying molecular mechanism. It was found that Piezo1 was aberrantly upregulated in ligaments and entheseal tissues from patients with ankylosing spondylitis (AS) and animal models. Pharmacological and genetic inhibition of Piezo1 attenuated while its activation promoted pathological new bone formation. Mechanistically, activation of CaMKII signalling was found essential for Piezo1-mediated mechanotransduction. Additionally, Piezo1 was upregulated by AS-associated inflammatory cytokines.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Bora Nam, Sungsin Jo, So-Young Bang, Youngho Park, Ji Hui Shin, Ye-Soo Park, Seunghun Lee, Kyung Bin Joo, Tae-Hwan Kim
Summary: This study identified clinical and genetic factors associated with severe radiographic damage in patients with ankylosing spondylitis (AS). The results showed that baseline mSASSS, peripheral joint arthritis, uveitis, and smoking were significant clinical factors associated with radiographic damage. The RYR3 gene and the PI3K-Akt signaling pathway were also found to be associated with severe radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Clinical Neurology
Mahmud Omar, Niv Ben-Shabat, Avishai M. Tsur, Arnon D. Cohen, Abdulla Watad, Howard Amital, Kassem Sharif
Summary: A large retrospective, population-based, cross-sectional study shows that patients with AS have a higher prevalence of psychiatric disorders, particularly depression, and a lower prevalence of schizophrenia. Disease modifying drugs used for the management of AS are not predictors of psychiatric disorders in AS patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Rheumatology
Hao-Guang Li, Dan-Min Wang, Feng-Cai Shen, Shu-Xin Huang, Zhi-Duo Hou, Ling Lin, Zheng-Yu Xiao
Summary: Peripheral involvement is common in juvenile-onset non-radiographic axial spondyloarthritis, and risk factors associated with progression to juvenile-onset ankylosing spondylitis include inflammatory back pain, buttock pain, enthesitis, elevated baseline CRP levels, and sacroiliac joint-MRI positivity.
Review
Rheumatology
Man Li, Jhe-Yuan Hsu, Yong-Xin Xie, Yong-Lan Wu, James Cheng-Chung Wei
Summary: This article presents a case of a patient diagnosed with ankylosing spondylitis (AS) along with Kikuchi-Fujimoto disease (KFD), possibly triggered by infection or autoimmunity. Both AS and KFD involve a similar immune pathway, hence, the possibility of KFD should be considered when lymphadenopathy is observed, especially in patients with infection or underlying autoimmune diseases.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Psychology, Developmental
Iwen Chen, Jing-Yang Huang, Renin Chang, Yao-Min Hung, James Cheng-Chung Wei
Summary: This study found an association between parental obstructive sleep apnea (OSA) and offspring attention deficit hyperactivity disorder (ADHD), suggesting that the systemic inflammation and oxidative stress caused by OSA could be involved in the development of neurodevelopmental disorders.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Rheumatology
Tae-Hwan Kim, Mitsumasa Kishimoto, James Cheng-Chung Wei, Haeyoun Jeong, Akiyo Nozaki, Shigeto Kobayashi
Summary: Brodalumab demonstrated sustained efficacy and consistent safety in patients with axial spondyloarthritis over 68 weeks.
Article
Dermatology
Yu-Wen Chen, Amy Shen, Yu-Hsun Wang, James Cheng-Chung Wei, Chih-Jung Yeh
Summary: This nationwide retrospective cohort study revealed a risk association between herpes zoster and psoriasis, demonstrating an increased risk of psoriasis in patients diagnosed with herpes zoster.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fu-Shun Yen, James Cheng-Chung Wei, Ying-Hsiu Shih, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study compared the risks of cardiovascular morbidity and mortality between patients with and without microvascular diseases in type 2 diabetes (T2D), as well as between matched patients with microvascular diseases. The results showed that patients with microvascular diseases had a significantly higher risk of cardiovascular morbidity and mortality compared to those without microvascular diseases. Among the matched patients, diabetic retinopathy was significantly associated with stroke development, while diabetic neuropathy was significantly associated with stroke and heart failure development.
CARDIOVASCULAR DIABETOLOGY
(2023)
Editorial Material
Rheumatology
Cheng Hsien Hung, Yung-Heng Lee, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Chun-han Chang, Kevin Sheng-Kai Ma, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Wei-Yu Ma, Su-Boon Yong, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Psychiatry
Yi-Feng Lee, Meng-Che Wu, Kevin Sheng-Kai Ma, Jing-Yang Huang, James Cheng-Chung Wei
Summary: This nationwide population-based cohort study found that constipation in early childhood was significantly associated with an increased risk of autism spectrum disorder (ASD). Among constipated children, the severity of constipation, male gender, constipation during infancy, and atopic dermatitis were significantly associated with higher risks of ASD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Immunology
Jing-Xing Li, Yu-Hsun Wang, Henry Bair, Shu-Bai Hsu, Connie Chen, James Cheng-Chung Wei, Chun-Ju Lin
Summary: COVID-19 vaccines are associated with a higher risk of retinal vascular occlusion, according to a large multicenter study. The risk is increased immediately after vaccination and persists for 12 weeks. Both the BNT162b2 and mRNA-1273 vaccines are associated with this risk.
Letter
Rheumatology
Wei-Chiao Kao, Po-Cheng Shih, James Cheng-Chung Wei
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Medicine, General & Internal
Kuan-Jung Chen, Jing-Yang Huang, James Cheng-Chung Wei
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Peter Nash, Jan P. Dutz, Steve Peterson, Barkha P. Patel, Kiefer Eaton, May Shawi, Federico Zazzetti, James Cheng-Chung Wei
Summary: This study compares the relative effectiveness of targeted synthetic and biologic disease-modifying antirheumatic drugs on patient-reported outcomes through network meta-analysis. The results suggest that intravenous tumor necrosis factor (TNF) alpha inhibitors are generally more effective than other therapies for psoriatic arthritis patients. However, the differences between classes of therapies are small in terms of outcomes.
Article
Rheumatology
Pui-Ying Leong, Huang-Hsi Chen, Shuo-Yan Gau, Chia-Yin Chen, Yi-Chang Su, James Cheng-Chung Wei
Summary: Two Chinese medicine formulas, Wu-Ling San and Yin Chen Wu-Ling San, were found to be relatively safe for the short-term treatment of patients with hyperuricemia. However, there was no significant effect in lowering the serum urate levels.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Immunology
Pui-Ying Leong, Tsu-Man Chiu, James Cheng-Chung Wei, An-Ping Huo
Summary: This case report presents a rare occurrence of psoriasis combined with vitiligo in an Asian boy under the age of 6, and demonstrates that symptom improvement can be achieved with the use of methotrexate, indicating shared immune pathways between the two diseases.
FRONTIERS IN IMMUNOLOGY
(2023)