Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

(2023) Yang Yang et al.   ACTA NEUROPATHOLOGICA

ELI trifocal microscope: a precise system to prepare target cryo-lamellae for in situ cryo-ET study

(2023) Shuoguo Li et al.   NATURE METHODS

Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation

(2023) Weixing Li et al.   NATURE METHODS

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

(2023) Itika Saha et al.   Nature Communications

Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice

(2023) Steven S. Hou et al.   Nature Biomedical Engineering

Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques

(2023) Yangyang Cao et al.   ACS Chemical Neuroscience

Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy

(2023) Shengnan Zhang et al.   Journal of the American Chemical Society

Cryo-electron tomography on focused ion beam lamellae transforms structural cell biology

(2023) Casper Berger et al.   NATURE METHODS

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

(2023) Andrew M. Stern et al.   NEURON

EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains

(2023) Hyunjun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions

(2023) Myungwoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural polymorphism and cytotoxicity of brain‐derived β‐amyloid extracts

(2023) Kenana Al Adem et al.   PROTEIN SCIENCE

Design of a selective and water-soluble fluorescent probe targeting Tau fibrils for intracellular and in vivo imaging

(2023) Liang Ji et al.   SENSORS AND ACTUATORS B-CHEMICAL

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography

(2023) Shuoguo Li et al.   Communications Biology

Radio Signals from Live Cells: The Coming of Age of In-Cell Solution NMR

(2022) Enrico Luchinat et al.   CHEMICAL REVIEWS

Cryo-EM in molecular and cellular biology

(2022) Helen R. Saibil   MOLECULAR CELL

Label-free visual proteomics: Coupling MS- and EM-based approaches in structural biology

(2022) Oleg Klykov et al.   MOLECULAR CELL

Cryo-EM structures of amyloid-β 42 filaments from human brains

(2022) Yang Yang et al.   SCIENCE

Better, Faster, Cheaper: Recent Advances in Cryo–Electron Microscopy

(2022) Eugene Y.D. Chua et al.   Annual Review of Biochemistry

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases

(2022) Andrew Chang et al.   CELL

1H-Detected Biomolecular NMR under Fast Magic-Angle Spinning

(2022) Tanguy Le Marchand et al.   CHEMICAL REVIEWS

In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale

(2022) Francois-Xavier Theillet   CHEMICAL REVIEWS

A solvatofluorochromic dye as a fluorescent lifetime-based probe of β-amyloid aggregation

(2022) Laura Espinar-Barranco et al.   DYES AND PIGMENTS

Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons

(2022) Henrick Riemenschneider et al.   EMBO REPORTS

Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues

(2022) Ethan J. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent formation of TMEM106B amyloid filaments in human brains

(2022) Manuel Schweighauser et al.   NATURE

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43

(2022) Yi Xiao Jiang et al.   NATURE

Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases

(2022) Dan Li et al.   NATURE REVIEWS NEUROSCIENCE

Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy

(2022) Sofia Lövestam et al.   eLife

Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer’s Disease

(2022) Himanshu Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils

(2022) Matthew D. Watson et al.   JOURNAL OF MOLECULAR BIOLOGY

Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

(2022) Youqi Tao et al.   Nature Communications

Solvatochromic Cellular Stress Sensors Reveal the Compactness Heterogeneity and Dynamics of Aggregated Proteome

(2022) Qiuxuan Xia et al.   ACS Sensors

Using reporters of different misfolded proteins reveals differential strategies in processing protein aggregates

(2022) Kara L. Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using mass spectrometry‐based methods to understand amyloid formation and inhibition of alpha‐synuclein and amyloid beta

(2022) Wesley J. Wagner et al.   MASS SPECTROMETRY REVIEWS

Structures of α-synuclein filaments from human brains with Lewy pathology

(2022) Yang Yang et al.   NATURE

Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies

(2022) Michael J. Morten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-cell NMR: Why and how?

