PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness

The ILEI/LIFR complex induces EMT via the Akt and ERK pathways in renal interstitial fibrosis

(2022) Jieqing Zhou et al.   Journal of Translational Medicine

The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights

(2022) Sushanta Halder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness

(2021) Ulrike Schmidt et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma

(2021) Liangping Yuan et al.   Molecular Oncology

HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer

(2021) Miranda E. Clements et al.   ONCOGENE

Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity

(2021) Bidyut K Mohanty et al.   Life Science Alliance

TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis

(2021) Simon Grelet et al.   Life Science Alliance

Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR–Hippo–YAP pathway

(2020) Shi‐Bo Bian et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

STAT3 and GR cooperate to drive gene expression and growth of basal-like triple-negative breast cancer

(2020) Megan E Conway et al.   CANCER RESEARCH

Chronic stress promotes EMT-mediated metastasis through activation of STAT3 signaling pathway by miR-337-3p in breast cancer

(2020) Peixin Du et al.   Cell Death & Disease

STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis

(2020) Wei-Hsin Lin et al.   ONCOGENE

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis

(2019) Alec N. Woosley et al.   ONCOGENE

MEST induces Twist-1-mediated EMT through STAT3 activation in breast cancers

(2019) Min Soo Kim et al.   CELL DEATH AND DIFFERENTIATION

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

(2019) Jiang-Jiang Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

(2019) Yu Shi et al.   NATURE

Phosphorylation of LIFR promotes prostate cancer progression by activating the AKT pathway

(2019) Jialiang Shao et al.   CANCER LETTERS

Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell–like Properties in Osteosarcoma

(2019) Bing Lu et al.   MOLECULAR CANCER RESEARCH

TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1

(2018) Breege V. Howley et al.   CYTOKINE

The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer

(2018) Katherine Hughes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR520c blocks EMT progression of human breast cancer cells by repressing STAT3

(2017) Nian Wang et al.   ONCOLOGY REPORTS

Leukemia Inhibitory Factor Promotes Aggressiveness of Chordoma

(2017) Sukru Gulluoglu et al.   ONCOLOGY RESEARCH

Interleukin-6 Family Cytokines

(2017) Stefan Rose-John   Cold Spring Harbor Perspectives in Biology

Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer

(2016) Hanlin Zeng et al.   CANCER CELL

Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein

(2016) Shanshan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Identification and characterization of an hnRNP E1 translational silencing motif

(2016) Andrew S. Brown et al.   NUCLEIC ACIDS RESEARCH

Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis

(2016) Fang Liu et al.   ONCOLOGY REPORTS

Genomic regulation of invasion by STAT3 in triple negative breast cancer

(2016) Joy M. McDaniel et al.   Oncotarget

LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway

(2015) Qin Luo et al.   CARCINOGENESIS

Poly r(C) Binding Protein-1 is Central to Maintenance of Cancer Stem Cells in Prostate Cancer Cells

(2015) Qi Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1

(2015) Z.-Z. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells

(2015) B V Howley et al.   ONCOGENE

Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation

(2015) D Zhao et al.   ONCOGENE

High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma

(2015) Hongwei Guo et al.   Oncotarget

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway

(2015) Xiaoyan Li et al.   Oncotarget

Twist Modulates Breast Cancer Stem Cells by Transcriptional Regulation of CD24 Expression

(2015) Farhad Vesuna et al.   NEOPLASIA

STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion

(2013) Kyung Hwa Cho et al.   CANCER LETTERS

Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

(2013) A. Jacob et al.   JOURNAL OF CELL SCIENCE

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

Stat3 Is Required to Maintain the Full Differentiation Potential of Mammary Stem Cells and the Proliferative Potential of Mammary Luminal Progenitors

(2012) Anna D. Staniszewska et al.   PLoS One

Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step

(2011) George S. Hussey et al.   MOLECULAR CELL

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase

(2010) Haihe Wang et al.   CANCER CELL

Twist-ing cell fate: Mechanistic insights into the role of twist in lineage specification/differentiation and tumorigenesis

(2010) D. Cakouros et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI

(2010) Arindam Chaudhury et al.   NATURE CELL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Phosphoregulation of Twist1 Provides a Mechanism of Cell Fate Control

(2008) Anthony Firulli et al.   CURRENT MEDICINAL CHEMISTRY

Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function

(2008) George Z. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH