Article
Medicine, General & Internal
Robert J. Gil, Adam Kern, Tomasz Pawlowski, Jacek Bil
Summary: This paper summarizes the clinical results of using the BiOSS LIM C stent in the treatment of coronary bifurcations. The study found that the implantation of this stent can reduce the rate of cardiac death, myocardial infarction, and clinically driven target lesion revascularization within 12 months.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Minsu Kim, Albert Youngwoo Jang, Joonpyo Lee, Jeongduk Seo, Yong Hoon Shin, Pyung Chun Oh, Soon Yong Suh, Kyounghoon Lee, Woong Chol Kang, Seung-Hwan Han
Summary: This study compared the clinical outcomes of drug-eluting balloon (DEB) angioplasty and drug-eluting stent (DES) implantation in DES in-stent restenosis (ISR) lesions. The results showed that there was no significant difference in target lesion revascularization between the DEB and DES groups during the 7-year follow-up period. However, the DEB group had better safety outcomes, with lower rates of myocardial infarction and target lesion thrombosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kalpa De Silva, Matthew E. Li Kam Wa, Tim Wells, Abdul Mozid, Andrew Ladwiniec, Brian G. Hynes, Ashish Kotecha, Karim Ratib, Sinjini Biswas, Nicolas Amabile, Pierre Deharo, Margaret Mcentagart, James C. Spratt, Franck Digne, Meadhbh Hogg, Jonathan A. Mailey, Simon J. Walsh, Sundeep S. Kalra
Summary: This study reports the short- to medium-term clinical outcomes of using the Synergy Megatron (TM) everolimus-eluting stent for the treatment of coronary artery disease in a registry conducted at European centers. The results show favorable clinical outcomes at 30 days and 1 year.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Masato Nakamura, Kazushige Kadota, Yoshihisa Nakagawa, Kengo Tanabe, Yoshiaki Ito, Tetsuya Amano, Yuichiro Maekawa, Akihiko Takahashi, Nobuo Shiode, Yoritaka Otsuka, Tomohiro Kawasaki, Yutaka Hikichi, Junya Shite, Ken Kozuma, Raisuke Iijima, Yoshitaka Murakami
Summary: This randomized comparison study showed that ultrathin-strut drug-eluting stents were noninferior to thin-strut drug-eluting stents in terms of target lesion failure at 1 year, indicating that differences in strut thickness among DES have little impact on clinical outcomes when implanted with intravascular imaging guidance.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Yong Zhu, Kesen Liu, Xiangyun Kong, Jing Nan, Ang Gao, Yan Liu, Hongya Han, Hong Li, Huagang Zhu, Jianwei Zhang, Yingxin Zhao
Summary: This meta-analysis assessed the angiographic and clinical outcomes of DES vs. DCB for patients with DES-ISR, and found that repeat DES implantation was associated with a significant reduction in TLR compared with DCB. Subgroup analysis showed DCB was inferior to NG-DES/EES in TLR, while EES was associated with better angiographic outcomes compared to PES. Overall, treatment with DES, especially NG-DES/EES, could reduce the risk of TLR significantly compared to DCB.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Daimy M. M. Dillen, Pieter Jan Vlaar, Amy J. E. Vermeer, Valeria Paradies, Jan-Peter van Kuijk, Maarten A. Vink, Rohit M. Oemrawsingh, Sjoerd H. Hofma, Michael Magro, Wouter S. Remkes, Bart J. G. L. de Smet, Johannes B. van Rees, Samer Somi, Jonathan Halim, Frederik M. Zimmermann, Inge F. Wijnbergen, Jan G. P. Tijssen, Pim A. L. Tonino, Koen Teeuwen
Summary: The Hybrid DEB study is a prospective, multicenter, randomized controlled trial comparing the efficacy of a hybrid DEB approach with a stepwise provisional two-stent strategy in patients with true bifurcation lesions.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yuchao Zhang, Zheng Wu, Shaoping Wang, Tong Liu, Jinghua Liu
Summary: The study aimed to evaluate the long-term clinical outcomes of drug-eluting stent (DES) and paclitaxel-coated balloon (PCB) angioplasty for in-stent chronic total occlusion (IS-CTO) patients. The results showed that DES and PCB angioplasty had similar long-term outcomes, but both had a high rate of long-term major adverse cardiac events (MACEs).
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Yusuke Watanabe, Satoru Mitomo, Toru Naganuma, Hiroyoshi Kawamoto, Kensuke Takagi, Alaide Chieffo, Mauro Carlino, Matteo Montorfano, Sunao Nakamura, Antonio Colombo
Summary: Clinical outcomes were significantly improved with current generation drug eluting stents (cDES) compared to early generation drug eluting stents (eDES) in patients with unprotected distal left main disease (ULMD) treated with double stent strategy (DSS), mainly due to reduction in target lesion revascularization (TLR) at the ostium of left circumflex artery (LCX).
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Takuya Tsujimura, Osamu Iida, Mitsuyoshi Takahara, Yoshimitsu Soga, Terutoshi Yamaoka, Masahiko Fujihara, Daizo Kawasaki, Shigeo Ichihashi, Amane Kozuki, Shinsuke Nanto, Yasushi Sakata, Toshiaki Mano
Summary: This study investigated the impact of IVUS on 1-year clinical outcomes after FP-DES implantation in patients with symptomatic peripheral artery disease. The study found that there was no significant difference in 1-year restenosis risk between the IVUS group and the non-IVUS group, but the incidence of aneurysmal degeneration was significantly higher in the IVUS group.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Kyoung-Woo Seo, Hyoung-Mo Yang, Junghan Yoon, Hyo-Soo Kim, Kiyuk Chang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Seung-Hwan Lee, Sung Gyun Ahn, Young Jin Youn, Jun-Won Lee, Bon-Kwon Koo, Kyung Woo Park, Han-Mo Yang, Jung-Kyu Han, Wook-Sung Chung, Hun-Jun Park, Byung-Hee Hwang, Eun-Ho Choo, Gyu-Chul Oh, Seung-Jea Tahk
Summary: The study evaluated the 5-year clinical outcomes of the Genoss DES, a Korean-made sirolimus-eluting coronary stent with abluminal biodegradable polymer, and found comparable rates of major adverse cardiac events with the Promus Element stent. The results confirm the reliability and effectiveness of the Genoss DES stent.
Article
Cardiac & Cardiovascular Systems
J. J. Coughlan, Alp Aytekin, Tobias Koch, Jens Wiebe, Tobias Lenz, Salvatore Cassese, Michael Joner, Tobias Koppara, Erion Xhepa, Tareq Ibrahim, Massimiliano Fusaro, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner
Summary: This study found that DES overlap is associated with an increased risk of adverse clinical events post PCI, including higher rates of myocardial infarction and target lesion revascularization.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Pharmacology & Pharmacy
Mangesh Sane, Vikas Dighe, Rucha Patil, Puthusserickal A. Hassan, Santosh Gawali, Vandana Patravale
Summary: Localized drug delivery with sustained elution characteristics from nanocarrier coated stents is a viable therapeutic approach to address concerns related to coronary stent therapy. A Sirolimus and Bivalirudin releasing nanoparticles (NPs) coated stent was fabricated for concurrent mitigation of vascular restenosis and acute stent thrombosis, showing superior anti-proliferative activity and higher cellular uptake in human coronary artery smooth muscle cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Pier Pasquale Leone, Manaf Assafin, Andrea Scotti, Maday Gonzalez, Andrea Mignatti, Kathryn Dawson, Judah Rauch, Asma Khaliq, Dimitrios Bliagos, Azeem Latib
Summary: Onyx Frontier is the latest generation drug-eluting stent designed for the treatment of coronary artery disease, with exceptional crossing profile and deliverability. Its refinements compared to previous versions make it ideal for a diverse spectrum of clinical and anatomical scenarios, particularly in high bleeding risk patients and complex coronary lesions.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Engineering, Multidisciplinary
Maciej Kozlik, Jan Harpula, Piotr J. Chuchra, Magdalena Nowak, Wojciech Wojakowski, Pawel Gasior
Summary: Drug-eluting stents (DES) have shown superior efficacy compared to bare metal stents and balloon angioplasty, and are now widely used in percutaneous revascularization procedures. The constant development of DES includes improvements in the stent platform design, materials used, coating techniques, and antiproliferative agents. Understanding the impact of different aspects of stents on clinical outcomes is crucial, given the vast number of available DES platforms. This review discusses the current status of coronary stents and the influence of stent material, strut design, and coating techniques on cardiovascular outcomes.
