Article
Engineering, Biomedical
Sarah R. Brady, Simone B. Gohsman, Keven Sepulveda, Jessica D. Weaver
Summary: Hydrogel injection molding is a useful biofabrication method for rapidly generating complex cell-laden hydrogel structures in tissue engineering applications. This study explores the feasibility of using synthetic PEG-based hydrogels functionalized with strain promoted azide-alkyne cycloaddition click chemistry groups for injection molding. Mechanical properties, such as gelation time and successful generation of complex geometries, as well as the binding and retention of adhesive ligand RGD and cell viability and function, are evaluated. The results demonstrate the potential utility of injection molding synthetic PEG-based hydrogels in tissue engineering applications and biomanufacturing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Polymer Science
Elena Iulia Oprita, Andreea Iosageanu, Oana Craciunescu
Summary: This paper reviews the complex structure of osteochondral tissue, the importance of icariin in osteochondral regeneration, and the recent development of hydrogels and scaffolds enriched with icariin. Icariin has chondrogenic and osteogenic effects, making it a promising alternative to growth factors. The use of icariin as a therapeutic approach in regenerative medicine is low-cost and has potential.
Article
Engineering, Biomedical
Siming Zhang, Gaoran Ge, Yi Qin, Wenhao Li, Jiale Dong, Jiawei Mei, Ruixiang Ma, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu, Weiwei Zhang, Dechun Geng
Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.
MATERIALS TODAY BIO
(2023)
Review
Engineering, Biomedical
Mohammad Hadi Norahan, Sara Cristina Pedroza-Gonz, Monica Gabriela Sanchez-Salazar, Mario Moises Alvarez, Grissel Trujillo de Santiago
Summary: Chronic wounds have become a major problem in healthcare systems, leading to death worldwide. Engineering wound dressings with hydrogels can significantly improve healing time, reduce infections, and lower costs. Hydrogels provide a protective barrier, mimic the extracellular matrix, and create a moist environment. Different fabrication methods and properties of hydrogels have been extensively studied for wound healing applications, including the use of additives to enhance tissue regeneration. Hydrogel engineering offers smart solutions for effective wound healing, with capabilities such as inhibiting bacterial growth, promoting re-epithelialization, and improving tissue functionality.
BIOACTIVE MATERIALS
(2023)
Review
Polymer Science
Md Mahamudul Hasan Rumon, Anwarul Azim Akib, Fahmida Sultana, Md Moniruzzaman, Mahruba Sultana Niloy, Md Salman Shakil, Chanchal Kumar Roy
Summary: Self-healing hydrogels are promising materials in biomedical applications with controllable responses to external stimuli. The suitable combination of materials and challenges in development are crucial for their advancement.
Article
Chemistry, Applied
Xin Liu, Shuai Liu, Rong Yang, Penghui Wang, Wenjie Zhang, Xiaoyan Tan, Yanhan Ren, Bo Chi
Summary: A gradient hydrogel scaffold was designed based on the structure and composition distribution in biological cartilage tissue, showing excellent physical properties and cell compatibility. The scaffold can mimic the function of natural cartilage, making it a potential option for cartilage tissue engineering.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Nahideh Asadi, Hamidreza Pazoki-Toroudi, Azizeh Rahmani Del Bakhshayesh, Abolfazl Akbarzadeh, Soodabeh Davaran, Nasim Annabi
Summary: Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix and ability to provide a moist environment. However, lack of multifunctionality and low mechanical properties may limit their ability to support skin tissue regeneration. Incorporating various biomaterials and nanostructures is an emerging approach to develop multifunctional hydrogels for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Chunyan Dou, Zheng Li, Ying Luo, Jixian Gong, Qiujin Li, Jianfei Zhang, Qingsong Zhang, Changsheng Qiao
Summary: A hybrid double-network (DN) full biological hydrogel was successfully constructed by introducing a physically cross-linked gelatin (GEL) network in a covalently cross-linked poly (gamma-glutamic acid) (gamma-PGA) network. The gamma-PGA-GEL DN hydrogel exhibited excellent mechanical properties and biocompatibility, with ultra-high compression performance and satisfactory tensile performance. It also showed better recovery and healing properties compared to the gamma-PGA single-network (SN) hydrogel. In addition, the gamma-PGA-GEL DN hydrogel had good transparency, swelling, and degradability. In vitro cell experiments demonstrated its benefits in cell adhesion and proliferation. Evaluation on a rat skin defect model showed that the gamma-PGA-GEL DN hydrogel could significantly accelerate wound healing, making it an ideal candidate material for wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Yuanyuan Jiang, Jie Wang, Hui Zhang, Guopu Chen, Yuanjin Zhao
Summary: In this research, a novel bionic hydrogel was developed by crosslinking natural platelet and alginate through covalent amidation for wound healing. The platelet-derived hydrogel exhibited excellent biocompatibility and blood compatibility, and could be customized for different wound environments. Silver nanoparticles could also be loaded into the hydrogel, providing superior anti-infective properties. The bio-inspired platelet hydrogel showed potential values in clinical applications by promoting hemostasis, preventing bacterial proliferation, and facilitating tissue healing.
Article
Engineering, Biomedical
Jason L. Guo, Yu Seon Kim, Gerry L. Koons, Johnny Lam, Adam M. Navara, Sergio Barrios, Virginia Y. Xie, Emma Watson, Brandon T. Smith, Hannah A. Pearce, Elysse A. Orchard, Jeroen J. J. P. van den Beucken, John A. Jansen, Mark E. Wong, Antonios G. Mikos
Summary: The study developed a bilayered hydrogel system that click functionalizes cartilage-and bone-specific biochemical cues, successfully promoting the development of both cartilage and bone tissues in vivo.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Jing Li, Qinhua Chen, Jin Wang, Xiaoyan Pan, Jie Zhang
Summary: Hydrogels are hydrophilic and water-soluble polymer systems with a three-dimensional network structure, known for their high moisturizing properties, good biocompatibility, and controlled biodegradability. They have been widely used in wound dressing and other fields. Recent years have seen an increase in the use of antibacterial gel dressings for wound healing, with a focus on the application of environmentally responsive intelligent hydrogel delivery systems. The future development prospects and challenges of hydrogel wound dressings are also discussed in this article.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
X. Ma, R. Yang, P. Wang, S. Liu, H. Xu, Z. Ye, B. Chi
Summary: A facile strategy based on dynamic chemistry was presented to prepare injectable hydrogels using hyaluronic acid and poly(gamma-glutamic acid), enabling efficient stem cell delivery. The hydrogels showed stable structure, rapid self-healing ability, and injectability with dual dynamic networks. Remarkably, the hydrogels promoted stem cell viability, proliferation, and cartilage regeneration in preclinical models.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Yiwen Xi, Prashant Kumar Sharma, Hans Jan Kaper, Chang-Hwan Choi
Summary: The study investigated the tribological properties of micropored pHEMA under physiologically relevant conditions, finding that it significantly reduced frictional energy dissipation at relatively high loads and sliding speeds. This was attributed to the greater amount and retentivity of the interfacial fluid supported by the free water squeezed out of micropores with smaller dimensions under higher load and sliding speed.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Xu Yang, Baolong Wang, Di Sha, Yonggang Liu, Jiuduo Xu, Kai Shi, Cong Yu, Xiangling Ji
Summary: The injectable and antibacterial hydrogels based on c-poly (L-lysine)-modified poly (vinyl alcohol)/chitosan/silver complexes displayed excellent bactericidal properties, biocompatibility, and accelerated wound healing effects.
Article
Polymer Science
Hailin Wu, Jing Chen, Jiyoung Kim, Peizhi Zhu, Jiadeng Zhu, Qiang Gao, Chunxia Gao
Summary: In this study, a transparent poly (gamma-glutamic acid) modified polyvinyl alcohol (gamma-PGA/PVA) hydrogel with excellent mechanical properties was prepared by immersion method. The hydrogel showed high tensile strength, toughness, torsion, knotting, and puncture resistance, as well as good conductivity and sensitivity to external strain. The cytocompatibility of the hydrogel with MC3T3-E1 cells was also demonstrated.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)