Design, synthesis, and cytostatic activity of novel pyrazine sorafenib analogs

Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents

(2015) Yu Jiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regorafenib

(2014) Daniel J. Crona et al.   ANNALS OF PHARMACOTHERAPY

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents

(2014) Chenshu Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents

(2014) Mingze Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship Studies of Pyrazolo[3,4-d]pyrimidine Derivatives Leading to the Discovery of a Novel Multikinase Inhibitor That Potently Inhibits FLT3 and VEGFR2 and Evaluation of Its Activity against Acute Myeloid Leukemia in Vitro and in Vivo

(2013) Ling-Ling Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors

(2012) Wenhu Zhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological activities of sorafenib derivatives as antitumor agents

(2012) Jianwen Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines

(2012) Jean-Yves Winum et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Second-Line Therapies in Hepatocellular Carcinoma: Emergence of Resistance to Sorafenib

(2012) A. Villanueva et al.   CLINICAL CANCER RESEARCH

Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties

(2012) Elena L. Luzina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

(2012) Željka Babić et al.   MOLECULES

Hematologic toxicities in cancer patients treated with the multi-tyrosine kinase sorafenib: A meta-analysis of clinical trials

(2011) Fabio A.B. Schutz et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

(2010) Min Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues

(2008) Tatjana Gazivoda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS