Circuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease model

A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

(2023) Yefei Chen et al.   Neuroscience Bulletin

Parkinson and depression: review and outlook

(2022) Gerd Laux   JOURNAL OF NEURAL TRANSMISSION

Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques

(2022) Kei Oyama et al.   JOURNAL OF NEUROSCIENCE

Striatal synaptic adaptations in Parkinson's disease

(2022) Weixing Shen et al.   NEUROBIOLOGY OF DISEASE

Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders

(2021) Patrick H. Roseboom et al.   MOLECULAR THERAPY

D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects

(2020) Damon Young et al.   ACS Chemical Neuroscience

A common hub for sleep and motor control in the substantia nigra

(2020) Danqian Liu et al.   SCIENCE

Historical Perspective: Models of Parkinson’s Disease

(2020) Shyh Jenn Chia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fast and reversible neural inactivation in macaque cortex by optogenetic stimulation of GABAergic neurons

(2020) Abhishek De et al.   eLife

Distinct subnetworks of the thalamic reticular nucleus

(2020) Yinqing Li et al.   NATURE

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

(2020) Yuji Nagai et al.   NATURE NEUROSCIENCE

Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research

(2020) Guoping Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review

(2019) Klaus Seppi et al.   MOVEMENT DISORDERS

What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation

(2019) Andreas Klaus et al.   Annual Review of Neuroscience

An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway

(2019) Sho Aoki et al.   eLife

Hierarchical organization of cortical and thalamic connectivity

(2019) Julie A. Harris et al.   NATURE

Frontal cortex neuron types categorically encode single decision variables

(2019) Junya Hirokawa et al.   NATURE

Primate optogenetics: Progress and prognosis

(2019) Yasmine El-Shamayleh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

(2018) Julie Tordo et al.   BRAIN

Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits

(2018) Sabrina Sun et al.   CURRENT OPINION IN NEUROBIOLOGY

Genetic approaches to access cell types in mammalian nervous systems

(2018) Miao He et al.   CURRENT OPINION IN NEUROBIOLOGY

Contrast coding in the primary visual cortex depends on temporal contexts

(2018) Ji Dai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aberrant Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia

(2018) Michael B. Ryan et al.   Cell Reports

5-HT release in nucleus accumbens rescues social deficits in mouse autism model

(2018) Jessica J. Walsh et al.   NATURE

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

(2018) Jones G. Parker et al.   NATURE

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

The Emerging Evidence of the Parkinson Pandemic

(2018) E. Ray Dorsey et al.   Journal of Parkinsons Disease

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson’s disease therapy

(2017) Cristina Alcacer et al.   JOURNAL OF CLINICAL INVESTIGATION

The two-century journey of Parkinson disease research

(2017) Serge Przedborski   NATURE REVIEWS NEUROSCIENCE

Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum

(2017) Yasmine El-Shamayleh et al.   NEURON

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

(2017) Nicholas M. Kanaan et al.   Molecular Therapy-Nucleic Acids

Mu-ming Poo: China Brain Project and the future of Chinese neuroscience

(2017) Ling Wang   National Science Review

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Levodopa in Parkinson’s Disease: Current Status and Future Developments

(2017) Nicola Tambasco et al.   Current Neuropharmacology

Current and experimental treatments of Parkinson disease: A guide for neuroscientists

(2016) Wolfgang Oertel et al.   JOURNAL OF NEUROCHEMISTRY

A specific area of olfactory cortex involved in stress hormone responses to predator odours

(2016) Kunio Kondoh et al.   NATURE

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

rAAV-compatible MiniPromoters for restricted expression in the brain and eye

(2016) Charles N. de Leeuw et al.   Molecular Brain

A quantitative approach to developing Parkinsonian monkeys ( Macaca fascicularis ) with intracerebroventricular 1-methyl-4-phenylpyridinium injections

(2015) Hao Li et al.   JOURNAL OF NEUROSCIENCE METHODS

Modeling psychiatric disorders for developing effective treatments

(2015) Tobias Kaiser et al.   NATURE MEDICINE

Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function

(2015) Euiseok J. Kim et al.   NEURON

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

(2015) Weixing Shen et al.   NEURON

1-Methyl-4-Phenylpyridinium Stereotactic Infusion Completely and Specifically Ablated the Nigrostriatal Dopaminergic Pathway in Rhesus Macaque

(2015) Xiaoguang Lei et al.   PLoS One

Striatal Cholinergic Cell Ablation Attenuates L-DOPA Induced Dyskinesia in Parkinsonian Mice

(2014) L. Won et al.   JOURNAL OF NEUROSCIENCE

Dynamic Representation of the Temporal and Sequential Structure of Rhythmic Movements in the Primate Medial Premotor Cortex

(2014) D. A. Crowe et al.   JOURNAL OF NEUROSCIENCE

Enhancer biology and enhanceropathies

(2014) Edwin Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

(2013) Ji Dai et al.   CURRENT BIOLOGY

A Gαs DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

(2013) Martilias S Farrell et al.   NEUROPSYCHOPHARMACOLOGY

Modeling Parkinson's Disease in Primates: The MPTP Model

(2013) G. Porras et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Parkinson's Disease: Vertebrate Genetics

(2013) Y. Lee et al.   Cold Spring Harbor Perspectives in Medicine

A critique of available scales and presentation of the non-human primate dyskinesia rating scale

(2012) Susan H. Fox et al.   MOVEMENT DISORDERS

l-DOPA pharmacokinetics in the MPTP-lesioned macaque model of Parkinson's disease

(2012) Philippe Huot et al.   NEUROPHARMACOLOGY

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Rapid Target-Specific Remodeling of Fast-Spiking Inhibitory Circuits after Loss of Dopamine

(2011) Aryn H. Gittis et al.   NEURON

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Hallucinations in Parkinson disease

(2009) Nico J. Diederich et al.   Nature Reviews Neurology

Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain

(2009) Xue Han et al.   NEURON

Striatal Medium-Sized Spiny Neurons: Identification by Nuclear Staining and Study of Neuronal Subpopulations in BAC Transgenic Mice

(2009) Miriam Matamales et al.   PLoS One

A chemical-genetic approach to study G protein regulation of β cell function in vivo

(2009) Jean-Marc Guettier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inversion of Dopamine Responses in Striatal Medium Spiny Neurons and Involuntary Movements

(2008) L. Liang et al.   JOURNAL OF NEUROSCIENCE

Genome-wide approaches to studying chromatin modifications

(2008) Dustin E. Schones et al.   NATURE REVIEWS GENETICS