Article
Chemistry, Multidisciplinary
Shinnosuke Horiuchi, Keisuke Umakoshi
Summary: This review summarizes the progress in developing two types of unique luminescent supramolecular systems, including heteronuclear complexes involving heterometallic metal-metal interactions and host-guest systems consisting of mononuclear metal complexes and a hydrogen-bonded capsule.
Article
Nanoscience & Nanotechnology
Lijun Jiang, Jingfang Li, Diandong Xia, Min Gao, Weizuo Li, Ding-Yi Fu, Sicong Zhao, Guangming Li
Summary: A novel gelatin/glycerol film with high transparency, strength, and flexibility has been developed for luminescent security printing. The film exhibits reversible luminescent switching properties, can be rewritten and reused, and conveniently erased by heating. The addition of a QR code pattern and hybrid printing enhances the security of information.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Qing-Feng Li, Hongjun Xia, Erqing Li, Jin-Tao Wang, Zhenling Wang
Summary: This study successfully synthesized a hybrid material that can control luminescence through light stimuli, achieving the switching of luminescence of Eu3+ ions between ON and OFF states through repeated cycles of UV and visible light irradiation. This opens the possibility of developing lanthanide-based photoswitches for optical anti-counterfeiting and data storage.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Physical
Steffen Hardt, Stefanie Stapf, Dawit T. Filmon, James A. Birrell, Olaf Ruediger, Vincent Fourmond, Christophe Leger, Nicolas Plumere
Summary: The research describes a redox-active film for bidirectional and reversible hydrogen conversion, which can be used for electrocatalytic energy conversion. By serving as both the anode material and a highly energy efficient cathode material in a biofuel cell, the film demonstrates high performance. The understanding of reversibility through a kinetic model has simplified the design principles of highly efficient and stable bioelectrocatalytic films.
Article
Chemistry, Physical
Folkert de Vries, Edwin Otten
Summary: This article describes the redox-switching of a formazanate zinc catalyst in ring-opening polymerization of lactide. The catalytic activity can be modulated by reversible reduction/oxidation chemistry at a purely organic fragment, achieved by using a redox-active ligand bound to an inert metal ion (Zn2+). Kinetic and spectroscopic studies, along with mass spectrometry analysis of the catalysis mixture, provide insights into the nature of the active species and the initiation of lactide ring-opening polymerization. The mechanistic data highlights the crucial role of the redox-active ligand and offers an explanation for the formation of cyclic polymer.
Article
Chemistry, Inorganic & Nuclear
Bang-Heng Lyu, Ze-Yu Ruan, Wen Cui, Si-Guo Wu, Zhao-Ping Ni, Ming-Liang Tong
Summary: In this study, an inverse-Hofmann-type metal-organic framework (MOF) material [Fe-II(TPPE){Au-I(CN)(2)}]I.2H(2)O.7TCE with hysteretic spin crossover (SCO) behavior was reported. The redox-active unit [Au-I(CN)(2)](-) in the material can be oxidized by I-2 and Br-2 to form [Au-III(CN)(2)X-2](-) units via single-crystal to single-crystal transformation, and then reduced to [Au-I(CN)(2)](-) by l-ascorbic acid (AA). This study provides a platform for developing multi-responsive materials by regulating the SCO behavior through successive redox reactions.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Electrochemistry
Junyoung Park, Youngho Lee, Deokhee Yun, Doeun Kim, Gyungmin Hwang, Byeongjik Han, Yongbeom Kim, Jaehyun Jung, Joonhyeon Jeon
Summary: This paper presents a novel benzo[a]phenazin-5-ol methanesulfonate (BHPS) with sulfonic acid and hydroxyl functional groups, which exhibits stable and reversible redox reaction, high chemical stability, excellent conductivity, high redox potential, and good solubility in aqueous media. Experimental results demonstrate that BHPS has higher kinetic constant and solubility compared to benzo[a]phenazine-5-ol (HBP). BHPS/Fe(CN)6 flow-cell cycling shows high coulombic and energy efficiencies, as well as exceptional charge-and-discharge capacity retention ratios. BHPS provides a promising anodic organic species for highly efficient aqueous organic redox flow batteries (AORFBs) and can be further optimized through molecular engineering.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
Malee Sinchow, Takumi Konno, Apinpus Rujiwatra
Summary: This article describes the synthesis and characterization of lanthanide coordination polymers of 3,3???,5,5???-azobenzenetetracarboxylic acid sulfoxide and investigates their structural transformations and catalytic performance. The study reveals the rare case of reversible transformation in lanthanide coordination polymers and demonstrates the excellent catalytic performance of II.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Andreas Leng, Cornelius Weiss, Nina Strassner, Andreas Hirsch
Summary: An unprecedented compound class of functional organic hybrids consisting of a photoswitchable norbornadiene building block and a redoxactive chromophore, namely naphthalene diimide, were designed and synthesized. The capability of rylene chromophores to function as a redox active catalyst upon their photoexcitation was utilized to initiate the oxidative back-conversion of the in situ formed quadricyclane unit to its norbornadiene analogue. Controlled photoswitching between the two isomerical states of the hybrids was achieved through successive photoexcitation at two different wavelengths. The reaction rate was found to be dependent on the intramolecular distance of the two functional molecular building blocks as well as the concentration of the photoexcited sample. Quantum chemical investigations supported the experimental findings and interpretations.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Analytical
Minggang Tian, Jie Sun, Baoli Dong, Yanyan Ma, Weiying Lin
Summary: A new dual-emissive fluorescent probe has been developed for visualizing mitochondrial membrane potential changes, displaying reversible alterations and allowing for the observation of heterogeneous voltage distribution within single mitochondria. The innovative probe demonstrated potential for revealing cell damages induced by various reagents in biological research.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Danjun Liu, Yunxia Wang, Qiang Zhang, Ye Ming Qing, Yaorong Wang, Haitao Huang, Chi Wah Leung, Dangyuan Lei
Summary: This research presents a photoswitchable molecule-sandwiched metallic particle-on-film nanocavity that can achieve light-controlled linear and nonlinear optical tuning. It has the potential for developing miniaturized integrated optical circuits for ultrafast all-optical information processing and communication.
Review
Pharmacology & Pharmacy
Yang Li, Xiaoyue Zhang, Zhihan Wang, Bowen Li, Huili Zhu
Summary: Cancer treatment is hindered by resistance to conventional therapeutic strategies, and redox homeostasis manipulation can effectively overcome drug resistance. Reactive oxygen species (ROS) regulate multiple signaling pathways and cancer cells upregulate their antioxidant system to cope with elevated ROS levels during therapy, resulting in therapeutic resistance. This review highlights the interplay between redox modification, signaling pathways, and therapeutic resistance, including altered drug efflux, action targets and metabolism, enhanced DNA damage repair, maintained stemness, and reshaped tumor microenvironment. A comprehensive understanding of these interrelationships can improve treatment efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Dusan Kolarski, Carla Miro-Vinyals, Akiko Sugiyama, Ashutosh Srivastava, Daisuke Ono, Yoshiko Nagai, Mui Iida, Kenichiro Itami, Florence Tama, Wiktor Szymanski, Tsuyoshi Hirota, Ben L. Feringa
Summary: This study presents the development of a visible light-responsive inhibitor of casein kinase I, enabling precise and reversible control of cellular and tissue circadian rhythms. The inhibitor can switch between CKI isoforms and reveal the importance of CKI delta in period regulation, allowing for long-term regulation of CKI activity and reversible modulation of circadian rhythms through chronophotopharmacology.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zian Tang, Elena Chulanova, Maria Kuellmer, Andreas Winter, Julian Picker, Christof Neumann, Kristin Schreyer, Felix Herrmann-Westendorf, Andreas Arnlind, Benjamin Dietzek, Ulrich S. Schubert, Andrey Turchanin
Summary: This study presents a method for synthesizing photoactive metal-organic nanosheets with ultimate molecular thickness and the ability to reversibly complex lanthanide ions. These nanosheets can be prepared on a large scale, possess mechanical stability as free-standing sheets, and exhibit photoactivity inherited from the pristine terpyridine lanthanide complex. They offer a simple and robust way for preparing ultrathin nanosheets with tailored photoactive properties for applications in photocatalytic and energy conversion devices.
