Article
Oncology
Xiaodong Guo, Zhengjun Hu, Shu Rong, Guoqun Xie, Gang Nie, Xuan Liu, Gang Jin
Summary: This study identified differences in intestinal flora and metabolites between resectable and unresectable PDAC patients, providing valuable insights for early diagnosis and prognosis.
Article
Biochemistry & Molecular Biology
Vartika Bisht, Katrina Nash, Yuanwei Xu, Prasoon Agarwal, Sofie Bosch, Georgios V. Gkoutos, Animesh Acharjee
Summary: This study utilized public omics data sets to investigate potential associations between microbiome, metabolome, bulk transcriptomics and single cell RNA sequencing datasets, identifying multiple potential interactions and key genes involved in colorectal cancer pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Yingxu Zeng, Baichuan Deng, Zixin Kang, Pedro Araujo, Svein Are Mjos, Ruina Liu, Jianhui Lin, Tao Yang, Yuangao Qu
Summary: Microplastics (MPs) are a major environmental threat to marine organisms and ecosystems on a global scale. This study focused on the impacts of MPs accumulation in Litopenaeus vannamei, showing that MPs accumulate in various organs and have negative effects on growth, swimming behavior, and swimming performance of the shrimp. MPs exposure also led to oxidative stress, lipid peroxidation, and hepatopancreatic damage, which worsened with increasing MPs concentrations. Metabolomics analysis revealed alterations in metabolic profiles and disrupted glycolysis, lipolysis, and amino acid metabolism pathways in the hepatopancreas of L. vannamei. This research enhances our understanding of the sublethal impacts and toxic modes of action of MPs in L. vannamei.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Sheng Wu, Hsin-Yi Wu, Pin-Hsuan Wang, Ting-Yu Chen, Kuan-Ru Chen, Chih-Wei Chang, Dong-En Lee, Bo-Heng Lin, William Chih-Wei Chang, Pao-Chi Liao
Summary: Lung cancer is a major cause of cancer-related death worldwide, and research is needed to dissect its pathogenic mechanisms and discover specific biomarkers. LCMD is the first database to provide information on lung cancer-related metabolites, aiming to promote the discovery of biomarkers for lung cancer.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yongpeng Shi, Jiande Li, Ji Wang, Hanwen Cao, Huanbing Tian, FeiFei Yu, Lan Gao
Summary: This study investigated the mechanism of COL-induced diarrhea by exposing mice to COL. The results showed that COL exposure disrupted intestinal metabolic homeostasis, resulting in accumulation or depletion of various metabolites. Certain core metabolites were found to be closely related to COL-induced diarrhea and could be used as biomarkers. Changes in metabolic pathways and abnormal bile secretion were identified as important factors in COL-induced diarrhea.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Agronomy
Carlos J. Garcia, Veronica Alacid, Francisco A. Tomas-Barberan, Carlos Garcia, Pedro Palazon
Summary: The control and development of plant growth promoters is essential for the agronomy industry. This study used untargeted metabolomics to investigate the metabolites responsible for the biostimulant effects of three bacteria. The results revealed several metabolic pathways, including the pentose phosphate pathway, tryptophan metabolism, zeatin biosynthesis, vitamin B6 metabolism, and amino acid metabolism, that are related to bacteria biostimulant activity. Additionally, 14 metabolites were identified as biomarkers of the biostimulant capabilities.
Article
Environmental Sciences
QiuLan Zhang, Xin Liu, MengTing Gao, Xin Li, YiFei Wang, YueYue Chang, XueMeng Zhang, ZongLi Huo, Li Zhang, JinJun Shan, Feng Zhang, BaoLi Zhu, WeiFeng Yao
Summary: This study analyzed the serum metabolic alterations in workers from chemical factories exposed to glyphosate, and assessed the potential health risks at the molecular level. The results showed that glyphosate exposure caused significant changes in metabolic pathways, indicating potential adverse health effects and the development of various diseases. Four potential biomarkers related to glyphosate exposure were identified. These findings provide new insights into the mechanisms and health risks associated with glyphosate exposure.
