Article
Cell Biology
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy
Summary: Mitophagy plays a crucial role in maintaining cardiac homeostasis by selectively eliminating dysfunctional mitochondria. It is mainly regulated by the PINK1/parkin pathway and also by the FUNDC1, BNIP3, and BNIP3L/NIX pathways. Dysregulated mitophagy is associated with cardiac dysfunction, while moderate mitophagy has a cardioprotective effect.
Article
Multidisciplinary Sciences
Gal Yaniv, Arik Eisenkraft, Lilach Gavish, Linn Wagnert-Avraham, Dean Nachman, Jacob Megreli, Gil Shimon, Daniel Rimbrot, Ben Simon, Asaf Berman, Matan Cohen, David Kushnir, Ruth Shaylor, Baruch Batzofin, Shimon Firman, Amir Shlaifer, Michael Hartal, Yuval Heled, Elon Glassberg, Yitshak Kreiss, S. David Gertz
Summary: This study investigated the effects of limb remote ischemic preconditioning (RIPC) in a controlled hemorrhage model on survival rate and physiological status of pigs. The results showed that animals in the RIPC group had faster recovery of mean arterial pressure, higher heart rates, less decrease in bicarbonate, higher global oxygen delivery, and lower tissue oxygen extraction ratio after hemorrhage.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Eman Gouda, Fawzi Babiker
Summary: This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic in protecting the heart against ischemia/reperfusion injury. The results showed that GA significantly reduced infarct size and cardiac enzyme levels, and decreased pro-inflammatory cytokine levels.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Sebastian Roth, Carolin Torregroza, Katharina Feige, Benedikt Preckel, Markus W. Hollmann, Nina C. Weber, Ragnar Huhn
Summary: Pharmacological conditioning aims to protect the heart from myocardial I/R injury, but there remains a gap between basic research and clinical practice. This review covers new developments in experimental research and clinical evidence, highlighting the challenges of applying pharmacological conditioning in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yushi Wu, Haiqiong Liu, Xianbao Wang
Summary: Acute myocardial infarction requires timely reperfusion to reduce myocardial damage, but reperfusion may lead to myocardial ischemia/reperfusion injury. Pharmacological postconditioning is an effective and flexible strategy to reduce myocardial injury by administering medication before or during early reperfusion.
Article
Biochemistry & Molecular Biology
Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gomori, Istvan Adorjan Szabo, Gergely Agoston, Gabor Brenner, Peter Bencsik, Peter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Hypoxia upregulates PCSK9 in the heart, which affects myocyte function. Genetic deletion of PCSK9 or antagonism of circulating PCSK9 reduces reperfusion injury. A high-fat diet decreases survival rate during reperfusion, likely due to increased MMP9 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Janina Pape, Helena Kerp, Helmut R. Lieder, Daniela Geist, Georg Sebastian Hoenes, Lars C. Moeller, Petra Kleinbongard, Dagmar Fuehrer
Summary: Hypothyroidism and the lack of canonical TR alpha signaling have been shown to be cardioprotective in ischemia/reperfusion injury by reducing infarct size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Binghui Jin, Guangyao Li, Lin Zhou, Zhe Fan
Summary: This paper outlines the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Estefanie Osorio-Llanes, Wendy Villamizar-Villamizar, Maria Clara Ospino Guerra, Luis Antonio Diaz-Ariza, Sara Camila Castiblanco-Arroyave, Luz Medrano, Daniela Mengual, Ricardo Belon, Jairo Castellar-Lopez, Yanireth Sepulveda, Cesar Vasquez-Trincado, Aileen Y. Chang, Samir Bolivar, Evelyn Mendoza-Torres
Summary: The search for new drugs to effectively treat cardiovascular diseases is crucial due to their high mortality rate globally. Metformin, commonly used to control diabetes, has shown potential cardioprotective effects by regulating cellular energy metabolism and reducing oxidative stress. Clinical trials have revealed promising results, particularly in acute myocardial infarction cases. This review discusses the molecular and pharmacological mechanisms underlying the cardioprotective effects of metformin during myocardial ischemia-reperfusion injury.
