Pharmacophore and docking-based hierarchical virtual screening for the designing of aldose reductase inhibitors: synthesis and biological evaluation

Evaluation of ranirestat for the treatment of diabetic neuropathy

(2014) Nick Giannoukakis   Expert Opinion on Drug Metabolism & Toxicology

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Exploring the Role of Water Molecules for Docking and Receptor Guided 3D-QSAR Analysis of Naphthyridine Derivatives as Spleen Tyrosine Kinase (Syk) Inhibitors

(2012) Maninder Kaur et al.   Journal of Chemical Information and Modeling

Designing of new multi-targeted inhibitors of spleen tyrosine kinase (Syk) and zeta-associated protein of 70kDa (ZAP-70) using hierarchical virtual screening protocol

(2012) Maninder Kaur et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Structural Basis of Amino Pyrimidine Derivatives for Inhibitory Activity of PKC-θ: 3D-QSAR and Molecular Docking Studies

(2012) Om Silakari et al.   Molecular Informatics

An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 Å Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects

(2011) Holger Steuber   ChemMedChem

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

3D-QSAR (CoMFA and CoMSIA) and pharmacophore (GALAHAD) studies on the differential inhibition of aldose reductase by flavonoid compounds

(2010) Julio Caballero   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

3D-QSAR Studies on a Series of 5-Arylidine-2, 4-Thiazolidinediones as Aldose Reductase Inhibitors: A Self-Organizing Molecular Field Analysis Approach

(2010) Suresh Thareja et al.   Medicinal Chemistry

Oxidative stress: A cause and therapeutic target of diabetic complications

(2010) Eiichi Araki et al.   Journal of Diabetes Investigation

Aldose Reductase Enzyme and its Implication to Major Health Problems of the 21st Century

(2009) Polyxeni Alexiou et al.   CURRENT MEDICINAL CHEMISTRY

Artificial neural networks-based approach to design ARIs using QSAR for diabetes mellitus

(2009) Jagdish C. Patra et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

CoMFA and CoMSIA analysis of 2,4-thiazolidinediones derivatives as aldose reductase inhibitors

(2009) Hong-Yan Liu et al.   JOURNAL OF MOLECULAR MODELING

QSAR prediction of inhibition of aldose reductase for flavonoids

(2008) Andrew G. Mercader et al.   BIOORGANIC & MEDICINAL CHEMISTRY