Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
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Title
Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
Authors
Keywords
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Journal
BMC Medicine
Volume 21, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-10-31
DOI
10.1186/s12916-023-03117-w
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Note: Only part of the references are listed.- Induced pluripotent stem cell–derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury
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- (2022) Ning Shi et al. IMMUNOLOGIC RESEARCH
- When healing turns into killing – the pathophysiology of pancreatic and hepatic fibrosis
- (2022) Pawel E. Ferdek et al. JOURNAL OF PHYSIOLOGY-LONDON
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- (2022) Alina Scridon et al. Pharmaceutics
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- (2022) Chen-Hung Lee et al. BIOMATERIALS
- Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites
- (2022) Agnieszka A. Kusiak et al. Cell Death & Disease
- Inducible Pluripotent Stem Cell-Derived Small Extracellular Vesicles Rejuvenate Senescent Blood–Brain Barrier to Protect against Ischemic Stroke in Aged Mice
- (2022) Qing Li et al. ACS Nano
- The Global Burden of Cardiovascular Diseases and Risk
- (2022) Muthiah Vaduganathan et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions
- (2021) Jun-Yong Wu et al. DRUG DELIVERY
- Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates
- (2021) Qingju Li et al. Science Translational Medicine
- Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles
- (2021) André Cronemberger Andrade et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Examining the evidence for extracellular RNA function in mammals
- (2021) Hannah N. Gruner et al. NATURE REVIEWS GENETICS
- Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies
- (2021) Mengrui Liu et al. ADVANCED DRUG DELIVERY REVIEWS
- Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice
- (2021) Jonas Gregorius et al. BASIC RESEARCH IN CARDIOLOGY
- Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker
- (2021) Fernanda G. Kugeratski et al. NATURE CELL BIOLOGY
- Extracellular vesicles as a next-generation drug delivery platform
- (2021) Inge Katrin Herrmann et al. Nature Nanotechnology
- Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles
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- Extracellular Vesicles in Organ Fibrosis: Mechanisms, Therapies, and Diagnostics
- (2021) David R. Brigstock Cells
- Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
- (2021) Rosanne E. Veerman et al. Journal of Extracellular Vesicles
- Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities
- (2021) Bethany Claridge et al. Frontiers in Cell and Developmental Biology
- Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism
- (2021) Kinga Nit et al. Journal of Personalized Medicine
- Exosomes derived from induced pluripotent stem cells suppresses M2-type macrophages during pulmonary fibrosis via miR-302a-3p/TET1 axis
- (2021) Yan Zhou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma
- (2021) Milena Paw et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway
- (2021) Lin Zhang et al. Cell Death & Disease
- How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
- (2020) Sajad Yaghoubi et al. IUBMB LIFE
- Targeting the Renin-Angiotensin-Aldosterone System in Fibrosis
- (2020) Mohammad AlQudah et al. MATRIX BIOLOGY
- Native and bioengineered extracellular vesicles for cardiovascular therapeutics
- (2020) Ricardo Cerqueira de Abreu et al. Nature Reviews Cardiology
- Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis
- (2020) Qiang Wu et al. Cell Death & Disease
- Extracellular Vesicles as Therapeutic Agents for Cardiac Fibrosis
- (2020) Russell G. Rogers et al. Frontiers in Physiology
- Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment
- (2020) Dawid Wnuk et al. Scientific Reports
- The Global Burden of Cardiovascular Diseases and Risks
- (2020) Gregory A. Roth et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Fibrosis: from mechanisms to medicines
- (2020) Neil C. Henderson et al. NATURE
- Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine
- (2019) Cristina Mas-Bargues et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cardiac fibrosis – A short review of causes and therapeutic strategies
- (2019) Svenja Hinderer et al. ADVANCED DRUG DELIVERY REVIEWS
- Advances in epigenetics link genetics to the environment and disease
- (2019) Giacomo Cavalli et al. NATURE
- Targeting cardiac fibrosis with engineered T cells
- (2019) Haig Aghajanian et al. NATURE
- miRDB: an online database for prediction of functional microRNA targets
- (2019) Yuhao Chen et al. NUCLEIC ACIDS RESEARCH
- MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis
- (2019) Valerio Licursi et al. BMC BIOINFORMATICS
- Myocardial fibrosis: why image, how to image and clinical implications
- (2019) Rong Bing et al. HEART
- RNA Therapeutics in Cardiovascular Disease
- (2018) Tina Lucas et al. CIRCULATION RESEARCH
- Angiotensin II–Induced End-Organ Damage in Mice Is Attenuated by Human Exosomes and by an Exosomal Y RNA FragmentNovelty and Significance
- (2018) Linda Cambier et al. HYPERTENSION
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- (2018) Guillaume van Niel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Fibroblast-to-myofibroblast transition in bronchial asthma
- (2018) Marta Michalik et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Cardiac fibrosis: new insights into the pathogenesis
- (2018) Zhen-Guo Ma et al. International Journal of Biological Sciences
- Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization
- (2018) Milena Paw et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2018) Zhenqiang Sun et al. Molecular Cancer
- Lipofuscin-mediated photodynamic stress induces adverse changes in nanomechanical properties of retinal pigment epithelium cells
- (2018) Anna Wiktor et al. Scientific Reports
- The nanomechanical role of melanin granules in the retinal pigment epithelium
- (2017) Michal Sarna et al. Nanomedicine-Nanotechnology Biology and Medicine
- Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation
- (2017) Emma A. Mol et al. Nanomedicine-Nanotechnology Biology and Medicine
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- (2017) Zhiyun Wei et al. Nature Communications
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- (2017) Marta Adamiak et al. CIRCULATION RESEARCH
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- (2016) Hirak Biswas et al. PLoS One
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- (2015) Jens Schuster et al. Cellular Reprogramming
- Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes
- (2015) Douglas D. Taylor et al. METHODS
- DIANA-miRPath v3.0: deciphering microRNA function with experimental support
- (2015) Ioannis S. Vlachos et al. NUCLEIC ACIDS RESEARCH
- Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior
- (2015) Sylwia Bobis-Wozowicz et al. STEM CELLS
- Predicting effective microRNA target sites in mammalian mRNAs
- (2015) Vikram Agarwal et al. eLife
- Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts
- (2015) Michal Sarna et al. PLoS One
- Quantitative and stoichiometric analysis of the microRNA content of exosomes
- (2014) J. R. Chevillet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AtomicJ: An open source software for analysis of force curves
- (2014) Paweł Hermanowicz et al. REVIEW OF SCIENTIFIC INSTRUMENTS
- Triterpene saponosides from Lysimachia ciliata differentially attenuate invasive potential of prostate cancer cells
- (2013) Paulina Koczurkiewicz et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Stem cell transplantation as a therapy for cardiac fibrosis
- (2012) Mohammad T Elnakish et al. JOURNAL OF PATHOLOGY
- Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
- (2012) Maria Francesca Baietti et al. NATURE CELL BIOLOGY
- Targeting the TGFβ signalling pathway in disease
- (2012) Rosemary J. Akhurst et al. NATURE REVIEWS DRUG DISCOVERY
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