(2022) Francois-Xavier Theillet et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques

(2022) Jia Miao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications

(2022) Liliana Malinovska et al.   Nature Protocols

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

(2022) Gurvir S. Virdi et al.   npj Parkinsons Disease

Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure

(2022) Xiang Li et al.   iScience

Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease

(2021) Dan Li et al.   Nature Chemical Biology

Characterizing proteins in a native bacterial environment using solid-state NMR spectroscopy

(2021) Siddarth Narasimhan et al.   Nature Protocols

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue

(2021) Ujjayini Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advanced In Vivo Cross-Linking Mass Spectrometry Platform to Characterize Proteome-Wide Protein Interactions

(2021) Martial Rey et al.   ANALYTICAL CHEMISTRY

Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43

(2021) Qiuye Li et al.   Nature Communications

Fluorescent Probe for Selective Imaging of α-Synuclein Fibrils in Living Cells

(2021) Pankaj Gaur et al.   ACS Chemical Neuroscience

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

(2021) Yang Shi et al.   ACTA NEUROPATHOLOGICA

Rational Design of Crystallization Induced Emission Probes to Detect Amorphous Protein Aggregation in Live Cells

(2021) Di Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell‐Free Expression Systems

(2021) Abhinav Dubey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enabling Photoactivated Cross-linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-cleavable Cross-linkers

(2021) Craig Gutierrez et al.   MOLECULAR & CELLULAR PROTEOMICS

The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3

(2021) Xialian Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding

(2021) Houfang Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ architecture of neuronal α-Synuclein inclusions

(2021) Victoria A. Trinkaus et al.   Nature Communications

Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue

(2021) Benjamin Lochocki et al.   Communications Biology

Live-cell ATR-FTIR spectroscopy as a novel bioanalytical tool for cell glucose metabolism research

(2021) Anchisa Poonprasartporn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems

(2021) Ellie I. James et al.   CHEMICAL REVIEWS

Towards Visual Proteomics at High Resolution

(2021) Felix J.B. Bäuerlein et al.   JOURNAL OF MOLECULAR BIOLOGY

Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils

(2021) Ayesha Wickramasinghe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonrefoldability is Pervasive Across the E. coli Proteome

(2021) Philip To et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potential of Raman spectroscopic techniques to study proteins

(2021) Nikki Kuhar et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

“Turn-On” Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer’s Disease: Rational Design, Synthesis, and Molecular Docking

(2021) Ahmed A. Elbatrawy et al.   ACS Sensors

Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

(2021) Li-Qiang Wang et al.   Science Advances

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

(2021) Jesús G. Galaz-Montoya et al.   Communications Biology

Hsp40 Affinity to Identify Proteins Destabilized by Cellular Toxicant Exposure

(2021) Guy M. Quanrud et al.   ANALYTICAL CHEMISTRY

A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells

(2021) Wang Wan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2021) Tamta Arakhamia et al.   CELL

Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences

(2021) Renze Ma et al.   JOURNAL OF PROTEOME RESEARCH

In-Cell Sensitivity-Enhanced NMR of Intact Viable Mammalian Cells

(2021) Rupam Ghosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation

(2021) Dangliang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Whole-cell organelle segmentation in volume electron microscopy

(2021) Larissa Heinrich et al.   NATURE

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

Structure of pathological TDP-43 filaments from ALS with FTLD

(2021) Diana Arseni et al.   NATURE

Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients

(2021) Ujjayini Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A label-free fluorescent probe for dynamic in situ visualization of amyloid-β peptides aggregation

(2021) Cen Ding et al.   SENSORS AND ACTUATORS B-CHEMICAL

The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein

(2021) Yunpeng Sun et al.   Nature Communications

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

(2021) Nathan Riguet et al.   Nature Communications

Construction of a Highly Sensitive Thiol‐Reactive AIEgen‐Peptide Conjugate for Monitoring Protein Unfolding and Aggregation in Cells

(2021) Soheila Sabouri et al.   Advanced Healthcare Materials

Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity

(2021) Irene Riera-Tur et al.   Life Science Alliance

Amyloid‐β Oligomer‐Targeted Gadolinium‐Based NIR/MR Dual‐Modal Theranostic Nanoprobe for Alzheimer's Disease

(2020) Chengke Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination

(2020) Dan Li et al.   BIOCHEMISTRY

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Identifying drug targets in tissues and whole blood with thermal-shift profiling

(2020) Jessica Perrin et al.   NATURE BIOTECHNOLOGY

Missing regions within the molecular architecture of human fibrin clots structurally resolved by XL-MS and integrative structural modeling

(2020) Oleg Klykov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live-Cell Imaging and Quantification of PolyQ Aggregates by Stimulated Raman Scattering of Selective Deuterium Labeling

