Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study
Authors
Keywords
<em class=EmphasisTypeItalic >Hypericum perforatum</em>, Hypericin, Hyperforin, CYP3A4 mRNA expression, Cytotoxic activity, Hepatic cell lines, in vitro study
Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 25, Issue 12, Pages 2999-3010
Publisher
Springer Nature
Online
2016-09-20
DOI
10.1007/s00044-016-1702-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Dual Effects of Ketoconazole cis-Enantiomers on CYP3A4 in Human Hepatocytes and HepG2 Cells
- (2014) Aneta Novotná et al. PLoS One
- Glucocorticoids regulate metallothionein-1/2 expression in rat choroid plexus: effects on apoptosis
- (2013) A. Martinho et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions
- (2013) Emilio Russo et al. PHYTOTHERAPY RESEARCH
- Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen
- (2012) Kiumars Shahrokh et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
- (2012) H. H. J. Gerets et al. CELL BIOLOGY AND TOXICOLOGY
- Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review
- (2012) Pius Fasinu et al. CURRENT DRUG METABOLISM
- Stress and Glucocorticoids Increase Transthyretin Expression in Rat Choroid Plexus via Mineralocorticoid and Glucocorticoid Receptors
- (2012) A. Martinho et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes
- (2010) Juho Hokkanen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Hypericins as Potential Leads for New Therapeutics
- (2010) Anastasia Karioti et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A computational study of CYP3A4 mediated drug interaction profiles for anti-HIV drugs
- (2010) Jayakanthan Mannu et al. JOURNAL OF MOLECULAR MODELING
- Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification
- (2010) Danyel G. J. Jennen et al. TOXICOLOGICAL SCIENCES
- In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
- (2009) V. Chu et al. DRUG METABOLISM AND DISPOSITION
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- St. John’s Wort – an Overview
- (2009) Klaus Linde FORSCHENDE KOMPLEMENTARMEDIZIN
- Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical
- (2008) Michael Sinz et al. AAPS Journal
- In Vitro Studies are Sometimes Better than Conventional Human Pharmacokinetic In Vivo Studies in Assessing Bioequivalence of Immediate-Release Solid Oral Dosage Forms
- (2008) James E. Polli AAPS Journal
- In vitro Inhibition of CYP3A4 Metabolism and P-Glycoprotein-Mediated Transport by Trade Herbal Products
- (2008) Bent H. Hellum et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4
- (2008) Shu-Feng Zhou CURRENT DRUG METABOLISM
- Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies
- (2008) K. P. Kanebratt et al. DRUG METABOLISM AND DISPOSITION
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started