UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models

The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation

(2022) Taigo Horiguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective

(2020) Marlies Corine Ludikhuize et al.   ANTIOXIDANTS & REDOX SIGNALING

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

(2019) Alberto Rissone et al.   Disease Models & Mechanisms

Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors

(2018) Koichi Oshima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells

(2017) Xiaoli Li et al.   Oncotarget

Reticular dysgenesis–associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress

(2015) Alberto Rissone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages

(2015) E Six et al.   Cell Death & Disease

Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro

(2015) Yali Zhong et al.   Oncotarget

Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation

(2015) Chengcheng Li et al.   Cell and Bioscience

Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage

(2014) L. R. Souza et al.   Cancer Prevention Research

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase

(2013) Marjan Amiri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Haematopoietic stem cell transplantation for SCID patients: where do we stand?

(2012) Marina Cavazzana-Calvo et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Novel Serum-Free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells via Mesodermal Progenitors

(2011) Akira Niwa et al.   PLoS One

The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes

(2010) Christakis Panayiotou et al.   BIOCHEMICAL JOURNAL

Adenylate Kinase and AMP Signaling Networks: Metabolic Monitoring, Signal Communication and Body Energy Sensing

(2009) Petras Dzeja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

(2008) Chantal Lagresle-Peyrou et al.   NATURE GENETICS

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2

(2008) Ulrich Pannicke et al.   NATURE GENETICS