Design, synthesis, biological evaluation, and in silico studies of quinoxaline derivatives as potent p38α MAPK inhibitors

Analgesic and anti-inflammatory activity of quinoxaline derivatives: Design synthesis and characterization

(2023) Geethavani Meka et al.   Results in Chemistry

Hydrazide-Hydrazones as Small Molecule Tropomyosin Receptor Kinase A (TRKA) Inhibitors: Synthesis, Anticancer Activities, In Silico ADME and Molecular Docking Studies

(2022) Mohammad Sayed Alam et al.   Medicinal Chemistry

Structural modelling and in silico pharmacology of β-carboline alkaloids as potent 5-HT1A receptor antagonists and reuptake inhibitors

(2022) Yusuf Oloruntoyin Ayipo et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents

(2022) Himanshu Singh et al.   MEDICINAL CHEMISTRY RESEARCH

A Comprehensive Study to Unleash the Putative Inhibitors of Serotype2 of Dengue Virus: Insights from an In Silico Structure-Based Drug Discovery

(2022) Sajal Kumar Halder et al.   MOLECULAR BIOTECHNOLOGY

Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime- and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors

(2022) Bijo Mathew et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Computational modelling of potential Zn-sensitive non-β-lactam inhibitors of imipenemase-1 (IMP-1)

(2022) Yusuf Oloruntoyin Ayipo et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Phytochemicals from Amberboa ramosa as potential DPP-IV inhibitors for the management of Type-II diabetes mellitus: Inferences from in-silico investigations

(2022) Rakesh Kumar Paul et al.   JOURNAL OF MOLECULAR STRUCTURE

Modeling the anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of (E)-6-chloro-N2-phenyl-N4-(4-Phenyl-5-(Phenyl Diazinyl)-2λ3, 3 λ2- Thiazol-2-yl)-1, 3, 5-Triazine-2,4- Diamine

(2022) Innocent Benjamin et al.   POLYCYCLIC AROMATIC COMPOUNDS

Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico, and molecular docking study

(2022) Sachin Puri et al.   TOXICOLOGY IN VITRO

Unveiling chlorpyrifos mineralizing and tomato plant-growth activities of Enterobacter sp. strain HSTU-ASh6 using biochemical tests, field experiments, genomics, and in silico analyses

(2022) Md. Azizul Haque et al.   Frontiers in Microbiology

Synthesis, docking, and biological investigations of new coumarin-piperazine hybrids as potential antibacterial and anticancer agents

(2022) Kajalben B. Patel et al.   JOURNAL OF MOLECULAR STRUCTURE

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

(2021) Marc Montana et al.   MOLECULES

New 2-amino-pyridinyl-N-acylhydrazones: Synthesis and identification of their mechanism of anti-inflammatory action

(2020) Natalia de Moraes Cordeiro et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis, evaluation and docking of novel pyrazolo pyrimidines as potent p38α MAP kinase inhibitors with improved anti-inflammatory, ulcerogenic and TNF-α inhibitory properties

(2019) Kanagasabai Somakala et al.   BIOORGANIC CHEMISTRY

Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages

(2019) Utsab Debnath et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis, p38α MAP kinase inhibition, anti-inflammatory activity, and molecular docking studies of 1,2,4-triazole-based benzothiazole-2-amines

(2018) Sana Tariq et al.   ARCHIV DER PHARMAZIE

Synthesis, anti-inflammatory, p38α MAP kinase inhibitory activities and molecular docking studies of quinoxaline derivatives containing triazole moiety

(2018) Sana Tariq et al.   BIOORGANIC CHEMISTRY

Quinoxaline: An insight into the recent pharmacological advances

(2018) Sana Tariq et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies

(2018) Sana Tariq et al.   BIOORGANIC CHEMISTRY

Synthesis and Biological Evaluation of 8-Hydroxyquinoline-hydrazones for Anti-HIV-1 and Anticancer Potential

(2018) Purvi Shah et al.   ChemistrySelect

Structure–activity relationship study of anticancer thymidine–quinoxaline conjugates under the low radiance of long wavelength ultraviolet light for photodynamic therapy

(2016) Dejun Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoxaline, its derivatives and applications: A State of the Art review

(2015) Joana A. Pereira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats

(2015) Behnam Ghorbanzadeh et al.   INDIAN JOURNAL OF PHARMACOLOGY

Tyrphostin AG1296, a platelet-derived growth factor receptor inhibitor, induces apoptosis, and reduces viability and migration of PLX4032-resistant melanoma cells

(2015) Li et al.   OncoTargets and Therapy

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

(2013) D. Martin Watterson et al.   PLoS One

Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives

(2013) Kazi Abdus Salam et al.   Biomed Research International

Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6

(2012) Antonio Guirado et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyridinylquinoxalines and Pyridinylpyridopyrazines as Lead Compounds for Novel p38α Mitogen-Activated Protein Kinase Inhibitors

(2010) Pierre Koch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzothiazole based inhibitors of p38α MAP kinase

(2008) Chunjian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region

(2008) Stefan A. Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY