Synthesis and biological evaluation of novel salicylidene uracils: Cytotoxic activity on human cancer cell lines and inhibitory action on enzymatic activity

Structural characterization and biological evaluation of uracil-appended benzylic amines as acetylcholinesterase and carbonic anhydrase I and II inhibitors

(2023) Zafer Bulut et al.   JOURNAL OF MOLECULAR STRUCTURE

Relationship between the antiproliferative properties of Cu(II) complexes with the Schiff base derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil and the redox status mediated by antioxidant defense systems on glioma tumoral cells

(2020) Nuria A. Illán-Cabeza et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthetic, characterization and cytotoxic studies of ruthenium complexes with Schiff bases encompassing biologically relevant moieties

(2020) Sanam Maikoo et al.   POLYHEDRON

Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders

(2020) Deepthi Ramesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies

(2019) Huseyin Cavdar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one’s aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties

(2019) Musa Özil et al.   BIOORGANIC CHEMISTRY

Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects

(2018) Haroon Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects on estrogen-dependent and triple negative breast cancer cells growth of Ni(II), Zn(II) and Cd(II) complexes with the Schiff base derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil explored through the renin-angiotensin system (RAS)-regulating aminopeptidases

(2018) Nuria A. Illán-Cabeza et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

(2017) Di-Zao Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitory properties of some uracil derivatives

(2017) Emir Alper Türkoğlu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors

(2016) Raed Yaseen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides

(2015) Denis A. Babkov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives

(2015) Semra Işık et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives

(2015) Murat Güney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications

(2015) Aleksandra Pałasz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiophene aldehyde-diamino uracil Schiff base: A novel fluorescent probe for detection and quantification of cupric, silver and ferric ions

(2015) Hassan H. Hammud et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX

(2014) Virginija Dudutienė et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

Quantitative comparison of protein dynamics in live cells and in vitro by in-cell 19F-NMR

(2013) Yousuke Takaoka et al.   CHEMICAL COMMUNICATIONS

A potential antitumor agent, (6-amino-1-methyl-5-nitrosouracilato-N3)-triphenylphosphine-gold(I): Structural studies and in vivo biological effects against experimental glioma

(2013) Nuria A. Illán-Cabeza et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site

(2011) Serdar Durdagi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives

(2011) Halis T. Balaydın et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI

(2011) Deniz Ekinci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters

(2011) Hüseyin Çavdar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue

(2011) D M Kasozi et al.   REDOX REPORT

Isosorbide-2-benzyl Carbamate-5-salicylate, A Peripheral Anionic Site Binding Subnanomolar Selective Butyrylcholinesterase Inhibitor

(2010) Ciaran G. Carolan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrimidine based highly sensitive fluorescent receptor for Al3+ showing dual signalling mechanism

(2010) K. K. Upadhyay et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glutathione: A key player in autoimmunity

(2009) Carlo Perricone et al.   AUTOIMMUNITY REVIEWS

Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer

(2009) William B. Parker   CHEMICAL REVIEWS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY