4.5 Review

TLR4 polymorphism and periodontitis susceptibility: A meta-analysis

Journal

MEDICINE
Volume 95, Issue 36, Pages -

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000004845

Keywords

meta-analysis; periodontal disease; periodontitis; polymorphism; TLR4

Funding

  1. NSFC (Natural Science Foundation of China) [81560186]
  2. Program for Science and Technology Innovative Talents Team of Guizhou Province [Qian Ke He Talents Team[2013]4026]
  3. Key Subjects Construction Program for High Institutions in Guizhou Province [SZXK-201207-04]
  4. Construction Program for Key Characteristic Laboratory in High Institutions of Guizhou Province [Qian Jiao He KY[2013]109]
  5. Social Development Projects of Guizhou Province [Qian Ke He SYLKZ[2013]3043]

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Background:Many primary and secondary studies reported the association between Toll-like receptor 4 (TLR4) polymorphism and periodontitis susceptibility, which mainly focused on TLR4-299A>G or TLR4-399C>T of Caucasian, however, these studies had different conclusions. The aim of this study was to reassess relative studies about TLR4 polymorphism and periodontitis susceptibility, and update meta-analysis.Methods:We searched the electronic database including CNKI (Chinese National Knowledge Infrastructure), PubMed, Embase, and hand searched relative studies until January 4, 2016. Two authors selected studies according to inclusion and exclusion criteria, assessed studies using Newcastle-Ottawa Scale case control study (NOS), and calculated the combined effect size using STATA software, version 12.0.Results:This meta-analysis included 18 studies, containing 2453 healthy participants and 2987 patients with chronic periodontitis (CP) and 462 patients with aggressive periodontitis (AP). There was a significance between TLR4C>G (rs7873784) allele and CP in Asian, and its recessive model was also significant (for C vs G: odds ratio [OR] = 0.72, 95% confidence interval [CI] = 0.54-0.95, I-2 = 0%; for CC+CG vs GG: OR = 0.66, 95% CI = 0.49-0.89, I-2 = 0%). However, we did not detect any significant relevance between other TLR4 polymorphism and periodontitis susceptibility in overall and subgroup analyses. The sensitive analysis showed that dropping any single studies did not affect the pooled-analysis results. Publication bias was not detected.Conclusions:The meta-analysis found association between TLR4C>G (rs7873784) allele and CP in Asian and it may passed on to offsprings in the form of recessiveness. However, further studies about the association between TLR4C>G (rs7873784) and CP is warranted to confirm.

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