Targeting the HIV Reservoir: Chimeric Antigen Receptor Therapy for HIV Cure

CAR immune cells: design principles, resistance and the next generation

(2023) Louai Labanieh et al.   NATURE

Combination anti-HIV antibodies provide sustained virological suppression

(2022) Michael C. Sneller et al.   NATURE

Evolving Strategies to Eliminate the CD4 T Cells HIV Viral Reservoir via CAR T Cell Immunotherapy

(2022) Jarrod York et al.   Frontiers in Immunology

Ciltacabtagene Autoleucel, an Anti–B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Follow-Up

(2022) Thomas Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Advances in HIV-1-specific chimeric antigen receptor cells to target the HIV-1 reservoir

(2022) Madhu C. Choudhary et al.   Journal of Virus Eradication

HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

(2022) Matthew T. Ollerton et al.   Frontiers in Immunology

In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells

(2022) Kim Anthony-Gonda et al.   JCI Insight

Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques

(2021) Isaac M. Barber-Axthelm et al.   JCI Insight

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

(2021) Nikhil C. Munshi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T-cell therapy for HIV cure

(2021) Oscar Alfageme-Abello et al.   Current Opinion in HIV and AIDS

Robust CAR-T memory formation and function via hematopoietic stem cell delivery

(2021) Anjie Zhen et al.   PLoS Pathogens

KTE-X19 for relapsed or refractory adult B-cell acute lymphoblastic leukaemia: phase 2 results of the single-arm, open-label, multicentre ZUMA-3 study

(2021) Bijal D Shah et al.   LANCET

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

(2021) Steven G. Deeks et al.   NATURE MEDICINE

Advances in the development of chimeric antigen receptor-T-cell therapy in B-cell acute lymphoblastic leukemia

(2020) Xian Zhang et al.   CHINESE MEDICAL JOURNAL

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

(2020) Lillian B. Cohn et al.   Cell Host & Microbe

HIV-Resistant and HIV-Specific CAR-Modified CD4+ T Cells Mitigate HIV Disease Progression and Confer CD4+ T Cell Help In Vivo

(2020) Colby R. Maldini et al.   MOLECULAR THERAPY

A Trispecific Anti-HIV Chimeric Antigen Receptor Containing the CCR5 N-Terminal Region

(2020) Agnes Hajduczki et al.   Frontiers in Cellular and Infection Microbiology

Advances in Developing CAR T-Cell Therapy for HIV Cure

(2020) Jinxin Qi et al.   Frontiers in Immunology

A Universal CAR-NK Cell Targeting Various Epitopes of HIV-1 gp160

(2020) Rebecca M. Lim et al.   ACS Chemical Biology

CAR T cells: Living HIV drugs

(2020) Haideh Namdari et al.   REVIEWS IN MEDICAL VIROLOGY

Engineering CAR T Cells to Target the HIV Reservoir

(2020) Wenli Mu et al.   Frontiers in Cellular and Infection Microbiology

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

(2020) Colby R. Maldini et al.   NATURE MEDICINE

Memory and CAR-NK cell-based novel approaches for HIV vaccination and eradication

(2019) Abdulbaset Mazarzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review

(2019) Giorgio Zenere et al.   DRUG DISCOVERY TODAY

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

The making and function of CAR cells

(2019) Maja Zabel et al.   IMMUNOLOGY LETTERS

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

(2019) Kim Anthony-Gonda et al.   Science Translational Medicine

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform

(2019) Eytan Herzig et al.   CELL

Development of CAR-T cells for long-term eradication and surveillance of HIV-1 reservoir

(2019) Bingfeng Liu et al.   Current Opinion in Virology

Efficacy and safety of chimeric antigen receptor-T cells in the treatment of B cell lymphoma

(2019) Xiao-Hong Zheng et al.   CHINESE MEDICAL JOURNAL

Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti–human immunodeficiency virus potency and breadth with minimal immunogenicity

(2018) Mustafa H. Ghanem et al.   CYTOTHERAPY

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering

(2017) Victor I. Ayala et al.   JOURNAL OF VIROLOGY

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

(2017) Anjie Zhen et al.   PLoS Pathogens

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

(2017) Rachel S. Leibman et al.   PLoS Pathogens

Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

(2017) Dongfang Liu et al.   Protein & Cell

Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller

(2017) Victoria E. Walker-Sperling et al.   EBioMedicine

HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies

(2016) Ayub Ali et al.   JOURNAL OF VIROLOGY

Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4 + T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

(2016) Bingfeng Liu et al.   JOURNAL OF VIROLOGY

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

(2015) Li Liu et al.   JOURNAL OF VIROLOGY

HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells

(2015) Anjie Zhen et al.   MOLECULAR THERAPY

Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility

(2015) Dara M. Strauss-Albee et al.   Science Translational Medicine

Advantages and applications of CAR-expressing natural killer cells

(2015) Wolfgang Glienke et al.   Frontiers in Pharmacology

Utilizing Chimeric Antigen Receptors to Direct Natural Killer Cell Activity

(2015) David L. Hermanson et al.   Frontiers in Immunology

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

(2013) C. A. Didigu et al.   BLOOD

Expression of Chimeric Receptor CD4ζ by Natural Killer Cells Derived from Human Pluripotent Stem Cells Improves In Vitro Activity but Does Not Enhance Suppression of HIV Infection In Vivo

(2013) Zhenya Ni et al.   STEM CELLS

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

(2012) Scott G. Kitchen et al.   PLoS Pathogens

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

(2011) R. J. Brentjens et al.   BLOOD

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction

(2010) Anne Nolting et al.   VIROLOGY

Elucidating the elite: mechanisms of control in HIV-1 infection

(2009) Karen A. O’Connell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES