Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine

Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

(2022) Ji Hyun Kim et al.   MEDICINE

A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective

(2022) Suvadeep Mal et al.   DRUG DEVELOPMENT RESEARCH

Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay

(2022) Hye Yun Chae et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Medicinal chemistry insights into non-hydroxamate HDAC6 selective inhibitors

(2022) Faridoon et al.   MEDICINAL CHEMISTRY RESEARCH

Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor

(2020) Sida Shen et al.   ACS Medicinal Chemistry Letters

MeBib Suppressed Methamphetamine Self-Administration Response via Inhibition of BDNF/ERK/CREB Signal Pathway in the Hippocampus

(2020) Buyun Kim et al.   Biomolecules & Therapeutics

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

(2020) Michael Morgen et al.   ChemMedChem

Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications

(2020) Jinling Qin et al.   Anti-Cancer Agents in Medicinal Chemistry

PBN inhibits a detrimental effect of methamphetamine on brain endothelial cells by alleviating the generation of reactive oxygen species

(2020) Jong Su Hwang et al.   ARCHIVES OF PHARMACAL RESEARCH

Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors

(2020) Maurício T. Tavares et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indazole scaffold: a generalist for marketed and clinical drugs

(2020) Yaquan Cao et al.   MEDICINAL CHEMISTRY RESEARCH

Targeting epigenetics for cancer therapy

(2019) Jong Woo Park et al.   ARCHIVES OF PHARMACAL RESEARCH

A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019)

(2019) Sida Shen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Development of Thiazolidinedione-Based HDAC6 Inhibitors to Overcome Methamphetamine Addiction

(2019) Chiranjeev Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aspirin-inspired acetyl-donating HDACs inhibitors

(2018) Jiah Lim et al.   ARCHIVES OF PHARMACAL RESEARCH

Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections

(2018) Yahui Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer’s Disease Phenotypes

(2018) Hsueh-Yun Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

(2018) Sheng-Jun Fan et al.   Cell Death & Disease

It's a complex issue: Emerging connections between epigenetic regulators in drug addiction

(2018) Ethan M Anderson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

(2018) Alan P. Kozikowski et al.   ACS Chemical Neuroscience

Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress

(2018) Youra Kang et al.   Biomolecules & Therapeutics

Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats

(2017) Stephanie M Groman et al.   NEUROPSYCHOPHARMACOLOGY

HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination

(2017) Martin G. Strebl et al.   ACS Central Science

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

(2016) Yang Hai et al.   Nature Chemical Biology

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

(2016) Yasuyuki Miyake et al.   Nature Chemical Biology

Histone deacetylase inhibitors in hematological malignancies and solid tumors

(2015) Pusoon Chun   ARCHIVES OF PHARMACAL RESEARCH

Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

(2015) Sida Shen et al.   ChemMedChem

Epigenetic landscape of amphetamine and methamphetamine addiction in rodents

(2015) Arthur Godino et al.   Epigenetics

Methamphetamine promotes α-tubulin deacetylation in endothelial cells: The protective role of acetyl-l-carnitine

(2015) S. Fernandes et al.   TOXICOLOGY LETTERS

Single and Binge Methamphetamine Administrations Have Different Effects on the Levels of Dopamine D2 Autoreceptor and Dopamine Transporter in Rat Striatum

(2014) Heli Chauhan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum

(2014) Oluwaseyi Omonijo et al.   NEUROTOXICOLOGY

Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability

(2013) Jeanine Jochems et al.   NEUROPSYCHOPHARMACOLOGY

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial

(2012) Toshihiko Doi et al.   International Journal of Clinical Oncology

Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/Hypoacetylation in the Rat Nucleus Accumbens

(2012) Tracey A. Martin et al.   PLoS One

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Histone deacetylase inhibitors that target tubulin

(2009) Jörg Schemies et al.   CANCER LETTERS

Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition

(2009) Lionel Host et al.   JOURNAL OF PSYCHOPHARMACOLOGY