Article
Immunology
Karen Krukowski, Amber Nolan, McKenna Becker, Katherine Picard, Nathalie Vernoux, Elma S. Frias, Xi Feng, Marie-Eve Tremblay, Susanna Rosi
Summary: The study revealed that one week after brain injury, microglia exhibit increased phagocytic activity, synaptic engulfment, and neuronal contact, which may contribute to cognitive deficits. By utilizing state-of-the-art techniques, novel microglia-mediated mechanisms that impact neuronal function after TBI were uncovered.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Health Care Sciences & Services
Melissa Brunner, Rachael Rietdijk, Leanne Togher
Summary: The importance of social media skills training for acquired brain injury (ABI) rehabilitation was examined in this study. It was found that there is a limited availability of training resources to support ABI patients in safely using social media. The key recommendations include interactive and practical training, as well as the incorporation of web-based resources to support ABI patients.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Hang Zhou, Libin Hu, Jianru Li, Wu Ruan, Yang Cao, Jianfeng Zhuang, Hangzhe Xu, Yucong Peng, Zhongyuan Zhang, Chaoran Xu, Qian Yu, Yin Li, Zhangqi Dou, Junwen Hu, Xinyan Wu, Xiaobo Yu, Chi Gu, Shenglong Cao, Feng Yan, Gao Chen
Summary: The study demonstrates the role of AXL in transforming astrocytes into a phagocytic phenotype after TBI through the AXL/STAT1/ABCA1 pathway, which helps limit neuroinflammation and improve neurological impairments. The findings provide a potential therapeutic target for TBI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Emma -Jane Mallas, Nikos Gorgoraptis, Sophie Dautricourt, Yoni Pertzov, Gregory Scott, David J. Sharp
Summary: Associative binding is disrupted during post-traumatic amnesia (PTA) following traumatic brain injury (TBI). This disruption is caused by pathological slowing of brain activity, leading to misbinding in working memory. The study found that PTA patients showed abnormalities in working memory function and made more misbinding errors than controls. Slow-wave activity and increased low-frequency power were associated with binding impairment in working memory. Connectivity changes in TBI did not contribute to binding impairment. Overall, these findings highlight the importance of associative binding in memory function and its disruption in PTA following TBI.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Katherine Musacchio Schafer, Emma Wilson, Thomas Joiner
Summary: Suicide is a widespread public health concern, with traumatic brain injuries (TBIs) and lack of social integration identified as risk factors. This cross-sectional study of 1469 military Veterans found that TBI was negatively associated with social integration and positively with suicidality. Social integration was also negatively associated with suicidality. The study suggests that lack of social integration may promote suicidality in the context of TBI and highlights the potential use of social integration as an intervention for suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Fangfang Wu, Renkan Zhang, Weiyang Meng, Lei Liu, Yingdan Tang, Leilei Lu, Leilei Xia, Hongyu Zhang, Zhiguo Feng, Daqing Chen
Summary: This study found that PDGF treatment can inhibit pyroptosis and improve functional recovery after traumatic brain injury. Additionally, autophagy and ER stress play important roles in pyroptosis after TBI, and PDGF can modulate these processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhengtao Gu, Li Li, Qin Li, Hongping Tan, Zhimin Zou, Xueyong Chen, Zichen Zhang, Yijun Zhou, Danian Wei, Chengyong Liu, Qiaobing Huang, Marc Maegele, Daozhang Cai, Mingguang Huang
Summary: Studies have shown that Polydatin (PD) has a protective effect on severe traumatic brain injury-induced acute lung injury (sTBI-ALI), reducing lung damage, promoting vascular permeability recovery, alleviating oxidative stress response and inflammatory cytokine release, and attenuating damage by inhibiting S100B-mediated NETs formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chen-Mei Chen, Pei-Yu Gung, Yen-Chun Ho, Candra D. D. Hamdin, Shaw-Fang Yet
Summary: This study found that probucol can improve functional recovery and cognitive impairment after traumatic brain injury (TBI) by promoting neuroregeneration and neuronal remodeling. In addition, probucol exerts its neuroregenerative effects by increasing the expression of BDNF and activation of TrkB. Therefore, probucol may be a promising new drug for the treatment of TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Psychology, Multidisciplinary
Alice Bodart, Sandra Invernizzi, Laurent Lefebvre, Mandy Rossignol
Summary: While disturbed EDA responses were frequently reported in patients with TBI, other measures did not consistently indicate an impairment in PR. These discrepancies could be due to the lesion pattern resulting from TBI, methodological differences concerning the measurements and their standardization, and the characteristics of the patients. Proposed methodological recommendations aim to improve inter-study comparisons and standardization in physiological data analysis. Future research should converge towards a common methodology to enhance consistency in physiological measurements.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuhua Chen, Kai Gong, Quanhua Xu, Jiao Meng, Tianlin Long, Cuicui Chang, Zhanxiang Wang, Wei Liu
Summary: The study evaluated the effects of PGAM5 on neuronal injury and mitochondrial dysfunction in traumatic brain injury (TBI) models, showing that PGAM5 plays a critical role in TBI progression via Drp1 activation-mediated mitochondrial dysfunction.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Albrecht Froehlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knoll, Maria Cristina Morganti-Kossmann, Hilmar Bading, Francesco Roselli
Summary: This study explores the effects of buffering neuronal nuclear calcium signals in the context of TBI, revealing that it leads to a significant increase in reactive microglial recruitment, accompanied by synaptic loss and reduced whisking activity.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Engineering, Biomedical
Duo Sun, Kaijun Liu, Yang Li, Tian Xie, Mi Zhang, Yu Liu, Haipeng Tong, Yu Guo, Qianhui Zhang, Heng Liu, Jingqin Fang, Xiao Chen
Summary: This study reports the development of intrinsically bioactive multifunctional nanocomposites (AMEC) for targeted theranostics in traumatic brain injury (TBI). AMEC, engineered by loading the neuroprotective agent curcumin on angiopep-2 functionalized and manganese doped eumelanin-like nanoparticles, effectively alleviates neuroinflammation, protects blood-brain barrier integrity, and improves cognition in TBI mice models. The mechanisms of action involve alleviation of oxidative stress, inhibition of neuroinflammation, and promotion of neuronal regeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Psychology, Clinical
Vicki Anderson, Stephen J. C. Hearps, Cathy Catroppa, Miriam H. Beauchamp, Nicholas P. Ryan
Summary: This study investigated the different trajectories of social recovery and the influencing factors in children with traumatic brain injury (TBI) through long-term observation. The results showed that social recovery was linked to intact family and parent function, pre-injury adaptive abilities, post-injury cognition, and social participation. Factors related to social impairment included poor pre- and post-injury adaptive abilities, increased behavioral concerns, and deteriorated parent health and family function.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Mathematical
Kaitlin Lord, Sarah Brown-Schmidt
Summary: Spoken language is interpreted incrementally, leading to temporary ambiguity. Listeners retain both referenced and non-referenced items in memory. This temporary uncertainty enhances memory for items in the referential context.
PSYCHONOMIC BULLETIN & REVIEW
(2022)