Article
Primary Health Care
Eric M. Matheson, Scott W. Bragg, Russell S. Blackwelder
Summary: Diabetes-related foot infections occur in 40% of diabetes-related foot ulcers, leading to significant morbidity. Evaluation for foot infection or osteomyelitis should consider patient risk factors and indicators of infection. Treatment should cover common pathogens, reflect local resistance patterns, and consider the severity of infection.
AMERICAN FAMILY PHYSICIAN
(2021)
Article
Immunology
Eric Senneville, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Edgar J. G. Peters
Summary: The International Working Group on the Diabetic Foot has published evidence-based guidelines on the management and prevention of diabetes-related foot diseases since 1999. This updated guideline uses the GRADE framework and provides recommendations for healthcare professionals involved in diabetes-related foot care. The recommendations cover various aspects of foot infections in diabetes patients, including diagnosis, treatment, and adjunctive therapies. The guideline aims to improve patient care, reduce amputations, and lessen the burden of diabetes-related foot disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Peter A. Lazzarini, Anita Raspovic, Jenny Prentice, Robert J. Commons, Robert A. Fitridge, James Charles, Jane Cheney, Nytasha Purcell, Stephen M. Twigg
Summary: This article summarizes the most relevant recommendations from six new guidelines for the general medical audience regarding diabetes-related foot disease. It covers prevention, classification, peripheral artery disease, infection, offloading, and wound healing.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Critical Care Medicine
Evans R. Fernandez Perez, William D. Travis, David A. Lynch, Kevin K. Brown, Kerri A. Johannson, Moises Selman, Jay H. Ryu, Athol U. Wells, Yuh-Chin Tony Huang, Carlos A. C. Pereira, Mary-Beth Scholand, Ana Villar, Naohiko Inase, Richard B. Evans, Stephen A. Mette, Lindsy Frazer-Green
Summary: The article summarizes evidence-based and consensus-derived guidance for clinicians to improve individual diagnostic decision-making for hypersensitivity pneumonitis (HP) and emphasizes the use of a multidisciplinary assessment approach in HP diagnosis. All evidence was of very low quality, indicating the need for further research on the performance and generalizability of diagnostic tools.
Article
Endocrinology & Metabolism
Emma J. Hamilton, Wendy A. Davis, Ranita Siru, Mendel Baba, Paul E. Norman, Timothy M. E. Davis
Summary: The incidence of DFU hospitalizations in patients with type 2 diabetes has increased between different age groups, especially in younger participants. Factors such as PSN, peripheral arterial disease, and suboptimal glycemic control at baseline were identified as independent predictors of incident hospitalization for/with DFU.
Review
Endocrinology & Metabolism
Edgar J. G. Peters, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Eric Senneville
Summary: The optimal approaches to managing diabetic foot infections are still challenging, as existing studies on different treatment strategies generally produce comparable results and lack high-quality data. Recent research shows that treatment methods yield similar results for skin and soft tissue infections as well as osteomyelitis in patients with diabetes, with a few exceptions. Antibiotic therapy can be shortened to 10 days post-surgical debridement for moderate or severe infections, while for osteomyelitis, the treatment duration can be reduced to 3 weeks post-surgical debridement. There is insufficient high-quality evidence for the effectiveness of various adjunctive therapies. Further well-designed trials are needed to support treatment recommendations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Surgery
Longhai Jin, Rong Xian Chia, Wendell Neilson, David Hardman, Gert Frahm-Jensen, Alister Jones
Summary: Our study evaluated the role of proximal bone microbiology and histopathology in the diagnosis and prediction of residual infection and revision operation. The results showed that histopathology was more reliable, while microbiology was valuable for guiding antibiotic selection.
ANZ JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Eric Senneville, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Edgar J. G. Peters
Summary: The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the management and prevention of diabetes-related foot diseases since 1999. This guideline is an update of the 2019 IWGDF guideline on the diagnosis and management of foot infections in persons with diabetes mellitus, developed using the GRADE framework. The recommendations cover various aspects of diagnosing and treating foot infections in diabetic patients, aimed at improving patient care, reducing amputations, and alleviating the burden of diabetes-related foot disease.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Medicine, General & Internal
Ranita Siru, Melanie S. Burkhardt, Wendy A. Davis, Jonathan Hiew, Laurens Manning, Jens Carsten Ritter, Paul E. Norman, Ashley Makepeace, Peter Gerry Fegan, David G. Bruce, Timothy M. E. Davis, Emma J. Hamilton
Summary: The study found that there was no significant difference in cognitive impairment between patients with type 2 diabetes and foot ulcers compared to patients without this condition, whether they were from hospital-based clinics or community settings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Matthew Malone, Michael Radzieta, Timothy J. Peters, Hugh G. Dickson, Saskia Schwarzer, Slade O. Jensen, Lawrence A. Lavery
Summary: This study aimed to differentiate between the host-microbe metatranscriptome in DRFUs with localized chronic infection or acute clinical infection using dual-RNA seq. The results showed upregulated differentially expressed genes in acute infections involved in inflammatory responses and T-cell signaling, while chronic infections upregulated genes related to cellular homeostasis. Microbial metatranscriptome analysis revealed toxins, motility, and energy metabolism genes enriched in acutely infected DRFUs, indicating greater pathogenicity and mechanisms in these infections.
Article
Immunology
William M. Geisler, Jane S. Hocking, Toni Darville, Byron E. Batteiger, Robert C. Brunham
Summary: This paper summarizes the key questions, evidence, and recommendations for the diagnosis and management of uncomplicated Chlamydia trachomatis (CT) infections in adolescents and adults that were reviewed and discussed for consideration in developing the 2021 Centers for Disease Control and Prevention (CDC) sexually transmitted infections treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Katie Rubitschung, Amber Sherwood, Andrew P. Crisologo, Kavita Bhavan, Robert W. Haley, Dane K. Wukich, Laila Castellino, Helena Hwang, Javier La Fontaine, Avneesh Chhabra, Lawrence Lavery, Orhan K. Oz
Summary: Diabetic foot infection is a major global cause of non-traumatic lower limb amputations, with increasing prevalence of diabetes mellitus and its complications. Improved clinical assessment and treatment are needed to address the growing pervasiveness and financial implications of DFI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Moin Uddin Ahmed, Wadad Kathy Tannous, Kingsley Emwinyore Agho, Frances Henshaw, Deborah Turner, David Simmons
Summary: The study estimated the disease burden of diabetes-related foot disease in Australia, finding that DALY was mainly attributed to lower limb amputations in males aged 65 and older, causing a significant burden on society and the healthcare system.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Endocrinology & Metabolism
Jianglin Zhang, Yue Qiu, Li Peng, Qiuhong Zhou, Zheng Wang, Min Qi
Summary: This article reviewed the current applications of deep learning in early detection of diabetes-related foot ulcers (DFU). Different algorithms were found to have different advantages in classification, object detection, and semantic segmentation tasks related to DFU images, achieving high accuracy in DFU identification.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jenny Riley, Christina Antza, Punith Kempegowda, Anuradhaa Subramanian, Joht Singh Chandan, Krishna Gokhale, Neil Thomas, Christopher Sainsbury, Abd A. Tahrani, Krishnarajah Nirantharakumar
Summary: Social deprivation is an independent risk factor for the development of DFD, PN, FU, PVD, LLA, and gangrene in newly diagnosed patients with type 2 diabetes. Strategies targeting patients in socially deprived areas are needed to reduce health inequalities considering the high individual and economic burdens of DFD.
