Radioprotective Agents: Strategies and Translational Advances

Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status

(2015) Holger Klammer et al.   CANCER LETTERS

Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): A review

(2015) Vijay K. Singh et al.   CYTOKINE

Patents for Toll-like receptor ligands as radiation countermeasures for acute radiation syndrome

(2015) Vijay K Singh et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Medical Countermeasures for Radiation Exposure and Related Injuries

(2015) Vijay K. Singh et al.   HEALTH PHYSICS

Melatonin as a treatment for gastrointestinal cancer: a review

(2015) Zhenlong Xin et al.   JOURNAL OF PINEAL RESEARCH

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

(2015) Xinwei Wang et al.   Scientific Reports

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis

(2015) Akinori Morita et al.   Oncotarget

Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection

(2014) Pei-Xin Tan et al.   Asian Pacific Journal of Cancer Prevention

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

(2014) Lakhan Kma   Asian Pacific Journal of Cancer Prevention

AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation

(2014) Akinori Morita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multifunctional Activity of a Small Tellurium Redox Immunomodulator Compound, AS101, on Dextran Sodium Sulfate-induced Murine Colitis

(2014) Gilad Halpert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation

(2014) Zoya Gluzman-Poltorak et al.   Journal of Hematology & Oncology

Immunobiology of Radiotherapy: New Paradigms

(2014) Mansoor M. Ahmed et al.   RADIATION RESEARCH

Radioprotection of targeted and bystander cells by methylproamine

(2014) Susanne Burdak-Rothkamm et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Can Melatonin Help Us in Radiation Oncology Treatments?

(2014) Ehsan Mihandoost et al.   Biomed Research International

Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence

(2014) Mikhail V Vasin   SpringerPlus

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

MnSOD in Oxidative Stress Response-Potential Regulation via Mitochondrial Protein Influx

(2013) Demet Candas et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll-like Receptor 5 Agonism Protects Mice from Radiation Pneumonitis and Pulmonary Fibrosis

(2013) Zhi-Dong Wang et al.   Asian Pacific Journal of Cancer Prevention

Synthesis, radioprotective activity and pharmacokinetics characteristic of a new stable nitronyl nitroxyl radical-NIT2011

(2013) Haibo Wang et al.   BIOCHIMIE

Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway

(2013) Mohammad Zahid Kamran et al.   BIOMEDICINE & PHARMACOTHERAPY

Radioprotectors - the Evergreen Topic

(2013) Vesna S. Kuntić et al.   CHEMISTRY & BIODIVERSITY

Radioprotective efficacy and toxicity of a new family of aminothiol analogs

(2013) Richard R. Copp et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice

(2013) Bing Wang et al.   JOURNAL OF RADIATION RESEARCH

Selenium biochemistry and its role for human health

(2013) Marco Roman et al.   Metallomics

Nanoparticle-mediated Gene Silencing Confers Radioprotection to Salivary Glands In Vivo

(2013) Szilvia Arany et al.   MOLECULAR THERAPY

Radioprotective role of clinical drug diclofenac sodium

(2013) Amit Alok et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist

(2013) L. G. Burdelya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cancer drug discovery by repurposing: teaching new tricks to old dogs

(2013) Subash C. Gupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe)

(2013) Raghavendra Haniadka et al.   Food & Function

Reduced Glutathione: A Radioprotector or a Modulator of DNA-Repair Activity?

(2013) Anupam Chatterjee   Nutrients

Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine

(2013) Xinyue Lu et al.   Cell and Bioscience

Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation

(2012) Fengxiang Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line

(2012) Mohammed Zahid Kamran et al.   BIOMEDICINE & PHARMACOTHERAPY

Radiation damage and radioprotectants: new concepts in the era of molecular medicine

(2012) M I Koukourakis   BRITISH JOURNAL OF RADIOLOGY

Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury

(2012) M. A. Kopp et al.   CELL AND TISSUE RESEARCH

Baicalein (5,6,7-trihydroxyflavone) reduces oxidative stress-induced DNA damage by upregulating the DNA repair system

(2012) Ki Cheon Kim et al.   CELL BIOLOGY AND TOXICOLOGY

Ferulic acid, a dietary phenolic acid, modulates radiation effects in Swiss albino mice

(2012) Janakiraman Shanthakumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Manganese superoxide dismutase regulation and cancer

(2012) Sanjit Kumar Dhar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Celebrating 25 years of NF-κB research

(2012) Sankar Ghosh et al.   IMMUNOLOGICAL REVIEWS

A New Orally Active, Aminothiol Radioprotector-Free of Nausea and Hypotension Side Effects at Its Highest Radioprotective Doses

(2012) Cheryl M. Soref et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Insulin-Like Growth Factor 1 Mitigates Hematopoietic Toxicity After Lethal Total Body Irradiation

(2012) Dunhua Zhou et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Randomized Trial of Pentoxifylline and Vitamin E vs Standard Follow-up After Breast Irradiation to Prevent Breast Fibrosis, Evaluated by Tissue Compliance Meter

(2012) Geraldine Jacobson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures

(2012) Szilvia Arany et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis

(2012) Marcy B. Grace et al.   JOURNAL OF RADIATION RESEARCH

Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice

(2012) S. P. Ghosh et al.   JOURNAL OF RADIATION RESEARCH

Prevention and Mitigation of Acute Radiation Syndrome in Mice by Synthetic Lipopeptide Agonists of Toll-Like Receptor 2 (TLR2)

(2012) Alexander N. Shakhov et al.   PLoS One

DMA, a Bisbenzimidazole, Offers Radioprotection by Promoting NFκB Transactivation through NIK/IKK in Human Glioma Cells

(2012) Navrinder Kaur et al.   PLoS One

Proton-Coupled Electron-Transfer Mechanism for the Radical Scavenging Activity of Cardiovascular Drug Dipyridamole

(2012) Abolfazl Barzegar   PLoS One

Identification of Druggable Targets for Radiation Mitigation Using a Small Interfering RNA Screening Assay

(2012) Crystal D. Zellefrow et al.   RADIATION RESEARCH

CBLB613: A TLR 2/6 Agonist, Natural Lipopeptide ofMycoplasma arginini, as a Novel Radiation Countermeasure

(2012) Vijay K. Singh et al.   RADIATION RESEARCH

ROS-Scavenger and Radioprotective Efficacy of the New PrC-210 Aminothiol

(2012) Daniel D. Peebles et al.   RADIATION RESEARCH

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Radioprotective effects of Zingiber officinale Roscoe (Ginger): past, present and future

(2012) Manjeshwar Shrinath Baliga et al.   Food & Function

Shifting the balance of mitochondrial apoptosis: therapeutic perspectives

(2012) Simone Fulda   Frontiers in Oncology

The Potential Dual Effects of Anesthetic Isoflurane on Hypoxia-Induced Caspase-3 Activation and Increases in β-Site Amyloid Precursor Protein-Cleaving Enzyme Levels

(2011) Chuxiong Pan et al.   ANESTHESIA AND ANALGESIA

Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents

(2011) G. Fritz et al.   BRITISH MEDICAL BULLETIN

Radiation-Induced Testicular Injury and Its Amelioration byTinospora cordifolia(An Indian Medicinal Plant) Extract

(2011) Priyanka Sharma et al.   Evidence-based Complementary and Alternative Medicine

A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector

(2011) Ryan M. Davis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toll-like Receptor 5 Agonist Protects Mice From Dermatitis and Oral Mucositis Caused by Local Radiation: Implications for Head-and-Neck Cancer Radiotherapy

(2011) Lyudmila G. Burdelya et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumor hypoxia is an important mechanism of radioresistance in hypofractionated radiotherapy and must be considered in the treatment planning process

(2011) David J. Carlson et al.   MEDICAL PHYSICS

Antiradical, Chelating and Antioxidant Activities of Hydroxamic Acids and Hydroxyureas