Article
Veterinary Sciences
Luis Guillermo Gonzalez-Arostegui, Camila Peres Rubio, Ivana Rubic, Renata Baric Rafaj, Jelena Gotic, Jose Joaquin Ceron, Asta Tvarijonaviciute, Vladimir Mrljak, Alberto Munoz-Prieto
Summary: The objective of this study was to evaluate the changes in the salivary metabolic profile in dogs with hypothyroidism. The results showed that hypothyroidism produces changes in saliva metabolites, and some of these changes may reflect the metabolic alterations in the disease and could serve as potential biomarkers.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne-Thea McGill, Sally D. Poppitt, Karl Fraser
Summary: Untargeted metabolomics of blood samples has been widely used to study metabolic alterations in diseases and identify biomarkers. This study found that the concentration of metabolites in plasma was more reflective of the liver profile than muscle or adipose tissue, highlighting the importance of considering the metabolomic relationship between different tissues and plasma.
Article
Respiratory System
Wen-Wen Wang, Bei Mao, Yang Liu, Shu-Yi Gu, Hai-Wen Lu, Jiu-Wu Bai, Shuo Liang, Jia-Wei Yang, Jian-Xiong Li, Xiao Su, Hai-Yang Hu, Chen Wang, Jin-Fu Xu
Summary: This study utilized a multi-omics approach to identify differences in gut microbiota and metabolic profiles between bronchiectasis patients and healthy volunteers. It revealed the potential of gut microbiota as biomarkers for bronchiectasis.
RESPIRATORY RESEARCH
(2022)
Article
Veterinary Sciences
Elizabeth M. Morris, Susanna E. Kitts-Morgan, Dawn M. Spangler, Ibukun M. Ogunade, Kyle R. McLeod, David L. Harmon
Summary: The study found that supplementation of 4.5 mg CBD/kg BW/d for 3 weeks altered the canine metabolome, affecting metabolites involved in the metabolism of amino acids, glucose, vitamins, etc. Using metabolomics and biomarker analysis, the impact of CBD on canine metabolism has been identified.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Jinyoung Kim, Carola Blaser, Reto Portmann, Rene Badertscher, Corinne Marmonier, Adeline Blot, Jeremie David, Helena Stoffers, Ueli von Ah, Ueli Butikofer, Guy Vergeres, Dominique Dardevet, Sergio Polakof
Summary: The identification and validation of biomarkers of food intake is a promising approach to develop more objective and complementary tools to the traditional dietary assessment methods. This study identified and compared the biomarkers of milk and yogurt intake through metabolomics analysis. The findings suggest that these biomarkers could be used as potential indicators of food intake, and population specificities, such as aging, should be considered in future studies.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Donghai Liang, Jonathan Batross, Nancy Fiedler, Tippawan Prapamontol, Panrapee Suttiwan, Parinya Panuwet, Warangkana Naksen, Brittney O. Baumert, Volha Yakimavets, Youran Tan, Priya D'Souza, Ampica Mangklabruks, Supattra Sittiwang, Kristsanachai Kaewthit, Kanyapak Kohsuwan, Nattawadee Promkam, Sureewan Pingwong, P. Barry Ryan, Dana Boyd Barr
Summary: This study investigated the biological perturbations associated with chlorpyrifos exposure among pregnant women in Thailand. The findings suggest that chlorpyrifos exposure is linked to oxidative stress, cellular damage and repair, and systemic inflammation, which could have adverse health effects on both maternal and child health outcomes, including neurodevelopmental deficits.
ENVIRONMENTAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Shi Qiu, Sifan Guo, Qiang Yang, Yiqiang Xie, Songqi Tang, Aihua Zhang
Summary: Metabolites are interrelated genotypes that can provide clear information about the final phenotype. The high-throughput analysis platform can quickly detect metabolic characteristics from large spectral data, which involves peak data preprocessing, statistical analysis, and functional interpretation. Developing a comprehensive strategy for discovering and verifying bioactive metabolites can provide a large number of new functional biomarkers, revealing their functional changes, and having biological significance for disease diagnosis and prognosis treatment.
FRONTIERS IN CHEMISTRY
(2023)
Article
Microbiology
Qiong Nan, Yan Ye, Yan Tao, Xinyi Jiang, Yinglei Miao, Jie Jia, Jiarong Miao
Summary: Ulcerative colitis (UC) is a complex disease with both genetic and environmental factors involved. In this study, metabolomic and metagenomic profiling of fecal samples from UC mice and KT2-treated mice were conducted. The results showed significant changes in metabolites related to phenylalanine metabolism, histidine metabolism, and bile acid biosynthesis. The fecal microbiome analysis revealed differences in bacterial species associated with the course of UC, and a disease-associated network connecting these bacteria with UC-associated metabolites was identified. This study provides potential evidence for the discovery of biomarkers of UC.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Ryte Rynkeviciene, Julija Simiene, Egle Strainiene, Vaidotas Stankevicius, Jurgita Usinskiene, Edita Miseikyte Kaubriene, Ingrida Meskinyte, Jonas Cicenas, Kestutis Suziedelis
Article
Oncology
Jaroslav Tumas, Inga Baskirova, Tomas Petrenas, Jolita Norkuniene, Kestutis Strupas, Audrius Sileikis
ANTICANCER RESEARCH
(2019)
Article
Oncology
Dalius Kuciauskas, Nadezda Dreize, Marija Ger, Algirdas Kaupinis, Kristijonas Zemaitis, Vaidotas Stankevicius, Kestutis Suziedelis, Jonas Cicenas, Lee M. Graves, Mindaugas Valius
Article
Medicine, General & Internal
Matas Jakubauskas, Raminta Luksaite, Audrius Sileikis, Kestutis Strupas, Tomas Poskus
MEDICINA-LITHUANIA
(2019)
Article
Nutrition & Dietetics
Jaroslav Tumas, Birute Tumiene, Jolita Jurkeviciene, Eugenijus Jasiunas, Audrius Sileikis
CLINICAL NUTRITION
(2020)
Article
Medicine, General & Internal
Jaroslav Tumas, Eugenijus Jasiunas, Kestutis Strupas, Audrius Sileikis
MEDICINA-LITHUANIA
(2020)
Article
Oncology
Egle Zalyte, Veronika Dedonyte, Benediktas Kurlinkus, Audrius Sileikis, Peter Schemmer, Mindaugas Valius
Summary: The newly established pancreatic cancer cell line Capan-26 exhibits unique characteristics such as long cell doubling time, specific marker expression, mutations, and high sensitivity, making it a valuable tool for studying the mechanisms of pancreatic cancer.
ANTICANCER RESEARCH
(2021)
Editorial Material
Oncology
Jonas Cicenas, Asta Raciene
Article
Biology
Benediktas Kurlinkus, Marija Ger, Algirdas Kaupinis, Eugenijus Jasiunas, Mindaugas Valius, Audrius Sileikis
Summary: This study identified CEACAM6 as a promising new biomarker for pancreatic cancer, with significant prognostic value and prediction of chemoresistance properties, enabling the improvement of individualised approaches to patients with this disease.
Article
Oncology
Skaiste Tulyte, Dainius Characiejus, Reda Matuzeviciene, Ausra Janiulioniene, Mantas Radzevicius, Tadas Zvirblis, Audrius Sileikis
Summary: This study evaluated the changes in circulating lymphocytes in patients with pancreatic ductal adenocarcinoma (PDAC) and found significant alterations in cell counts during treatment.
ANTICANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Egle Zalyte, Jonas Cicenas
Summary: Pancreatic cancer is a highly metastatic and therapy-resistant disease. This study explores a novel approach to kill pancreatic cancer cells by combining starvation with ferroptosis induction. The results indicate that the ERK1/2 and JNK signaling pathways, as well as the transition between epithelial and mesenchymal states, mediate sensitivity to ferroptosis in starved pancreatic cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Valerija Mosenko, Saulius Jurevicius, Audrius Sileikis
Summary: Enterocutaneous fistula is an abnormal connection between the gastrointestinal tract and the skin, usually a complication of gastrointestinal surgery. The use of self-expanding metal stents (SEMS) to cover the fistula is a treatment method, but its application in small bowel ECF is still debated.
MEDICINA-LITHUANIA
(2022)
Article
Surgery
Audrius Sileikis, Saulius Jurevicius, Mykolas Butvila, Kestutis Strupas
POLISH JOURNAL OF SURGERY
(2019)
Article
Surgery
Audrius Sileikis, Ruta Zulpaite, Aukse Sileikyte, Martynas Luksta
POLISH JOURNAL OF SURGERY
(2019)
Meeting Abstract
Oncology
S. Tulyte, A. Sileikis, I. Tarnulyte, A. Ranceva, D. Characiejus, R. Matuzeviciene, A. Janiulioniene, T. Zvirblis
ANNALS OF ONCOLOGY
(2019)
