Article
Neurosciences
Carmen Munoz-Ballester, Dzenis Mahmutovic, Yusuf Rafiqzad, Alia Korot, Stefanie Robel
Summary: This study using a mouse model of mTBI found that exposure of neurons to blood-borne factors causes a rapid and sustained loss of neuronal proteins and changes in spine morphology, without neurodegeneration, which may be relevant to many neuropathologies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Rydzik, Tadeusz Ambrozy, Tomasz Palka, Wojciech Wasacz, Michal Spieszny, Jacek Perlinski, Pawel Krol, Marta Kopanska
Summary: The aim of this study was to develop a brainwave model using quantitative electroencephalography to assess the brain function of competitive K1 kickboxers. The results showed that the level of brain activity significantly differentiated the kickboxers from the control group in selected measurement areas, particularly in the frontal lobe where the activity of Delta waves was significantly higher than normal values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jason D. Vadhan, Robert C. Speth
Summary: This review discusses how activation of the brain RAS following TBI contributes to permanent brain damage, and how drugs that counteract activation of the AT(1)R can potentially ameliorate TBI-induced brain damage.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Neurosciences
Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is a leading cause of global disability, but predicting patient outcomes is challenging due to the heterogeneous nature of TBI in terms of injury severity and other factors. Neuroimaging research has been limited by small sample sizes, and the development of reliable biomarkers for mild TBI or repeated subconcussive impacts has been slow.
HUMAN BRAIN MAPPING
(2022)
Article
Orthopedics
Amelie Tremblay, Kathryn J. Schneider, Keith Owen Yeates, Geoff Schneider, Pierre Fremont
Summary: A comparative analysis was conducted on the SCAT5 and emergency room rules, showing that the SCAT5 has high sensitivity in identifying severe head and brain injuries, but there is still room for improvement.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2023)
Article
Clinical Neurology
Alexi Gosset, Hayley Wagman, Dan Pavel, Philip Frank Cohen, Robert Tarzwell, Simon de Bruin, Yin Hui Siow, Leonard Numerow, John Uszler, John F. Rossiter-Thornton, Mary McLean, Muriel van Lierop, Zohar Waisman, Stephen Brown, Behzad Mansouri, Vincenzo Santo Basile, Navjot Chaudhary, Manu Mehdiratta
Summary: A retrospective case review of 30 outpatients with mild traumatic brain injury (mTBI) found cerebral perfusion abnormalities demonstrated by SPECT, which were mostly undetectable by conventional imaging (CT/MRI). These perfusion changes were primarily localized in the cerebral cortex, basal ganglia, and cingulate cortex, and correlated with the patients' symptoms and examination findings.
FRONTIERS IN NEUROLOGY
(2022)
Article
Engineering, Biomedical
Jiawei Yin, A. Agung Julius, John T. Wen, John P. Hanifin, Benjamin Warfield, George C. Brainard
Summary: This paper introduces a method for estimating sleep/wake state based on actigraphy data, as well as a method for estimating circadian phase shift using an adaptive notch filter algorithm. The study also explores the relationship between concussion detection and sleep-related features.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Medicine, General & Internal
Diego Rivera, Sven Greving, Juan Carlos Arango-Lasprilla, Nicole von Steinbuechel, Marina Zeldovich
Summary: This study analyzed the long-term changes in RPQ symptoms from three to twelve months after TBI and identified factors related to these symptoms. The results showed that the three-factor structure of RPQ remains stable within one year after TBI. Sex, injury cause, and prior psychiatric problems were found to be related to both the factor structure and total score of RPQ.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Jessica-Dominique Lecques, Brynna J. K. Kerr, Lyn M. Hillyer, Jing X. Kang, Lindsay E. Robinson, W. L. David
Summary: This study demonstrates the protective effect of n-3 PUFA against mild brain injury, using a weight drop injury model on fat-1 mice and WT counterparts. The fat-1 mice showed significantly lower neurological severity scores and faster neurological restoration compared to WT mice post-injury.
Article
Clinical Neurology
Nusratnaaz Shaikh, Alice Theadom, Richard Siegert, Natalie Hardaker, Doug King, Patria Hume
Summary: The psychometric properties of the Brain Injury Screening Tool (BIST) symptom scale were evaluated in a sample of people with a mild Traumatic Brain Injury (mTBI) through Rasch analysis, resulting in an interval level measurement score for potential clinical use. The 15-item symptom scale of the BIST tool was found to be a psychometrically sound measure of symptom burden following mTBI, supporting the use of both total and sub scale scores for clinical use.
Article
Critical Care Medicine
Stephanie D. Agtarap, Laura Campbell-Sills, Sonia Jain, Xiaoying Sun, Sureyya Dikmen, Harvey Levin, Michael A. McCrea, Pratik Mukherjee, Lindsay D. Nelson, Nancy Temkin, Esther L. Yuh, Joseph T. Giacino, Geoffrey T. Manley, Murray B. Stein
Summary: The study identified emotional post-TBI symptoms, anhedonia, and pain interference as important predictors of lower life satisfaction following mild TBI. Insomnia and negative affect also predicted lower life satisfaction at specific time points. Tailoring evidence-based treatments for affective symptoms, pain, and insomnia may be beneficial in improving life satisfaction after mTBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
John Burke, James Gugger, Kan Ding, Jennifer A. Kim, Brandon Foreman, John K. Yue, Ava M. Puccio, Esther L. Yuh, Xiaoying Sun, Miri Rabinowitz, Mary J. Vassar, Sabrina R. Taylor, Ethan A. Winkler, Hansen Deng, Michael McCrea, Murray B. Stein, Claudia S. Robertson, Harvey S. Levin, Sureyya Dikmen, Nancy R. Temkin, Jason Barber, Joseph T. Giacino, Pratik Mukherjee, Kevin K. W. Wang, David O. Okonkwo, Amy J. Markowitz, Sonia Jain, Daniel Lowenstein, Geoffrey T. Manley, Ramon Diaz-Arrastia
Summary: This study revealed that the incidence of self-reported PTE after TBI was 2.8% and was independently associated with unfavorable outcomes, emphasizing the need for effective antiepileptogenic therapies after TBI.
Article
Medicine, General & Internal
Marjolein van der Vlegel, Suzanne Polinder, Ana Mikolic, Rana Kaplan, Nicole von Steinbuechel, Anne Marie Plass, Marina Zeldovich, Dominique van Praag, Fabian Bockhop, Katrin Cunitz, Isabelle Mueller, Juanita A. Haagsma
Summary: Research has shown that patients with mild traumatic brain injury (mTBI) are at risk for post-concussion (PC) symptoms, with 26.1% experiencing them, and post-traumatic stress disorder (PTSD) symptoms, with 9.8% experiencing them, with the majority experiencing both PC and PTSD symptoms. Patients with PC and/or PTSD symptoms reported lower health-related quality of life (HRQoL), higher rates of rehabilitation, and lower return to work rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Matthew J. Lennon, Helen Brooker, Byron Creese, Tony Thayanandan, Grant Rigney, Dag Aarsland, Adam Hampshire, Clive Ballard, Anne Corbett, Vanessa Raymont
Summary: Traumatic brain injury (TBI) causes cognitive impairment, and the most sensitive cognitive domains affected are attention and executive function, with double the effect compared to processing speed and working memory.
JOURNAL OF NEUROTRAUMA
(2023)