Article
Chemistry, Multidisciplinary
Hong-Wen Liang, Tian Jia, Zhen-Zhen Wang, Jia-Qi Wang, Da-Yong Hou, Lei Wang, Xingfa Gao, He-Lue Sun, Hao Wang
Summary: Electron donor-acceptor (D-A) structures are commonly used to develop fluorescent dyes with high quantum yields, but most D-A-type dyes experience a decrease in quantum yield with increasing solvent polarity. By modifying the structural engineering and introducing an intramolecular H-bond core unit with a rotational barrier, we have created a D-A-type fluorescent dye that maintains almost the same quantum yields across a range of solvent polarities.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Analytical
Mohamed Sharafeldin, Felix Fleschhut, Timothy James, Jason J. Davis
Summary: The emergence of protein biomarkers promises a revolution in healthcare, shifting the focus from disease management to earlier intervention. This study introduces a convenient method for protein tagging prior to target capture, allowing for easy quantification of biomarkers. When translated to an automated microfluidic platform, the method enables rapid and accurate quantification of markers, showing good correlation with standard immunoassays. The platform is simple, versatile, highly sensitive, and does not require secondary labeling/binding or amplification.
ANALYTICAL CHEMISTRY
(2022)
Article
Mathematics, Applied
E. Guerrero Fernandez, M. J. Castro Diaz, M. Dumbser, T. Morales de Luna
Summary: In this paper, a novel numerical discretization method is proposed for simulating a variable pressure multilayer shallow water model. The method is capable of simulating density driven gravity currents in a shallow water framework and maintains high accuracy even in the presence of strong gradients or discontinuities.
JOURNAL OF SCIENTIFIC COMPUTING
(2022)
Review
Nanoscience & Nanotechnology
Cheng Jiang, Ying Fu, Guozhen Liu, Bowen Shu, Jason Davis, George K. Tofaris
Summary: Extracellular vesicles (EVs) play a crucial role in molecular trafficking, intercellular transport, and protein egress. They can be detected in bodily fluids and offer opportunities for biomarker discovery. Multiplexing platforms can achieve breakthroughs in analytical power, throughput, and consistency.
NANO-MICRO LETTERS
(2022)
Article
Materials Science, Biomaterials
Connor M. Ellis, Juan Pellico, Liam A. J. Young, Jack Miller, Jason J. Davis
Summary: By adjusting the Dy3+ loading density within a mesoporous silica architecture, the dominant Curie effect can be effectively tuned to optimize T-2 contrast at high magnetic fields up to 11.7 T, enhancing image sensitivity in MRI scans.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Mohamed Sharafeldin, Jason J. Davis
Summary: The development of diagnostic devices relies on the immobilization of biomolecules to generate quantifiable signals. The selectivity and sensitivity of biosensors depend on the interfacial properties, which can be analyzed using characterization techniques.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Connor M. Ellis, Daohe Yuan, Ferenc E. Mozes, Jack J. Miller, Jason J. Davis
Summary: Paramagnetically-doped polymer micelles with ionizable poly(acrylic acid) (PAA) block enable high-contrast MR imaging at clinically relevant field strengths with strong pH sensitivity. The reversible switch in polymer strand charge directly affects the local rigidity and rotational correlation time characteristics of the integrated Gd-chelate, resulting in a 50% amplitude switch in positive contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Daisy Marshall, Joshua Lehr
Summary: The early detection of anti-asparaginase biomarker is important for timely modification of asparaginase chemotherapy and avoiding complications. A novel electrochemical biosensing interface was prepared for rapid detection of anti-asparaginase in the picomolar range. The coimmobilization of ferrocene and asparaginase facilitated transduction through attenuation of the surface-bound ferrocene redox couple, with a limit of detection of 0.8 pM.
Article
Chemistry, Multidisciplinary
Antoine L. D. Wallabregue, Hannah Bolland, Stephen Faulkner, Ester M. Hammond, Stuart J. Conway
Summary: Hypoxia, which occurs in various biological contexts, has a negative impact on the survival of biological systems such as plants, bacterial biofilms, and tumors. Chemical probes that can study biological hypoxia help to improve the understanding and treatment of diseases related to low oxygen levels. This study presents a range of indolequinone-based bioreductive fluorescent probes that can image different levels of hypoxia in cellular cultures, providing a convenient alternative to antibody-based imaging approaches.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Carlson Alexander, James A. Thom, Alan M. Kenwright, Kirsten E. Christensen, Thomas Just Sorensen, Stephen Faulkner
Summary: In this study, pre-organised binuclear kinetically inert lanthanide complexes, bridged by flexible -(CH2)(2)- and -(CH2)(3)- spacers, were shown to bind chloride with apparent association constants of up to 10(5) M-1 in water and in buffered systems. Hydroxide bridging was observed in these complexes at basic pH, but was overcome by chloride. These lanthanide complexes show promise towards chloride recognition in biology and beyond, opening up a new area of anion coordination chemistry for exploration.
Article
Chemistry, Analytical
Mohamed Sharafeldin, Shijun Yan, Cheng Jiang, George K. Tofaris, Jason J. Davis
Summary: We present a scalable, fast, and low-cost method for extracting cargo proteins from exosome subpopulations using an alternating (AC) magnetic field to facilitate the mixing of antibody-coated magnetic beads (MBs) with serum samples. By applying this method, we were able to achieve high capture efficiencies of >70% from <50 μL of neat serum in just 30 minutes. This approach, when combined with array-based assaying and a standard duplex electrochemical sandwich ELISA, enabled the detection of sub pg/mL levels of α-synuclein content with excellent precision and a sample-to-answer time of approximately 75 minutes. The high performance and semi-automation of this method hold promise for low-cost Parkinson's disease diagnostics and exosomal biomarker analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shaoyu Kang, Mohamed Sharafeldin, Sophie C. Patrick, Xuanxiao Chen, Jason J. Davis
Summary: We present a simple method for quantifying target proteins by monitoring the redox capacitance of a conductive polymer interface. This method allows real-time analysis of both association and dissociation regimes and can detect target proteins at picomolar levels within 15 seconds. This proof-of-principle methodology is expected to be widely applicable in quantifying other clinically relevant targets.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Krzysztof M. Bak, Sophie C. Patrick, Xiaoxiong Li, Paul D. Beer, Jason J. Davis
Summary: Mimicking Nature's polymeric protein architectures, designing hosts with binding cavities screened from bulk solvent is a promising approach to achieving anion recognition in competitive media. The authors present a synthetically tractable approach by directly incorporating potent supramolecular anion-receptive motifs into a polymeric scaffold. The polymeric hosts consistently outperform their monomeric analogues, with large halide binding enhancements observed in aqueous-organic solvent mixtures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Daohe Yuan, Connor M. Ellis, Ferenc E. Mozes, Jason J. Davis
Summary: High T-1 MRI switches can be obtained using pH-responsive polymer-coated paramagnetic mesoporous silica nanoparticles. The strong peripheral hydration capping at the mesopores enhances water mobility, leading to greatly enhanced outer sphere contributions to contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Yi Wang, Jack Howley, Erica N. N. Faria, Chen Huang, Sadie Carter-Searjeant, Simon Fairclough, Angus Kirkland, Jason J. J. Davis, Falak Naz, Muhammad Tariq Sajjad, Jose M. M. Goicoechea, Mark Green
Summary: We present a new synthetic method to prepare high-quality InP-based quantum dots (QDs) with tuneable emission, by using a solid, air- and moisture-tolerant primary phosphine as a group-V precursor. This method offers a significantly simpler synthetic pathway compared to the current state-of-the-art precursors used in phosphide quantum dot synthesis, which are volatile, dangerous, and sensitive to air, such as P(Si(CH3)(3))(3).
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Sharafeldin, Robert Hein, Jason J. Davis
Summary: We present a novel electrochemical protein quantitation method that involves shotgun biotin tagging of proteins before interfacial immunocapture and polymeric enzyme tagging. The highly amplified faradaic signals produced by a novel ferrocene-tyramine adduct allow for the detection of protein markers at attomolar levels and across a dynamic range of 5 orders of magnitude. This work supports the ultrasensitive detection of protein markers in a single antibody immunoassay format.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
