4.7 Article

A binding-induced sutured toehold activation for controllable DNA strand displacement reactions

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 14, Pages 2903-2906

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08816f

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Funding

  1. National Natural Science Foundation of China [21175081, 21175082, 21375078, 21475077]

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A novel toehold activation strategy was developed based on hairpin-reconfiguration which was initiated by the interaction between the hairpin and different environmental stimuli (Hg2+ or ATP). Through variation of the concentration of environmental stimuli, it allowed the fine control of the DNA strand displacement rates almost 2 orders of magnitude.

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