Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
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Title
Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
Authors
Keywords
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Journal
Cardiovascular Toxicology
Volume 23, Issue 11-12, Pages 364-376
Publisher
Springer Science and Business Media LLC
Online
2023-10-03
DOI
10.1007/s12012-023-09809-2
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- (2022) Yi Chen et al. PLoS One
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- (2021) Yingchao Ye et al. ANESTHESIA AND ANALGESIA
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- Anthracycline-induced cardiotoxicity: A multicenter randomised trial comparing two strategies for guiding prevention with enalapril: The International CardioOncology Society-one trial
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- (2018) Lisha Zhao et al. Redox Biology
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