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jung-Joon Cha, Young-Hoon Jeong, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Hyung Joon Loo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yup Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Do-Sun Lim, Byeong-Keuk Kim
Summary: The long-term prognostic implications of platelet reactivity after percutaneous coronary intervention (PCI) are important. High PRU is significantly associated with the occurrence of major adverse cardiac and cerebrovascular events (MACCE), all-cause death, and net adverse clinical events (NACE).
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Zahra Raisi-Estabragh, Ofer Kobo, Phillip Freeman, Steffen E. Petersen, Louis Kolman, Robert J. H. Miller, Ariel Roguin, Harriette G. C. Van Spall, Jacqueline Vuong, Eric H. Yang, Mamas A. Mamas
Summary: This study reports disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. Ischaemic heart disease was the most common cardiovascular cause of death across all cancer types, followed by cerebrovascular disease and hypertensive diseases. Differential cardiovascular mortality risk was observed based on cancer site and demographics.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Review
Cardiac & Cardiovascular Systems
Ahmed El-Medany, Vanessa Kandoole, Nicholas Lonsdale, Gemina Doolub, Ioannis Felekos
Summary: This review examines the increased risk of coronary stent thrombosis in patients with SARS-CoV-2 infection and discusses the mechanisms, patient factors, and treatments that may influence this risk. The use of antiplatelet and anticoagulation therapies, such as ticagrelor and enoxaparin, may help reduce the severity and likelihood of in-stent thrombosis in COVID-19. Future optimization of thrombotic therapy may involve point-of-care platelet inhibition testing and inflammation-modifying therapies. Large-scale randomized trials with long-term follow-up are needed to further explore the intersection of COVID-19 and stent optimization, as well as the reduction of stent thrombosis after drug-eluting stent (DES) implantation.
CURRENT CARDIOLOGY REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Nuccia Morici, Simone Frea, Maurizio Bertaina, Alice Sacco, Elena Corrada, Carlotta Sorini Dini, Martina Briani, Michele Tedeschi, Francesco Saia, Costanza Colombo, Matteo Rota, Fabrizio Oliva, Mario Iannaccone, Gaetano M. De Ferrari, Alessandro Sionis, Navin K. Kapur, Guido Tavazzi, Federico Pappalardo
Summary: This study explores the association between the updated SCAI stages classification and in-hospital mortality, showing that the SCAI stages can better predict the risk of in-hospital mortality within 24 hours after admission. Therefore, for patients with cardiogenic shock, treatment escalation should be determined based on the SCAI stages within 24 hours after admission.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Ofer Kobo, Dmitry Abramov, Marat Fudim, Garima Sharma, Vijay Bang, Ashish Deshpande, Rishi K. Wadhera, Mamas A. Mamas
Summary: Cardiovascular mortality increased by 4.6% in the United States in 2020 compared to 2019, with the highest increases observed among adults under 55 and Black and Hispanic populations. There was an increase in deaths from ischaemic heart disease, hypertensive disease, and cerebrovascular disease, but a decline in heart failure mortality.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Mario Iannaccone, Luca Franchin, Filippo Russo, Giulia Botti, Davide Castellano, Matteo Montorfano, Giacomo Boccuzzi, Mamas A. Mamas, Alaide Chieffo
Summary: This meta-analysis examines the 30-day mortality of intermediate-to-high risk pulmonary embolism (PE) across different treatment strategies. The findings suggest that medical management alone has a high mortality rate, while an interventional approach may be associated with a lower 30-day mortality rate and a good safety profile.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Fabrizio D'Ascenzo, Francesco Bruno, Mario Iannaccone, Giulia Testa, Ovidio De Filippo, Giuseppe Giannino, Gian Paolo Caviglia, Charles N. Bernstein, Gaetano Maria De Ferrari, Elisabetta Bugianesi, Angelo Armandi, Davide Giuseppe Ribaldone
Summary: This study systematically reviewed the published literature on the risk of myocardial infarction (MI) in inflammatory bowel disease (IBD) patients and found that despite a lower prevalence of classic risk factors for MI, both Crohn's disease (CD) and ulcerative colitis (UC) patients are at increased risk of MI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Salvatore Colangelo, Francesco Colombo, Mario Iannaccone, Giacomo Giovanni Boccuzzi, Kambis Mashayekhi
