NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy

NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathway

(2021) Jung-Eun Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells

(2020) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

Amygdalin alleviates renal injury by suppressing inflammation, oxidative stress and fibrosis in streptozotocin-induced diabetic rats

(2020) Jiawei Chen et al.   LIFE SCIENCES

Knockdown of TRIM27 expression suppresses the dysfunction of mesangial cells in lupus nephritis by FoxO1 pathway

(2019) Jinxi Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling

(2019) Fengjuan Huang et al.   Frontiers in Endocrinology

BML-111 attenuates high glucose-induced inflammation, oxidative stress and reduces extracellular matrix accumulation via targeting Nrf2 in rat glomerular mesangial cells

(2019) Xiaoming Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy

(2018) Kishore Reddy Katikireddy et al.   FREE RADICAL BIOLOGY AND MEDICINE

A1AR-mediated renal protection against ischemia/reperfusion injury is dependent on HSP27 induction

(2018) Bin Xiong et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

(2018) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism

(2018) Guang Liang et al.   KIDNEY INTERNATIONAL

Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression

(2017) Quanfang Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro

(2017) Xiangjun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The beneficial effects of zinc on diabetes-induced kidney damage in murine rodent model of type 1 diabetes mellitus

(2017) Fan Yang et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes

(2017) Siwei Zhang et al.   Experimental and Therapeutic Medicine

NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling

(2017) AiHua Shen et al.   Scientific Reports

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis

(2016) Qing Li et al.   Scientific Reports

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

TLR4 Activation Promotes Podocyte Injury and Interstitial Fibrosis in Diabetic Nephropathy

(2014) Jin Ma et al.   PLoS One

Nox as a target for diabetic complications

(2013) Yves Gorin et al.   CLINICAL SCIENCE

Sustained Wnt/β-Catenin Signaling Rescues High Glucose Induction of Transforming Growth Factor-β1-Mediated Renal Fibrosis

(2012) Cheng Ho et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells

(2011) S.-I. Lee et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

(2010) María T Grande et al.   Journal of Inflammation-London

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR4 Promotes Fibrosis but Attenuates Tubular Damage in Progressive Renal Injury

(2010) W. P. Pulskens et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease

(2010) Omar García-Sánchez et al.   KIDNEY INTERNATIONAL

Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications

(2010) Sridevi Devaraj et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of Mast Cells in Progressive Renal Diseases

(2008) S. R. Holdsworth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The pathogenesis of diabetic nephropathy

(2008) Suma Dronavalli et al.   Nature clinical practice. Endocrinology & metabolism