Article
Oncology
Jia-Yi Wu, Ju-Xian Sun, Yan-Nan Bai, Xiao-Xiao Huang, Jun-Yi Wu, Yong-Gang Wei, Zhi-Bo Zhang, Jian-Yin Zhou, Yao-Dong Wang, Shu-Qun Cheng, Mao-Lin Yan
Summary: Anatomic resection (AR) is recommended for hepatocellular carcinoma (HCC) patients with bile duct tumor thrombus (BDTT), especially in patients with tumors smaller than 5 cm, as it leads to better recurrence-free survival and overall survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Qiao Ke, Zhiting Guo, Jian He, Zisen Lai, Fuli Xin, Yongyi Zeng, Lei Wang, Jingfeng Liu
Summary: The width of resection margin (RM) does not appear to have a significant impact on the prognosis of patients with solitary hepatocellular carcinoma (HCC) undergoing anatomical resection (AR). However, in certain selected patients, a wider RM may confer benefits.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Oncology
Yao Huang, Hengkai Chen, Yongyi Zeng, Zhiqiang Liu, Handong Ma, Jingfeng Liu
Summary: A machine learning prognostic model was developed to identify high-risk patients after surgical resection, with variable importance reviewed in different time intervals. Tumor characteristics contribute more to HCC relapse in 0 to 1 year, while HBV infection and smoking largely affect patients' outcome in 3 to 5 years.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lihong Liu, Yongjie Shui, Qianqian Yu, Yinglu Guo, Lili Zhang, Xiaofeng Zhou, Risheng Yu, Jianying Lou, Shumei Wei, Qichun Wei
Summary: Patients with narrow resection margin had higher recurrence rate and worse survival compared to those with wide resection margin. Adjuvant local treatment, such as radiotherapy, may benefit these patients. Postoperative SBRT for cases with positive margin showed low recurrence rate and no marginal recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jianwei Liu, Guokun Zhuang, Shilei Bai, Zhiliang Hu, Yong Xia, Caixia Lu, Jie Wang, Chunyan Wang, Liu Liu, Fengwei Li, Yeye Wu, Feng Shen, Kui Wang
Summary: This study investigated the impact of surgical margin and hepatic resection on prognosis for patients with hepatocellular carcinoma (HCC). The results showed that for patients with MVI-positive HCC, wide margins and anatomical resection were protective factors for prognosis, with wide margins being more important. In clinical practice, ensuring wide margins should be prioritized.
Article
Oncology
Che-Min Su, Chung-Ching Chou, Tsung-Han Yang, Yih-Jyh Lin
Summary: The study compared the prognosis after anatomic resection (AR) and non-anatomic resection (NAR) for single hepatocellular carcinoma (HCC) less than 2 cm in diameter and found comparable outcomes between the two groups. Wide surgical resection margin was found to impact recurrence-free survival in the NAR group, suggesting the importance of maintaining a margin width of >= 1 cm during NAR for better oncologic outcomes. Independent prognostic factors for prognosis included low preoperative platelet count and presence of satellite nodules.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Oncology
Jiang-Min Zhou, Chen-Yang Zhou, Xiao-Ping Chen, Zhi-Wei Zhang
Summary: In patients with tumors ranging from 2-5 cm, anatomic resection (AR) can effectively remove peritumoral microvascular invasion (MVI) by obtaining a wide surgical margin, reducing postoperative recurrence, and improving prognosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Article
Urology & Nephrology
Nicolas Vamour, Anis Gasmi, Xavier Leroy, Philippe Puech, Mohamed Koussa, Arnauld Villers, Jean-Christophe Fantoni, Nicolas Doumerc, Karim Bensalah, Jonathan Olivier, Zine-Eddine Khene
Summary: This study evaluated the impact of positive vascular margins (PVMs) following surgical resection of non-metastatic renal cell carcinoma (RCC) with inferior vena cava (IVC) tumor thrombus. Results indicated that PVMs were associated with a higher risk of local recurrence, but did not have a significant impact on systemic recurrence or overall mortality.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Liuhua Long, Bo Chen, Hongzhi Wang, Yuting Zhao, Fan Wu, Liming Wang, Weiqi Rong, Jianxiong Wu, Yexiong Li, Weihu Wang
Summary: This study evaluated the effects of postoperative radiotherapy (PORT) on prognosis and recurrence in patients with hepatocellular carcinoma (HCC) who underwent narrow-margin hepatectomy (NH). The results showed that the PORT group had significantly higher 5-year overall survival and disease-free survival rates compared to the non-PORT group, and the tumor recurrence rate was lower in the PORT group. Therefore, postoperative radiotherapy may have significant benefits in the treatment of HCC.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zeyong Li, Jialin Yu, Yehan Li, Ying Liu, Manjing Zhang, Hanfeng Yang, Yong Du
Summary: This study constructed preoperative models based on CT radiomics, radiologic and clinical features to predict recurrence-free survival (RFS) after liver resection (LR) of BCLC 0 to B stage hepatocellular carcinoma (HCC) and to classify the prognosis.
ACADEMIC RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jonggi Choi, Chanyoung Jo, Young-Suk Lim
Summary: This study compared HCC recurrence and survival in HBV-related HCC patients treated with TDF or ETV after surgical resection, finding that TDF therapy was associated with a significantly lower risk of HCC recurrence and better overall survival.
Article
Oncology
Andriy Trailin, Lenka Cervenkova, Filip Ambrozkiewicz, Esraa Ali, Phanindra Kasi, Richard Palek, Petr Hosek, Vladislav Treska, Ondrej Daum, Zbynek Tonar, Vaclav Liska, Kari Hemminki
Summary: This study found that the distribution and numbers of T- and B-lymphocytes in different regions of the resected tumor have different prognostic significance for time to recurrence and disease-free survival in patients with hepatocellular carcinoma (HCC). The density of nucleated lymphocyte profiles in specific regions predicted longer time to recurrence and disease-free survival, highlighting the overall heterogeneity of the tumor invasive margin and the importance of B-cells in predicting outcomes.
Article
Oncology
Yi-Min Gu, Yu-Shang Yang, Wei-Li Kong, Qi-Xin Shang, Han-Lu Zhang, Wen-Ping Wang, Yong Yuan, Guo-Wei Che, Long-Qi Chen
Summary: This study aimed to investigate the impact of circumferential resection margin (CRM) status on survival and recurrence in esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy. The results showed that a CRM greater than 1 mm had better overall survival, longer disease-free survival, and less recurrence compared to a CRM of 1 mm or less.
FRONTIERS IN ONCOLOGY
(2022)