(2020) Kun Miao et al.   ACS Central Science

Validating STAT Protein-inhibitor Interactions using Biochemical and Cellular Thermal Shift Assays

(2020) Sanaz Attarha et al.   ACS Chemical Biology

A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design

(2020) Wei-Ling Chen et al.   BIOCHEMISTRY

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

(2020) Yunpeng Sun et al.   CELL RESEARCH

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

(2020) Chuchu Wang et al.   Nature Communications

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

(2020) Kun Zhao et al.   Nature Communications

When Small becomes Too Big: Expanding the Use of In‐Cell Solid‐State NMR Spectroscopy

(2020) Siddarth Narasimhan et al.   ChemPlusChem

Fluorescent β-ketoenole AmyGreen dye for visualization of amyloid components of bacterial biofilms

(2020) Olena Moshynets et al.   Methods and Applications in Fluorescence

General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein

(2020) Longgang Jia et al.   ACS Applied Materials & Interfaces

The In Situ Structure of Parkinson’s Disease-Linked LRRK2

(2020) Reika Watanabe et al.   CELL

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

(2020) Li-Qiang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

(2020) Kun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environment-Sensitive Probes for Illuminating Amyloid Aggregation In Vitro and in Zebrafish

(2020) Francisco Fueyo-González et al.   ACS Sensors

In‐cell NMR of functional riboswitch aptamers in eukaryotic cells

(2020) P. Broft et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy to Control Viscosity Sensitivity of Molecular Rotor‐Based Fluorophores

(2020) Songtao Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The promise and the challenges of cryo‐electron tomography

(2020) Martin Turk et al.   FEBS LETTERS

AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells

(2020) Charles H. Wolstenholme et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-particle cryo-EM at atomic resolution

(2020) Takanori Nakane et al.   NATURE

Atomic-resolution protein structure determination by cryo-EM

(2020) Ka Man Yip et al.   NATURE

Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells

(2020) Felix J.B. Bäuerlein et al.   TRENDS IN CELL BIOLOGY

Topaz-Denoise: general deep denoising models for cryoEM and cryoET

(2020) Tristan Bepler et al.   Nature Communications

Length-Dependent Distinct Cytotoxic Effect of Amyloid Fibrils beyond Optical Diffraction Limit Revealed by Nanoscopic Imaging

(2020) Zhongju Ye et al.   ACS Nano

Monitoring the Dynamics of Proteome Aggregation in Live Cells Using a Solubilized and Noncovalent Analogue of Fluorescent Protein Chromophores

(2020) Wang Wan et al.   ANALYTICAL CHEMISTRY

Raman spectral imaging of 13C2H15N-labeled α-synuclein amyloid fibrils in cells

(2020) Matthew D. Watson et al.   BIOPHYSICAL CHEMISTRY

Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation

(2020) Xueli Wang et al.   TALANTA

Rational Design of Near-Infrared AIE-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultra-Sensitivity and High-Fidelity

(2019) Wei Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR

(2019) Panagis Polykretis et al.   Redox Biology

Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations

(2019) Nicholas I. Brodie et al.   PLoS Computational Biology

Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome

(2019) Ethan J. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast pressure-jump all-atom simulations and experiments reveal site-specific protein dehydration-folding dynamics

(2019) Maxim B. Prigozhin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Growth-driven displacement of protein aggregates along the cell length ensures partitioning to both daughter cells in Caulobacter crescentus

(2019) Frederic D. Schramm et al.   MOLECULAR MICROBIOLOGY

Challenges and opportunities in cryo-EM single-particle analysis

(2019) Dmitry Lyumkis   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells

(2019) Takashi Tanaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA)

(2019) Lingyun Dai et al.   Annual Review of Biochemistry

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

Advances in cryo-electron tomography and subtomogram averaging and classification

(2019) Peijun Zhang   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

(2019) Xiaodan Ni et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of Residue Specific Protein Folding and Unfolding Dynamics in Cells

(2019) Xiangfei Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

(2019) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

(2019) Qin Cao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

(2019) Dailu Chen et al.   Nature Communications

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

(2019) Silvia Bonfanti et al.   Scientific Reports

Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

(2019) Tyler R. Lambeth et al.   ACS Central Science

Kinetic Transition in Amyloid Assembly as a Screening Assay for Oligomer-Selective Dyes

(2019) Jeremy Barton et al.   Biomolecules

Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging

(2019) Florian KM Schur   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

(2019) Tze Cin Owyong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High intracellular stability of the spidroin N‐terminal domain in spite of abundant amyloidogenic segments revealed by in‐cell hydrogen/deuterium exchange mass spectrometry

(2019) Margit Kaldmäe et al.   FEBS Journal

Order, Disorder, and Reorder State of Lysozyme: Aggregation Mechanism by Raman Spectroscopy

(2019) Sandip Dolui et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

Dynamic Nuclear Polarization-Enhanced Biomolecular NMR Spectroscopy at High Magnetic Field with Fast Magic-Angle Spinning

(2018) Kristaps Jaudzems et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cryo-electron microscopy for structural analysis of dynamic biological macromolecules

(2018) Kazuyoshi Murata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Fluorescence-Based Sensor Assay that Monitors General Protein Aggregation in Human Cells

(2018) Marisa Pereira et al.   Biotechnology Journal

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

Coexisting order and disorder within a common 40-residue amyloid-β fibril structure in Alzheimer's disease brain tissue

(2018) Ujjayini Ghosh et al.   CHEMICAL COMMUNICATIONS

Production of isotope-labeled proteins in insect cells for NMR

(2018) Bastian Franke et al.   JOURNAL OF BIOMOLECULAR NMR

Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer

(2018) He Meng et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence

(2018) Yu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular and structural architecture of polyQ aggregates in yeast

(2018) Anselm Gruber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioimaging: Dual-Modal NIR-Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid-β Species In Vivo (Small 28/2018)

(2018) Yinhui Li et al.   Small

Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

(2018) Jonathan Pansieri et al.   Chemical Science

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

(2018) Michael J. Capper et al.   Nature Communications

A biosensor-based framework to measure latent proteostasis capacity

(2018) Rebecca J. Wood et al.   Nature Communications

N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression

(2018) Gen Matsumoto et al.   Scientific Reports

A Fluorescence-Based Sensor Assay that Monitors General Protein Aggregation in Human Cells

(2018) Marisa Pereira et al.   Biotechnology Journal

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

In-cell NMR within budding yeast reveals cytoplasmic masking of hydrophobic residues of FG repeats

(2018) Kathryn P. Wall et al.   BIOPHYSICAL JOURNAL

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Time-Resolved NMR Analysis of Proteolytic α-Synuclein Processing in vitro and in cellulo

(2018) Antonio Limatola et al.   PROTEOMICS

Single-particle cryo-EM—How did it get here and where will it go

(2018) Yifan Cheng   SCIENCE

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

High-resolution NMR studies of antibiotics in cellular membranes

(2018) João Medeiros-Silva et al.   Nature Communications

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Unravelling molecular complexity in structural cell biology

(2018) Stefan Pfeffer et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau

(2018) Shengnan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly

(2018) Meng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multi-parametric imaging

(2018) Meng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In-Cell NMR Spectroscopy of Intrinsically Disordered Proteins

(2018) Nicholas Sciolino et al.   PROTEOMICS

Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy

(2017) Jessica D. Flynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX

(2017) Fang Liu et al.   JOURNAL OF PROTEOME RESEARCH

Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy

(2017) Cecilia Pinto et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

(2017) Arnaldo L. Serrano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of in Vivo Tau Tangle-Selective Near-Infrared Fluorophores: Expanding the BODIPY Universe

(2017) Peter Verwilst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry

(2017) Simone Schopper et al.   Nature Protocols

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability

(2017) Pascal Leuenberger et al.   SCIENCE

Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species

(2017) Yuyan Li et al.   Chemical Science

Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP

(2017) O. Klementieva et al.   Nature Communications

A thiol probe for measuring unfolded protein load and proteostasis in cells

(2017) Moore Z. Chen et al.   Nature Communications

α-Synuclein: Multiple System Atrophy Prions

(2017) Amanda L. Woerman et al.   Cold Spring Harbor Perspectives in Medicine

In-cell NMR: a topical review

(2017) Enrico Luchinat et al.   IUCrJ

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

(2017) Enrico Luchinat et al.   Scientific Reports

Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease

(2016) Andreas Nabers et al.   ANALYTICAL CHEMISTRY

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

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EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

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The amyloid hypothesis of Alzheimer's disease at 25 years

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Structural biology applications of solid state MAS DNP NMR

