Discovery of new non-covalent and covalent inhibitors targeting SARS-CoV-2 papain-like protease and main protease

Advances in the Omicron variant development

(2022) Antonio Vitiello et al.   JOURNAL OF INTERNAL MEDICINE

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease

(2022) Haozhou Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Real-world effectiveness of homologous and heterologous BNT162b2, CoronaVac, and AZD1222 booster vaccination against Delta and Omicron SARS-CoV-2 infection

(2022) Jing Lian Suah et al.   Emerging Microbes & Infections

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

(2021) Yingjun Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

(2021) Jerzy Osipiuk et al.   Nature Communications

Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

(2021) Ewelina Weglarz-Tomczak et al.   Scientific Reports

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

(2021) Stephanie Patchett et al.   Cell Reports

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

(2021) Chunlong Ma et al.   ACS Central Science

Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors

(2021) Sarah Huff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

(2021) Deeksha Munnur et al.   NATURE IMMUNOLOGY

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro

(2021) Caleb D. Swaim et al.   iScience

Understanding evolution of SARS‐CoV‐2: a perspective from analysis of genetic diversity of RdRp gene

(2020) Sunitha M. Kasibhatla et al.   JOURNAL OF MEDICAL VIROLOGY

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography

(2020) Daniel W. Kneller et al.   Nature Communications

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Ebselen, a new candidate therapeutic against SARS-CoV-2

(2020) C.V. Haritha et al.   International Journal of Surgery

A protein structure-guided covalent scaffold selectively targets the B1 and B2 subclass metallo-β-lactamases

(2018) Cheng Chen et al.   CHEMICAL COMMUNICATIONS

Target discovery of ebselen with a biotinylated probe

(2018) Zhenzhen Chen et al.   CHEMICAL COMMUNICATIONS

Ebsulfur as a potent scaffold for inhibition and labelling of New Delhi metallo-β-lactamase-1 in vitro and in vivo

(2018) Jianpeng Su et al.   BIOORGANIC CHEMISTRY

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

(2016) Nicholas C.K. Valerie et al.   CANCER RESEARCH

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)

(2015) Jiachi Chiou et al.   CHEMICAL COMMUNICATIONS

An accurate proteomic quantification method: Fluorescence labeling absolute quantification (FLAQ) using multidimensional liquid chromatography and tandem mass spectrometry

(2012) Junyan Liu et al.   PROTEOMICS