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Health Care Sciences & Services
Mario Iannaccone, Luca Franchin, Francesco Burzotta, Giulia Botti, Vittorio Pazzanese, Carlo Briguori, Carlo Trani, Tommaso Piva, Federico De Marco, Giulia Masiero, Maurizio Di Biasi, Paolo Pagnotta, Gavino Casu, Anna Mara Scandroglio, Giuseppe Tarantini, Alaide Chieffo
Summary: This study investigated the prognostic impact of LVEF recovery in patients with CS and HR PCI supported with pLVADs. The results showed that in CS patients, significant LVEF recovery was associated with a lower rate of MACE at 1 year, while LVEF recovery was not associated with MACE in HR PCI patients. However, complete revascularisation showed a significant protective effect on MACE in HR PCI patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Grigorios Tsigkas, Angeliki Vakka, Anastasios Apostolos, Eleni Bousoula, Nikolaos Vythoulkas-Biotis, Eleni-Evangelia Koufou, Georgios Vasilagkos, Ioannis Tsiafoutis, Michalis Hamilos, Adel Aminian, Periklis Davlouros
Summary: Cardiovascular events in cancer patients can be caused by various factors, including risk factors, cancer itself, and anticancer therapy. Administering dual antiplatelet therapy (DAPT) to cancer patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) is a challenge to cardiologists. This review aims to explore the optimal antiplatelet therapy and duration of DAPT in order to reduce ischemic and bleeding risk in this high-risk population.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Erick Sanchez-Jimenez, Rami Abu Fanne, Yaniv Levi, Majdi Saada, Ofer Kobo, Ariel Roguin
Summary: Despite effective epicardial coronary recanalization, mechanical complications after acute myocardial infarction (AMI) are associated with high mortality, especially in cardiogenic shock patients. The use of mechanical circulatory support has increased in patients with cardiogenic shock and mechanical complications, but evidence is scarce and most studies exclude patients with mechanical complications.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maurizio Bertaina, Nuccia Morici, Simone Frea, Laura Garatti, Martina Briani, Carlotta Sorini, Luca Villanova, Elena Corrada, Alice Sacco, Marco Moltrasio, Amelia Ravera, Michele Tedeschi, Letizia Bertoldi, Maddalena Lettino, Francesco Saia, Anna Corsini, Rita Camporotondo, Costanza Natalia Julia Colombo, Stephanie Bertolin, Matteo Rota, Fabrizio Oliva, Mario Iannaccone, Serafina Valente, Matteo Pagnesi, Marco Metra, Alessandro Sionis, Marco Marini, Gaetano Maria De Ferrari, Navin K. Kapur, Federico Pappalardo, Guido Tavazzi
Summary: The present analysis compares the clinical features, in-hospital course, and management of cardiogenic shock complicating acutely decompensated heart failure (ADHF-CS) with that complicating acute myocardial infarction (AMI-CS). ADHF-CS patients have a higher prevalence of end-organ and biventricular dysfunction at presentation, longer hospital length of stay, and a higher need for heart replacement therapies compared to AMI-CS patients. In-hospital mortality is similar between the two etiologies. The findings suggest the need for new management protocols focused on the etiology of cardiogenic shock.
Meeting Abstract
Cardiac & Cardiovascular Systems
Michael Kleiner Shochat, Jameel Mohsen, Elias Hellou, Ofer Kobo, Simcha Meisel
JOURNAL OF CARDIAC FAILURE
(2023)
Letter
Urology & Nephrology
Dmitry Abramov, Ofer Kobo, Simon Davies, Roy O. Mathew, Harriette G. C. Van Spall, Mamas A. Mamas
JOURNAL OF NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Zahra Raisi-Estabragh, Ofer Kobo, Teresa Lopez-Fernandez, Husam Abdel Qadir, Nicholas W. S. Chew, Wojtek Wojakowski, Abhishek Abhishek, Robert J. H. Miller, Mamas A. Mamas
Summary: This study examined social disparities in cardiovascular mortality of people with and without cancer in the US population between 1999 and 2019. It found that cardiovascular mortality rate was higher in men, rural settings, and Black or African American races. Over time, there was a decline in cardiovascular mortality rate, with a greater reduction in those with cancer. Sex, race, and ethnic disparities reduced in the cancer cohort, but urban-rural disparities increased.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2023)