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Luminescent Ru(II) Phenanthroline Complexes as a Probe for Real-Time Imaging of Aβ Self-Aggregation and Therapeutic Applications in Alzheimer’s Disease

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Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome

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Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis

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Unprecedented Dual Light-Switching Response of a Metal Dipyridophenazine Complex toward Amyloid-β Aggregation

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Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1–42 Aggregation

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Electrostatic Contributions to Protein Quinary Structure

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Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Structural disorder of monomeric α-synuclein persists in mammalian cells

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Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells

(2016) Letizia Barbieri et al.   Nature Protocols

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

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Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

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Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

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Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells

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Improved in-cell structure determination of proteins at near-physiological concentration

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Probing Protein Quinary Interactions by In-Cell Nuclear Magnetic Resonance Spectroscopy

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Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

(2015) Kendra K. Frederick et al.   CELL

Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1

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Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

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In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

(2015) Hiroyuki Watanabe et al.   CHEMICAL COMMUNICATIONS

HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution

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Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation

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Global Analysis of Protein Folding Thermodynamics for Disease State Characterization

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Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells

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Chemical Fluorescent Probe for Detection of Aβ Oligomers

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Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR

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Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

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Thermodynamics of protein destabilization in live cells

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Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation

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The Synaptic Function of α-Synuclein

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Hydrogen/Deuterium Exchange-Protected Oligomers Populated during Aβ Fibril Formation Correlate with Neuronal Cell Death

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Monitoring Antibody Aggregation in Early Drug Development Using Raman Spectroscopy and Perturbation-Correlation Moving Windows

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Live-Cell Quantitative Imaging of Proteome Degradation by Stimulated Raman Scattering

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Surface Characterization of Insulin Protofilaments and Fibril Polymorphs Using Tip-Enhanced Raman Spectroscopy (TERS)

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Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

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Cryoprotection of lipid membranes for high-resolution solid-state NMR studies of membrane peptides and proteins at low temperature

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Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

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Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

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Global analysis of protein structural changes in complex proteomes

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Monitoring Protein Misfolding by Site-Specific Labeling of Proteins In Vivo

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Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting

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Tracking cancer drugs in living cells by thermal profiling of the proteome

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Proteostasis impairment in protein-misfolding and -aggregation diseases

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In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants

(2014) Enrico Luchinat et al.   Nature Communications

Detection and structural characterization of insulin prefibrilar oligomers using surface enhanced Raman spectroscopy

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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

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Structural biology in situ—the potential of subtomogram averaging

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Dissection of Conformational Conversion Events during Prion Amyloid Fibril Formation Using Hydrogen Exchange and Mass Spectrometry

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Temporal Variation of a Protein Folding Energy Landscape in the Cell

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High-Resolution Heteronuclear Multidimensional NMR of Proteins in Living Insect Cells Using a Baculovirus Protein Expression System

(2013) Jumpei Hamatsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

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Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

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Properties of native brain α-synuclein

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Atomic-resolution monitoring of protein maturation in live human cells by NMR

(2013) Lucia Banci et al.   Nature Chemical Biology

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

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Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

(2013) Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

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M2 Proton Channel Structural Validation from Full-Length Protein Samples in Synthetic Bilayers and E. coli Membranes

(2012) Yimin Miao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

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Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

(2012) Carlo Camilloni et al.   BIOCHEMISTRY

Imaging Nanometer-Sized α-Synuclein Aggregates by Superresolution Fluorescence Localization Microscopy

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In-Cell Solid-State NMR as a Tool to Study Proteins in Large Complexes

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Simple and inexpensive incorporation of 19F-Tryptophan for protein NMR spectroscopy

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Rapid Perturbation of Free-Energy Landscapes: From In Vitro to In Vivo

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Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells

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RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Fast Photochemical Oxidation of Proteins and Mass Spectrometry Follow Submillisecond Protein Folding at the Amino-Acid Level

(2012) Jiawei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Proteins in Eukaryotic Compartments

(2012) Karl Bertrand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation

(2012) Erin C Strickland et al.   Nature Protocols

Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)

(2012) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular solid-state nuclear magnetic resonance spectroscopy

(2012) M. Renault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Protein-Folding Problem, 50 Years On

(2012) K. A. Dill et al.   SCIENCE

LIMITING FACTORS IN SINGLE PARTICLE CRYO ELECTRON TOMOGRAPHY

(2012) Mikhail Kudryashev et al.   Computational and Structural Biotechnology Journal