Article
Biochemistry & Molecular Biology
Alice E. Zemljic-Harpf, Louise E. See Hoe, Jan M. Schilling, Juan P. Zuniga-Hertz, Alexander Nguyen, Yash J. Vaishnav, Gianna J. Belza, Boris P. Budiono, Piyush M. Patel, Brian P. Head, Wolfgang H. Dillmann, Sushil K. Mahata, Jason N. Peart, David M. Roth, John P. Headrick, Hemal H. Patel
Summary: The study demonstrates that morphine treatment can improve cardiac function and structure, enhance tolerance to ischemia-reperfusion injury, and potentially have translational value in diabetic patients.
Article
Biochemistry & Molecular Biology
Ji-Won Hwang, Jae-Hyun Park, Bong-Woo Park, Hyeok Kim, Jin-Ju Kim, Woo-Sup Sim, Natalia P. Mishchenko, Sergey A. Fedoreyev, Elena A. Vasileva, Kiwon Ban, Hun-Jun Park, Sang-Hong Baek
Summary: Histochrome (HC), with potent antioxidant and iron-chelating capacity, is shown to improve cardiac function and reduce cardiac fibrosis in myocardial I/R injury by decreasing intracellular and mitochondrial ROS levels, preventing ferroptotic cell death. Early intervention with HC before reperfusion is a promising therapeutic option for secondary cardioprotection in patients who undergo coronary reperfusion therapy.
Review
Biochemistry & Molecular Biology
Sergey Popov, Alexander Mukhomedzyanov, Nikita S. Voronkov, Ivan A. Derkachev, Alla A. Boshchenko, Feng Fu, Galina Z. Sufianova, Maria S. Khlestkina, Leonid N. Maslov
Summary: Ischemia/reperfusion leads to increased autophagic flux in the heart. Preconditioning stimulates autophagic flux by activating AMPK and PI3-kinase and inhibiting mTOR. The cardioprotective effect of postconditioning is associated with autophagy activation and increased activity of NO-synthase and AMPK. Oxidative stress stimulates autophagy, possibly through AMPK activation.
Article
Medicine, Research & Experimental
N. V. Naryzhnaya, A. S. Sementsov, L. N. Maslov, I. A. Derkachev
Summary: The role of NO synthase in the infarct-limiting effect of short-term (SNH) and chronic continuous normobaric hypoxia (CNH) was studied. It was found that non-selective NO synthase inhibitor L-NAME and inducible NO synthase inhibitor S-methylthiourea abolished the infarct-limiting effect of SNH and CNH. Nitric oxide donor diethylenetriamine increased cardiac tolerance to ischemia/reperfusion. Inducible NO synthase is believed to play an important role in the cardioprotective effect of normobaric hypoxia.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
S. V. Logvinov, A. V. Mukhomedzyanov, B. K. Kurbatov, M. A. Sirotina, N. V. Naryzhnaya, L. N. Maslov
Summary: We investigated the impact of induced metabolic syndrome on the effectiveness of remote ischemic postconditioning in rats, as well as the involvement of leptin and corticosterone in arterial hypertension and reduced effectiveness of postconditioning. Metabolic syndrome was induced in rats using a high-carbohydrate high-fat diet and fructose solution. The results showed that metabolic syndrome led to obesity, arterial hypertension, impaired metabolism, hyperleptinemia, and moderate stress. There was a direct correlation between the severity of hypertension and levels of corticosterone and leptin in rats with metabolic syndrome.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Irina V. Kologrivova, Natalia V. Naryzhnaya, Olga A. Koshelskaya, Tatiana E. Suslova, Elena S. Kravchenko, Olga A. Kharitonova, Vladimir V. Evtushenko, Alla A. Boshchenko
Summary: The study aimed to compare morphological features of EAT adipocyte with inflammatory biomarkers and parameters of extracellular matrix remodeling in CAD patients. EAT adipocytes were obtained from intraoperative adipose tissue samples. Concentrations of sPLA2, LpPLA2, TNF-alpha, IL-1 beta, IL-6, IL-10, hsCRP, MMP-9, MMP-2, CTX-I, and TIMP-1 were measured. Patients were divided into two groups based on EAT adipocytes' size. Patients in group 2 had higher triglyceride, hsCRP, TNF-alpha, and sPLA2 concentrations, and a lower CTX-I concentration. TNF-alpha, sPLA2, and CTX-I were independent determinants of EAT adipocyte hypertrophy.
Article
Biochemistry & Molecular Biology
Sergey V. V. Popov, Alexandr V. V. Mukhomedzyanov, Leonid N. N. Maslov, Natalia V. V. Naryzhnaya, Boris K. K. Kurbatov, N. Rajendra Prasad, Nirmal Singh, Feng Fu, Viacheslav N. N. Azev
Summary: The search for new drugs for the treatment of acute myocardial infarction and reperfusion injury is urgent. Opioid peptides, such as deltorphin II, have been found to have a cardioprotective effect in reperfusion, and this study aimed to investigate the molecular mechanisms involved. The results showed that the cardioprotective effect of deltorphin II in reperfusion is mediated through the activation of the peripheral delta(2) opioid receptor, most likely located in cardiomyocytes.
Review
Pharmacology & Pharmacy
Leonid N. N. Maslov, Sergey V. V. Popov, Natalia V. V. Naryzhnaya, Alexandr V. V. Mukhomedzyanov, Boris K. K. Kurbatov, Ivan A. A. Derkachev, Alla A. A. Boshchenko, N. Rajendra Prasad, Huijie Ma, Yi Zhang, Galina Z. Z. Sufianova, Feng Fu, Jian-Ming Pei
Summary: The use of K-ATP channel openers (KCOs) can effectively prevent cardiac reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI). KCOs promote inhibition of cell death processes and stimulate autophagy. They also exhibit antiarrhythmic properties and prevent the development of the no-reflow phenomenon in animals with coronary artery occlusion and reperfusion.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Review
Cell Biology
Vyacheslav V. Ryabov, Evgenii V. Vyshlov, Leonid N. Maslov, Alexandr V. Mukhomedzyanov, Natalia V. Naryzhnaya, Alla A. Boshchenko, Aleksandra E. Gombozhapova, Julia O. Samoylova
Summary: Acute myocardial infarction (AMI) is the leading cause of death globally, necessitating the development of new and more effective approaches for treatment. Remote postconditioning (RPost) has shown promise in reducing infarct size, improving heart function, preventing apoptosis, and stimulating autophagy in animal models. Various mechanisms, including endogenous opioids, adenosine, kinases, and NO-synthase, may be involved in RPost. However, the efficacy of RPost in clinical practice remains inconclusive, with inconsistent results reported.
Review
Pharmacology & Pharmacy
Sergey V. Popov, Leonid N. Maslov, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Alexandr S. Gorbunov, Michail Kilin, Viacheslav N. Azev, Maria S. Khlestkina, Galina Z. Sufianova
Summary: The in-hospital mortality rate for patients with ST-segment elevation myocardial infarction (STEMI) is 5-6%. Therefore, there is a need to develop novel drugs that can reduce mortality in patients with acute myocardial infarction. Apelins could serve as the prototype for such drugs. Chronic administration of apelins has been shown to mitigate adverse myocardial remodeling in animals with myocardial infarction or pressure overload. The cardioprotective effect of apelins involves the inhibition of multiple pathways and processes, including apoptosis, ferroptosis, and the activation of various kinases and enzymes.
Review
Biochemistry & Molecular Biology
Natalia V. Naryzhnaya, Alexander V. Mukhomedzyanov, Maria Sirotina, Leonid N. Maslov, Boris K. Kurbatov, Alexander S. Gorbunov, Mikhail Kilin, Artur Kan, Andrey V. Krylatov, Yuri K. Podoksenov, Sergey V. Logvinov
Summary: Analysis of data and studies shows that activation of peripheral & delta;(2)-opioid receptor (& delta;(2)-OR) can increase cardiac tolerance to reperfusion, and this receptor is found in cardiomyocytes. Endogenous opioids do not regulate cardiac resistance to reperfusion. The infarct-limiting effect of & delta;(2)-OR agonist deltorphin II depends on activation of several protein kinases, including PKC & delta;, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are sarcolemmal K-ATP channels and the MPT pore.
