Article
Biotechnology & Applied Microbiology
Benjamin Youenou, Amandine Chauviat, Chrisse Ngari, Valerie Poulet, Sylvie Nazaret
Summary: The study evaluated the antimicrobial activity of the preservative chlorphenesin and four antimicrobial cosmetic multifunctional ingredients against various strains of human opportunistic pathogens. The results showed that most multifunctional ingredients exhibited significant antimicrobial properties, but some strains of P. aeruginosa and Pluralibacter gergoviae were less sensitive to chlorphenesin and ethylhexylglycerin.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shang Dai, Rui Ye, Jianxiang Huang, Binqiang Wang, Zhenming Xie, Xinwen Ou, Ning Yu, Cheng Huang, Yuejin Hua, Ruhong Zhou, Bing Tian
Summary: This study elucidated the molecular mechanism and accumulation of nanoplastics within bacteria, and demonstrated the shielding and internalization effect of membrane lipids on toxic nanoplastics. This finding suggests the potential role of bacteria in plastic bioremediation.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maksim A. Kalutsky, Timur R. Galimzyanov, Rodion J. Molotkovsky
Summary: This study investigates the fusion mechanism of monolayer and bilayer membranes during the interaction between lipid droplets and peroxisomes. Through energy trajectory and molecular dynamics simulation, it is found that the stalk formed during the fusion process is energetically more stable and has a lower energy barrier compared to bilayer fusion. The further evolution of the stalk is dependent on the spontaneous curvature of the membrane, possibly related to the incorporation of free fatty acids.
Article
Multidisciplinary Sciences
Sukrut Kamerkar, Jagjeet Singh, Subham Tripathy, Hemangi Bhonsle, Mukesh Kumar, Roop Mallik
Summary: This study demonstrates real-time lipid and protein exchange across contacts between ER-mimicking membrane and lipid droplets (LDs) purified from rat liver, revealing a significant increase in LD-ER contacts in response to changes in metabolic state and immune system activation in vitro.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Elzbieta Jablonowska, Dorota Matyszewska, Ewa Nazaruk, Marlena Godlewska, Damian Gawel, Renata Bilewicz
Summary: The interactions of liquid-crystalline nanoparticles based on lipid-like surfactants with selected model lipid membranes were compared. PT cubosomes showed stronger interactions with lipid layers compared to GMO-based nanoparticles, leading to fluidization of model membranes. The membrane disrupting effect of cubosomes increased with longer exposure times and higher carrier concentrations.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Nanoscience & Nanotechnology
Priya Mandal, Rajendra P. Giri, Bridget M. Murphy, Sajal K. Ghosh
Summary: Research has shown that graphene oxide interacts strongly with positively charged phospholipids, weakly with zwitterionic lipids, and negligibly with negatively charged lipids. Additionally, the influence of graphene oxide is more pronounced at lower surface pressures.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Environmental
Anton Ribbenstedt, James M. Armitage, Felix Gunther, Jon A. Arnot, Steven T. J. Droge, Michael S. McLachlan
Summary: This study measured the bioconcentration factors (BCFs) of 10 anionic surfactants with different alkyl chain lengths and polar head groups in rainbow trout. The results showed that biotransformation was the dominant elimination mechanism, and there was a strong positive correlation between the BCF and the membrane lipid-water distribution ratio. The dataset is important for evaluating computational and experimental methods for assessing bioaccumulation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shilpaa Mukundan, Pooja Singh, Aditi Shah, Ranjeet Kumar, Kelly C. O'Neill, Claire L. Carter, David G. Russell, Selvakumar Subbian, Biju Parekkadan
Summary: Tuberculosis (TB) is a global public health concern affecting 10 million people worldwide. A new spheroid model with TB-infected THP-1 human monocyte/macrophage cells showed higher levels of inflammatory factors, growth factors, and lipid deposition compared to non-infected controls. This model also demonstrated varying responses to drugs Isoniazid and Rifampicin when infected with different strains of Mycobacterium tuberculosis. Co-culturing PBMCs and NHLF in this spheroid model holds promise for new disease modeling and therapeutic discovery strategies.
Article
Biochemistry & Molecular Biology
Stephanie Andrade, Joana Angelica Loureiro, Maria do Carmo Pereira
Summary: The study aimed to evaluate the effect of GA on preventing Aβ aggregation and disrupting fibrils, revealing its strong anti-amyloidogenic properties in a cell membrane-like environment. While no impact on inhibiting Aβ fibrillation was found, in vitro neuronal membranes appeared to modulate GA-induced Aβ fibril disaggregation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Trela-Makowej, Monika Leskiewicz, Jerzy Kruk, Andrzej Zadlo, Agnieszka Basta-Kaim, Renata Szymanska
Summary: This study compares the inhibition of lipid peroxidation by various tocochromanols in liposomes and demonstrates their potential neuroprotective role on a human neuroblastoma cell line. The results indicate the different biological activities of vitamin E homologues and suggest their potential application in treating neurodegenerative diseases.
Article
Food Science & Technology
Zhiling Tang, Haiming Chen, Ming Zhang, Zhuye Fan, Qiuping Zhong, Weijun Chen, Yong-Huan Yun, Wenxue Chen
Summary: This study investigates the antibacterial activity and mechanism of 3-carene against the meat spoilage bacterium P. lundensis, finding that it destroys cellular structures, inhibits metabolism, and affects vital proteins. Moreover, 3-carene can inhibit the growth of P. lundensis in pork, making it a potential tool for meat preservation.
Article
Chemistry, Applied
Yu-Ju Lin, Zijin Qin, Chad M. Paton, Douglas M. Fox, Fanbin Kong
Summary: The study found that CNC may not penetrate the small intestinal lining and could be used as a functional supplement.
CARBOHYDRATE POLYMERS
(2021)
Article
Biophysics
Michalina Zaborowska, Damian Dziubak, Philippe Fontaine, Dorota Matyszewska
Summary: The more lipophilic anthracycline idarubicin penetrates cholesterol monolayers more effectively than daunorubicin due to the formation of IDA-cholesterol arrangements at the interface. This increased interaction of IDA towards cholesterol allows the drug to penetrate the layer more efficiently without its removal.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Anita Wnetrzak, Anna Chachaj-Brekiesz, Alicja Stepniak, Jan Kobierski, Patrycja Dynarowicz-Latka
Summary: This study investigated the effects of three different oxysterols on lipid raft environments using experimental and theoretical approaches. The results showed that 25-OH stabilized the lipid raft, while 7 beta-OH and 7-K destabilized the raft and induced cell death.
CHEMISTRY AND PHYSICS OF LIPIDS
(2022)
Article
Chemistry, Applied
Lisa Myrseth Hemmingsen, Barbara Giordani, Ann Kristin Pettersen, Beatrice Vitali, Purusotam Basnet, Natasa Skalko-Basnet
Summary: The incorporation of chlorhexidine (CHX) liposomes into chitosan hydrogel significantly enhances its antimicrobial activity, leading to effective eradication of bacteria and biofilms, with potential therapeutic applications for skin infections.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Raja Narayanasamy, Dandamudi Usharani, Ram Rajasekharan
Summary: This study investigated the role of ABHD16B in lipid metabolism. The overexpression of ABHD16B was found to decrease cellular triacylglycerol levels and increase phospholipid synthesis in yeast cells. Additionally, ABHD16B overexpression led to a reduction in lipid droplets and significant modifications in fatty acid composition. These findings highlight the importance of ABHD16B in lipid homeostasis and provide insights into its regulatory function in cellular lipid metabolism.
CHEMISTRY AND PHYSICS OF LIPIDS
(2024)