(2011) Marijana Zovko Končić et al.   MOLECULES

Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood

(2011) Alireza Shirazi et al.   Physica Medica-European Journal of Medical Physics

Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy

(2010) C. A. S. Franca et al.   ANNALS OF ONCOLOGY

Pharmacokinetic analysis of in vivo disposition of heparin–superoxide dismutase

(2010) J. Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Sodium Orthovanadate Inhibits p53-Mediated Apoptosis

(2010) A. Morita et al.   CANCER RESEARCH

Sphingosine-1-Phosphate Activates the AKT Pathway to Protect Small Intestines from Radiation-Induced Endothelial Apoptosis

(2010) S. Bonnaud et al.   CANCER RESEARCH

Management of Differentiated Thyroid Cancer with Rising Thyroglobulin and Negative Diagnostic Radioiodine Whole Body Scan

(2010) M. Chao   CLINICAL ONCOLOGY

Neurotoxins: Free Radical Mechanisms and Melatonin Protection

(2010) Russel J. Reiter et al.   Current Neuropharmacology

The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation

(2010) John S. Thompson et al.   FREE RADICAL RESEARCH

A New Class of Molecular Targeted Radioprotectors: GSK-3β Inhibitors

(2010) Dinesh K. Thotala et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radioprotective Effects of Aegle marmelos (L.) Correa (Bael): A Concise Review

(2010) Manjeshwar Shrinath Baliga et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Radioprotective potential of mint: A brief review

(2010) ManjeshwarS Baliga et al.   Journal of Cancer Research and Therapeutics

Radioprotection: smart games with death

(2010) Andrei V. Gudkov et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition

(2010) Søren M. Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs

(2010) Ajay Goel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

(2010) D. Citrin et al.   ONCOLOGIST

Dendro[C60]fullerene DF-1 provides radioprotection to radiosensitive mammalian cells

(2010) Corey A. Theriot et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

The use of ebselen for radioprotection in cultured cells and mice

(2009) Jean Kyoung Tak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo

(2009) Grigory V. Andrievsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo radioprotection studies of 3,3′-diselenodipropionic acid, a selenocystine derivative

(2009) Amit Kunwar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Poly(ADP-Ribose) Polymerase-1 and DNA-Dependent Protein Kinase Have Equivalent Roles in Double Strand Break Repair Following Ionizing Radiation

(2009) Jody Mitchell et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Selenium in Oncology: From Chemistry to Clinics

(2009) Oliver Micke et al.   MOLECULES

Thymol, a naturally occurring monocyclic dietary phenolic compound protects Chinese hamster lung fibroblasts from radiation-induced cytotoxicity

(2009) P.R. Archana et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Radiation Protection by a New Chemical Entity, Ex-Rad™: Efficacy and Mechanisms

(2009) Sanchita P. Ghosh et al.   RADIATION RESEARCH

High-Dose Selenium for the Mitigation of Radiation Injury: A Pilot Study in a Rat Model

(2009) Fritz Sieber et al.   RADIATION RESEARCH

γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism

(2009) Maaike Berbée et al.   RADIATION RESEARCH

Evaluation of the Radioprotective Effects of Propolis and Flavonoids in Gamma-Irradiated Mice: The Alkaline Comet Assay Study

(2008) Vesna Benković et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials

(2008) Jun-Jie Yin et al.   BIOMATERIALS

Mitigation of radiation-induced skin injury by AAV2-mediated MnSOD gene therapy

(2008) Shiqing Yan et al.   JOURNAL OF GENE MEDICINE

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

(2008) M. Toulany et al.   MOLECULAR CANCER THERAPEUTICS

The radioprotector Bowman–Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport

(2008) Klaus Dittmann et al.   RADIOTHERAPY AND ONCOLOGY

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE

Selenium: its role as antioxidant in human health

(2008) Ujang Tinggi   Environmental Health and Preventive Medicine

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats

(2007) Heba H. Mansour et al.   BIOCHEMICAL PHARMACOLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY