Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Junya Hata, Yuki Harigane, Kanako Matsuoka, Hidenori Akaihata, Kei Yaginuma, Satoru Meguro, Seiji Hoshi, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima
Summary: Benign prostatic hyperplasia (BPH) is a chronic proliferative disease mainly characterized by stromal proliferation. Although aging and androgen have been considered risk factors, recent studies suggest the involvement of androgen-independent factors, such as inflammation, in BPH development. In this study, whole-genome gene expression analysis using a stromal-dominant BPH rat model revealed activated immune response-related pathways and complement classical pathways. Moreover, the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. Understanding the role of androgen-independent factors, like immune responses, contributes to unraveling the pathogenesis of BPH and may lead to new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Agriculture, Multidisciplinary
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An
Summary: Purple corn extract (PCE) has ameliorative effects on benign prostatic hyperplasia (BPH) by reducing androgen receptor (AR) expression and inhibiting the PI3K/AKT signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xueni Wang, Junjie Zhu, Huimin Yan, Mengyao Shi, Qiaoqi Zheng, Yu Wang, Yan Zhu, Lin Miao, Xiumei Gao
Summary: Kaempferol has been identified as a natural compound that inhibits tumor development in androgenic related prostate cancer and suppresses testosterone-induced benign prostatic hyperplasia (BPH) via modulation of the androgen receptor function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Tiziana Genovese, Marika Cordaro, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Livia Interdonato, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri
Summary: The study revealed that ultra-micronized um-PEA/Baic can reduce prostate weight and DHT production in BPH-induced rats, while modulating apoptotic and inflammatory pathways as well as oxidative stress.
Review
Biochemistry & Molecular Biology
Weronika Ratajczak, Michal Lubkowski, Anna Lubkowska
Summary: This review article discusses the role of heat shock proteins (HSPs) in prostate diseases and their potential as therapeutic targets. HSPs are overexpressed in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), and play roles in maintaining cell homeostasis, protein folding and repair, as well as immune response and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kai-Yen Tsai, Deng-Chyang Wu, Wen-Jeng Wu, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Hsiang-Ying Lee
Summary: This study investigates the potential relationship between human microbiota and prostatic disease by analyzing stool and urine samples from patients. The results suggest that the microbiota composition in urine samples is different among different patient populations, indicating a potential link between microbiota and prostatic disease.
Review
Biology
Che-Hsueh Yang, Yen-Chuan Ou, Chi-Chien Lin, Yi-Sheng Lin, Min-Che Tung, Chia-Cheng Yu, Jen-Tai Lin, Chen-Yueh Wen
Summary: Phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, shows promising effects in treating BPH and PCa, based on animal and in-vitro studies. Further research is needed regarding its safety and effective dosages in human clinical trials.
Article
Oncology
Ritaparna Ahmed, Leyder Elena Lozano, Amandine Anastasio, Sebastien Lofek, Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, Sylvain Nguyen, Florence Dartiguenave, Sonia-Cristina Rodrigues-Dias, Valerie Cesson, Massimo Valerio, Beat Roth, Lana Elias Kandalaft, Irina Redchenko, Adrian Vivian Sinton Hill, Alexandre Harari, Pedro Romero, Laurent Derre, Selena Vigano
Summary: Lymphocytes expanded from BPH tissue samples can recognize tumor antigens and autologous tissue independently from the presence of tumor lesions. These findings support the connection between BPH and prostate cancer and may lead to personalized preventive vaccination strategies for patients with BPH.
Article
Geriatrics & Gerontology
Sha-sha Wang, Kai Li, Zhiwei Liu, Shukang Gui, Nian Liu, Xiangyun Liu
Summary: The study demonstrated that aerobic exercise could slow fat mass gain, improve BPH-related indicators, reduce blood lipid levels, and alleviate BPH symptoms in obese mice by regulating the AR/androgen/PI3K/AKT signaling pathway.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Pharmacology & Pharmacy
Eman M. Elbaz, Alshaymaa Darwish, Amany M. Gad, Amina A. S. Abdel Rahman, Maheera H. Safwat
Summary: This study aimed to investigate the therapeutic effect of Canagliflozin, a selective SGLT2 inhibitor, on BPH in elderly males. The results demonstrated that Cana can impede BPH progression by modulating miR-128b/EGFR/EGF and JAK2/STAT3 pathways and downregulating AR, cyclin D1, and PCNA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Yuqiu Ge, Bin Xu, Hongzhou Cai, Wentao Jing, Qiong Ouyang, Qinbo Yuan, Xu Li, Yuanming Fan, Yang Shen, Qianqian Shi, Qiangdong Wang, Li Cui, Xiaojian Yin, Gaoxiang Ma
Summary: In this study, ORM2 was identified as a complementary biomarker to PSA in distinguishing between PCa and BPH, showing superior predictive accuracy compared to PSA alone.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Integrative & Complementary Medicine
Tian Fang, Ze-sheng Xue, Jia-xuan Li, Jia-kuan Liu, Di Wu, Mei-qian Li, Yu-ting Song, Shi-feng Yun, Jun Yan
Summary: The extract of Rauwolfia vomitoria significantly reduced prostate weight and proliferation markers in BPH rats, while also decreasing the expression levels of androgen receptor and its associated proteins. Compared to the reference drug, R. vomitoria extract did not significantly affect sperm count, suggesting it may be a promising therapeutic agent for BPH with milder side effects.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Immunology
Saade Abdalkareem Jasim, Hamzah H. Kzar, Mohammed Haider Hamad, Irfan Ahmad, Moaed E. Al-Gazally, Shukhrat Ziyadullaev, R. Sivaraman, Mohammed Abed Jawad, Ali Thaeer Hammid, Khulood H. Oudaha, Sajad Karampoor, Rasoul Mirzaei
Summary: Oxysterols are cholesterol metabolites with various biological functions, including their involvement in cancer development and immunological suppression. Specifically, 27-hydroxycholesterol (27-HC) may act as an estrogen and promote the growth of estrogen receptor (ER) positive breast cancer cells. However, the precise role of 27-HC in cancer promotion and progression is still debatable, and more research is needed to uncover the exact function of these molecules.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Infectious Diseases
Qiao-Jing Tong, Kimberly D. P. Hammer, Erika M. Johnson, Milagros Zegarra, Michihiko Goto, Tze Shien Lo
INFECTION AND DRUG RESISTANCE
(2018)
Review
Oncology
Megan Meyer, Mahesh Seetharam
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Liye Wang, Kwang Bog Cho, Yan Li, Gabriel Tao, Zuoxu Xie, Bin Guo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Caleb J. Scheckel, Megan Meyer, Jeffrey Alan Betcher, Aref Al-Kali, James Foran, Jeanne Palmer
Article
Biochemistry & Molecular Biology
Liye Wang, Shuang Zhou, Bin Guo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Xiang Gao, Jingwen Liu, Kwang Bog Cho, Samanthreddy Kedika, Bin Guo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Orthopedics
Megan M. Sullivan, Michael M. Pham, Lisa A. Marks, Fawad Aslam
Summary: In treating persistent monoarthritis in rheumatoid arthritis, intra-articular methotrexate was not found to be clinically beneficial. Intra-articular TNFi therapy appears to have comparable efficacy to intra-articular steroids, although the optimal dose and frequency of injections remain unknown.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Satya Prakash Shukla, Kwang Bog Cho, Vineeta Rustagi, Xiang Gao, Xinping Fu, Shaun Xiaoliu Zhang, Bin Guo, D. Gomika Udugamasooriya
Summary: The study identified two ACE2-binding peptoid compounds that effectively block the entry of SARS-CoV-2 into human cells. These compounds also showed efficacy against a mutant virus and were found to be safe without reducing ACE2 expression or enzyme activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Benzion Blech, Megan Meyer, Brent Goodman, Molly Knox, Fawad Aslam, Alessandra Schmitt, Marie Grill
Summary: This case report presents a unique case of GPA with autonomic failure and pituitary dysfunction, showing objective findings of autonomic dysfunction that were responsive to immunosuppressive therapy.
Review
Rheumatology
Megan M. Meyer, Lisa A. Marks, Fawad Aslam
Summary: Through a literature review, it was found that monosodium urate (MSU) crystals are more stable in terms of time, temperature, and preservatives, while calcium pyrophosphate (CPP) crystals tend to deteriorate over time. It is recommended to perform synovial fluid crystal examination within 24-48 hours, with options of storage at room temperature without preservatives, or refrigeration and EDTA preservation.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Health Policy & Services
Andrea L. Huseth-Zosel, Kimberly D. Hammer
JOURNAL OF COMMUNITY HEALTH
(2018)
Review
Biochemistry & Molecular Biology
Gurdeep Marwarha, Shaneabbas Raza, Kimberly Hammer, Othman Ghribi
CHEMISTRY AND PHYSICS OF LIPIDS
(2017)
Article
Oncology
Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly D. P. Hammer, Bin Guo, Othman Ghribi
CANCER CELL INTERNATIONAL
(2017)