Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy

Unraveling the therapeutic mechanisms of dichloroacetic acid in lung cancer through integrated multi-omics approaches: metabolomics and transcriptomics

(2023) Malong Feng et al.   Frontiers in Genetics

Emerging Intrinsic Therapeutic Targets for Metastatic Breast Cancer

(2023) Jiawei Li et al.   Biology-Basel

Novel tumor therapy strategies targeting endoplasmic reticulum-mitochondria signal pathways

(2023) Hongzheng Wu et al.   AGEING RESEARCH REVIEWS

Molecular mechanisms and clinical implications of the gold drug auranofin

(2023) Shuying Shen et al.   COORDINATION CHEMISTRY REVIEWS

Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

(2023) Feng Ye et al.   Molecular Cancer

Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function

(2022) E. Sandra Chocron et al.   Communications Biology

The Thioredoxin System of Mammalian Cells and Its Modulators

(2022) Aseel Ali Hasan et al.   Biomedicines

Cytotoxic derivatives of dichloroacetic acid and some metal complexes

(2022) Mohammad Hossain et al.   ARCHIV DER PHARMAZIE

Darinaparsin: First Approval

(2022) James E. Frampton   DRUGS

Thioredoxin Reductase Inhibition for Cancer Therapy

(2021) Radosveta Gencheva et al.   Annual Review of Pharmacology and Toxicology

Reactive oxygen species in cancer: Current findings and future directions

(2021) Hajime Nakamura et al.   CANCER SCIENCE

Thioredoxin reductase is a major regulator of metabolism in leukemia cells

(2021) Sheelarani Karunanithi et al.   ONCOGENE

Anticancer drug resistance: An update and perspective

(2021) Ruth Nussinov et al.   DRUG RESISTANCE UPDATES

The multifaceted role of reactive oxygen species in tumorigenesis

(2020) Anuradha Kirtonia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

(2020) Morana Jaganjac et al.   Antioxidants

Overview of thioredoxin system and targeted therapies for acute leukemia

(2019) Weiling Xie et al.   MITOCHONDRION

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

(2019) Yuning Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors

(2018) Valeria Scalcon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

(2018) Qing-Yu Zhang et al.   Frontiers in Pharmacology

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

(2018) Zhe Zhang et al.   Redox Biology

Mitochondrial ROS control of cancer

(2017) María del Pilar Sosa Idelchik et al.   SEMINARS IN CANCER BIOLOGY

Targeting the Thioredoxin System for Cancer Therapy

(2017) Junmin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

p-Azidophenylarsenoxide: An Arsenical “Bait” for the In Situ Capture and Identification of Cellular Arsenic-Binding Proteins

(2016) Xiaowen Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The thioredoxin system in breast cancer cell invasion and migration

(2016) Maneet Bhatia et al.   Redox Biology

Reactive oxygen species in redox cancer therapy

(2015) Lingying Tong et al.   CANCER LETTERS

Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

(2015) Ammad Ahmad Farooqi et al.   TUMOR BIOLOGY

4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells

(2015) Lakshmi Galam et al.   Oncotarget

Dithiaarsanes Induce Oxidative Stress-Mediated Apoptosis in HL-60 Cells by Selectively Targeting Thioredoxin Reductase

(2014) Yaping Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectivity in ROS-Induced Peptide Backbone Bond Cleavage

(2014) Hannah M. Stringfellow et al.   JOURNAL OF PHYSICAL CHEMISTRY A

High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance

(2014) Huijun Qin et al.   FEBS Open Bio

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

(2013) Laura Horsley et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

(2013) X Peng et al.   Cell Death & Disease

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

(2011) Caroline Haglund et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Small molecule inhibitors of mammalian thioredoxin reductase

(2011) Wenqing Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710

(2010) B. L. Powell et al.   BLOOD

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

(2010) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

(2009) Eng-Hui Chew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer

(2007) Terumasa Noike et al.   HUMAN PATHOLOGY