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

(2011) Willy M. Chang et al.   ACS Chemical Neuroscience

Conformer-Specific Hydrogen Exchange Analysis of Aβ(1–42) Oligomers by Top-Down Electron Capture Dissociation Mass Spectrometry

(2011) Jingxi Pan et al.   ANALYTICAL CHEMISTRY

13C Direct-Detection Biomolecular NMR Spectroscopy in Living Cells

(2011) Ivano Bertini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

Mass Spectrometry-Based Protein Footprinting Characterizes the Structures of Oligomeric Apolipoprotein E2, E3, and E4

(2011) Brian Gau et al.   BIOCHEMISTRY

Aggregation-induced emission

(2011) Yuning Hong et al.   CHEMICAL SOCIETY REVIEWS

A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo

(2011) Gabriele S. Kaminski Schierle et al.   CHEMPHYSCHEM

A thienoquinoxaline and a styryl-quinoxaline as new fluorescent probes for amyloid-β fibrils

(2011) Hanane Benzeid et al.   COMPTES RENDUS CHIMIE

Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins

(2011) Lewis E. Kay et al.   JOURNAL OF MAGNETIC RESONANCE

Sensing Amyloid-β Aggregation Using Luminescent Dipyridophenazine Ruthenium(II) Complexes

(2011) Nathan P. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Situ Structural Characterization of a Recombinant Protein in Native Escherichia coli Membranes with Solid-State Magic-Angle-Spinning NMR

(2011) Riqiang Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescence Ratiometry and Fluorescence Lifetime Imaging: Using a Single Molecular Sensor for Dual Mode Imaging of Cellular Viscosity

(2011) Xiaojun Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Situ Measurements of the Formation and Morphology of Intracellular β-Amyloid Fibrils by Super-Resolution Fluorescence Imaging

(2011) Gabriele S. Kaminski Schierle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics

(2011) Yuning Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectral Unmixing Imaging of Wavelength-Responsive Fluorescent Probes: An Application for the Real-Time Report of Amyloid Beta Species in Alzheimer’s Disease

(2011) Chongzhao Ran et al.   MOLECULAR IMAGING AND BIOLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

(2011) Lucy A Woods et al.   Nature Chemical Biology

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils

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In-cell NMR in E. coli to Monitor Maturation Steps of hSOD1

(2011) Lucia Banci et al.   PLoS One

Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange

(2010) Natàlia Carulla et al.   ACCOUNTS OF CHEMICAL RESEARCH

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

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Development of a Novel Cross-linking Strategy for Fast and Accurate Identification of Cross-linked Peptides of Protein Complexes

(2010) Athit Kao et al.   MOLECULAR & CELLULAR PROTEOMICS

Highly sensitive amyloid detection enabled by thioflavin T dimers

(2010) Luoheng Qin et al.   Molecular BioSystems

Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

(2010) Christian Bleiholder et al.   Nature Chemistry

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

In vivo near-infrared fluorescence imaging of cancer with nanoparticle-based probes

(2010) Xiaoxiao He et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A bioreactor for in-cell protein NMR

(2009) Naima G. Sharaf et al.   JOURNAL OF MAGNETIC RESONANCE

Guidelines for the use of band-selective radiofrequency pulses in hetero-nuclear NMR: Example of longitudinal-relaxation-enhanced BEST-type 1H–15N correlation experiments

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Observation of NMR Signals from Proteins Introduced into Living Mammalian Cells by Reversible Membrane Permeabilization Using a Pore-Forming Toxin, Streptolysin O

(2009) Shinji Ogino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

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Protein19F NMR inEscherichia coli

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Protein structure determination in living cells by in-cell NMR spectroscopy

(2009) Daisuke Sakakibara et al.   NATURE

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

(2009) Kohsuke Inomata et al.   NATURE

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic Analysis of Protein Stability and Ligand Binding Using a Chemical Modification- and Mass Spectrometry-Based Strategy

(2008) Graham M. West et al.   ANALYTICAL CHEMISTRY

Differential Dynamical Effects of Macromolecular Crowding on an Intrinsically Disordered Protein and a Globular Protein: Implications for In-Cell NMR Spectroscopy

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Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen exchange of monomeric α-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding inEscherichia coli

(2008) Robyn L. Croke et al.   PROTEIN SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE