The destruction of mucosal barriers, epithelial remodeling, and impaired mucociliary clearance: possible pathogenic mechanisms of Pseudomonas aeruginosa and Staphylococcus aureus in chronic rhinosinusitis

Pathogenesis and treatment of chronic rhinosinusitis from the perspective of sinonasal epithelial dysfunction

(2023) Yuanqiong He et al.   Frontiers in Medicine

Molecular analysis of dominant paranasal sinus bacteria in patients with and without chronic rhinosinusitis

(2022) Zahra Chegini et al.   ARCHIVES OF MICROBIOLOGY

The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis

(2022) Zahra Chegini et al.   Cell Communication and Signaling

Advances in the Knowledge of the Underlying Airway Remodeling Mechanisms in Chronic Rhinosinusitis Based on the Endotypes: A Review

(2021) Kijeong Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis

(2021) Jannatul Ferdoush Tuli et al.   ALLERGY

An overview of possible pathogenesis mechanisms of Alternaria alternata in chronic rhinosinusitis and nasal polyposis

(2021) Mojtaba Didehdar et al.   MICROBIAL PATHOGENESIS

First contact: The role of respiratory cilia in host-pathogen interactions in the airways

(2020) Li Eon Kuek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Azithromycin and ciprofloxacin inhibit interleukin‐8 secretion without disrupting human sinonasal epithelial integrity in vitro

(2020) Dong‐Jin Lim et al.   International Forum of Allergy & Rhinology

Staphylococcus aureus biofilm exoproteins are cytotoxic to human nasal epithelial barrier in chronic rhinosinusitis

(2020) Beula Subashini Panchatcharam et al.   International Forum of Allergy & Rhinology

Staphylococcus aureus enterotoxin B disrupts nasal epithelial barrier integrity

(2020) Katleen Martens et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review

(2020) Zahra Chegini et al.   Annals of Clinical Microbiology and Antimicrobials

Interleukin-13 Alters Tight Junction Proteins Expression Thereby Compromising Barrier Function and Dampens Rhinovirus Induced Immune Responses in Nasal Epithelium

(2020) Zhi-Qun Huang et al.   Frontiers in Cell and Developmental Biology

Pseudomonas aeruginosa Exoprotein-Induced Barrier Disruption Correlates With Elastase Activity and Marks Chronic Rhinosinusitis Severity

(2019) Jian Li et al.   Frontiers in Cellular and Infection Microbiology

Histopathologic analysis in chronic rhinosinusitis: Impact on quality of life outcomes

(2019) Feng Wang et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Multiple airborne allergen-induced eosinophilic chronic rhinosinusitis murine model

(2019) Sang Chul Park et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Epithelial physical barrier defects in chronic rhinosinusitis

(2019) Jian Jiao et al.   Expert Review of Clinical Immunology

Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis

(2019) Gwanghui Ryu et al.   Current Opinion in Allergy and Clinical Immunology

Staphylococcus aureus Orchestrates Type 2 Airway Diseases

(2019) Andrea R. Teufelberger et al.   TRENDS IN MOLECULAR MEDICINE

The effect of neutrophil serine proteases on human nasal epithelial cell barrier function

(2019) Stephen Shih‐Teng Kao et al.   International Forum of Allergy & Rhinology

Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function?

(2019) Kazuto Tsukita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nasal epithelial barrier dysfunction increases sensitization and mast cell degranulation in the absence of allergic inflammation

(2019) Inge Kortekaas Krohn et al.   ALLERGY

Key role of the epithelium in chronic upper airways diseases

(2019) Sophie Gohy et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis

(2018) Brecht Steelant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Submucosal gland mucus strand velocity is decreased in chronic rhinosinusitis

(2018) Kiranya E. Tipirneni et al.   International Forum of Allergy & Rhinology

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

(2018) Yasuhiro Gon et al.   ALLERGOLOGY INTERNATIONAL

H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium

(2018) Tengfei Tian et al.   EXPERIMENTAL CELL RESEARCH

Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes

(2018) Ping-Ping Cao et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

In vitro characteristics of an airway barrier-disrupting factor secreted by Staphylococcus aureus

(2018) Jae Murphy et al.   International Forum of Allergy & Rhinology

Alternaria ‐induced barrier dysfunction of nasal epithelial cells: role of serine protease and reactive oxygen species

(2018) Seung‐Heon Shin et al.   International Forum of Allergy & Rhinology

Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease

(2017) Kathryn L. Pothoven et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro

(2017) Jae Murphy et al.   LARYNGOSCOPE

PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats

(2017) Zhiqiang Guo et al.   International Journal of Environmental Research and Public Health

Pemphigus

(2017) Michael Kasperkiewicz et al.   Nature Reviews Disease Primers

The Bacterial Microbiome in Chronic Rhinosinusitis: Richness, Diversity, Postoperative Changes, and Patient Outcomes

(2016) Edward John Cleland et al.   American Journal of Rhinology & Allergy

Lipoteichoic acids as a major virulence factor causing inflammatory responses via Toll-like receptor 2

(2016) Seok-Seong Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Role of TLRs in the production of chemical mediators in nasal polyp fibroblasts by fungi

(2016) Seung-Heon Shin et al.   AURIS NASUS LARYNX

Mitochondria in lung disease

(2016) Suzanne M. Cloonan et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of interleukin-33 in chronic rhinosinusitis

(2016) Dong-Kyu Kim et al.   THORAX

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

(2016) Mariena J. A. van der Plas et al.   Nature Communications

Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function

(2016) Robert J. Lee et al.   Scientific Reports

Reversal of cigarette smoke extract-induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation

(2016) Anuj Tharakan et al.   International Forum of Allergy & Rhinology

Involvement of Toll-Like Receptor 2 and Epidermal Growth Factor Receptor Signaling in Epithelial Expression of Airway Remodeling Factors

(2015) Tetsuya Homma et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis

(2015) Sudarshan Seshadri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Non-Eosinophilic Nasal Polyps Shows Increased Epithelial Proliferation and Localized Disease Pattern in the Early Stage

(2015) Dong-Kyu Kim et al.   PLoS One

Staphylococcus aureusimpairs the airway epithelial barrier in vitro

(2015) Zacki Malik et al.   International Forum of Allergy & Rhinology

Immunopathology of chronic rhinosinusitis

(2015) Atsushi Kato   ALLERGOLOGY INTERNATIONAL

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells

(2014) Kazuaki Nomura et al.   RESPIRATORY RESEARCH

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

(2014) S R Kim et al.   Cell Death & Disease

Effects of Fungi and Eosinophils on Mucin Gene Expression in Rhinovirus-Infected Nasal Epithelial Cells

(2014) Seung-Heon Shin et al.   Allergy Asthma & Immunology Research

Staphylococcus aureus enterotoxin B-induced endoplasmic reticulum stress response is associated with chronic rhinosinusitis with nasal polyposis

(2013) Yong-Min Kim et al.   CLINICAL BIOCHEMISTRY

The Development of Nasal Polyp Disease Involves Early Nasal Mucosal Inflammation and Remodelling

(2013) Juan Meng et al.   PLoS One

Bacterial-induced epithelial damage promotes fungal biofilm formation in a sheep model of sinusitis

(2013) Sam Boase et al.   International Forum of Allergy & Rhinology

Mucosal remodeling and reversibility in chronic rhinosinusitis

(2012) Ahmed Bassiouni et al.   Current Opinion in Allergy and Clinical Immunology

Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4

(2012) Michael B. Soyka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Regulation of murine sinonasal cilia function by microbial secreted factors

(2012) Jessica C. Shen et al.   International Forum of Allergy & Rhinology

Airway Mucus Function and Dysfunction

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Immunomodulatory Effect of Cytosine-Phosphate-Guanosine (CPG)-Oligonucleotides in Nonasthmatic Chronic Rhinosinusitis: An Explant Model

(2010) Lorwai Tan et al.   American Journal of Rhinology & Allergy

Staphylococcus Aureus Increases Cytokine and Matrix Metalloproteinase Expression in Nasal Mucosae of Patients with Chronic Rhinosinusitis and Nasal Polyps

(2010) Jong Hwan Wang et al.   American Journal of Rhinology & Allergy

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

TGF-β signaling and collagen deposition in chronic rhinosinusitis

(2009) Nicholas Van Bruaene et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS

(2009) D. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse model of Aspergillus and Alternaria induced rhinosinusitis

(2008) Byung-Hoon Ahn et al.   AURIS NASUS LARYNX

The bacterial superantigen and superantigen-like proteins

(2008) John D. Fraser et al.   IMMUNOLOGICAL REVIEWS

The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis

(2008) Ilknur Haberal Can et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES