Article
Chemistry, Medicinal
Giti Rahimi, Saeideh Shams, Mohammad Reza Aslani
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive condition in women, associated with hyperlipidemia, insulin resistance, obesity, and chronic low-grade inflammation. Crocin supplementation improves lipid profile, insulin, cardioprotective indices, and has protective effects on inflammatory markers.
PHYTOTHERAPY RESEARCH
(2022)
Article
Anatomy & Morphology
Cemile Merve Seymen, Atiye Seda Yar Saglam, Zubeyir Elmazoglu, Gokce Nur Arik, Gulnur Take Kaplanoglu
Summary: The study investigated the involvement of endometrial IGF-1R/IGF-1/Bcl-2 pathways and the potential regulatory effects of exogenously administered melatonin in PCOS. Results showed that melatonin administration could reverse the morphological changes induced by polycystic ovary induction.
Article
Endocrinology & Metabolism
Anamil M. Khiyami, Tahereh Orouji Jokar, Hussein M. Abdallah, Paul A. Gardner, Georgios A. Zenonos, Aaron K. Styer, Pouneh K. Fazeli
Summary: This study found that the number of chromaffin cells in the white blood cells was significantly increased in patients with pheochromocytoma compared to normal individuals, which may be an important marker of this disease. In addition, the study also found that the number of chromaffin cells in the white blood cells was associated with the level of monoamine oxidase activity in the patients' blood.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Manjunath Ramanjaneya, Ibrahem Abdalhakam, Ilham Bettahi, Milin Bensila, Jayakumar Jerobin, Myint Myint Aye, Meis Alkasem, Thozhukat Sathyapalan, Stephen Lawrence Atkin, Abdul-Badi Abou-Samra
Summary: Exercise can decrease levels of complement-related proteins in control women, but not in women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Larisa Suturina, Natalia Belkova, Ilia Igumnov, Ludmila Lazareva, Irina Danusevich, Iana Nadeliaeva, Leonid Sholokhov, Maria Rashidova, Lilia Belenkaya, Aleksey Belskikh, Eldar Sharifulin, Kseniia Ievleva, Natalia Babaeva, Irina Egorova, Madinabonu Salimova, Mikhail Kuzmin, Daria Tiumentseva, Elizaveta Klimenko, Tuyana Sidorova, Alina Atalyan
Summary: Abnormalities in gut microbiota diversity are important mechanisms in metabolic disorders in polycystic ovarian syndrome (PCOS), but the association between these disorders and PCOS phenotype is controversial. This study aimed to estimate the alpha diversity of gut microbiota in healthy women and PCOS patients based on phenotype. The study participants were recruited in Russia from 2016 to 2019, and alpha diversity indexes were calculated using metasequencing. The results showed a significant decrease in alpha diversity in classic PCOS phenotypes compared to healthy women without PCOS.
Article
Obstetrics & Gynecology
Alexandra L. P. Dietz de Loos, Geranne Jiskoot, Reinier Timman, Annemerle Beerthuizen, Jan J. Busschbach, Joop S. E. Laven
Summary: The study investigated the effects of weight loss interventions on women with polycystic ovary syndrome. Results showed that lifestyle interventions had more profound improvements on PCOS characteristics compared to standard care, and weight loss significantly ameliorated ovulatory dysfunction and hyperandrogenism. It is recommended that a three-component lifestyle intervention aimed at a 5-10% weight loss should be considered for women with PCOS before pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Medicine, Research & Experimental
Lan Wang, Jing Zhou, Hans-Juergen Gober, Wing Ting Leung, Zengshu Huang, Xinyao Pan, Chuyu Li, Na Zhang, Ling Wang
Summary: PCOS is a complex disorder characterized by chronic anovulation and hyperandrogenaemia, with multiple factors, including the intestinal microbiome, influencing its pathogenesis. The gut microbiome may play a role in PCOS progression and phenotypes through various mechanisms, making modulation of the microbiome a potential therapy. Future studies are needed to elucidate the specific role of different microbial genera in PCOS and how the microbiome impacts the disease.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Medicine, General & Internal
Enrico Carmina, Rogerio A. Lobo
Summary: This study investigated the influence of body weight on the various phenotypes of women with Polycystic Ovary Syndrome (PCOS). It revealed that the Rotterdam diagnostic criteria fail to differentiate between obese patients with altered metabolic patterns and lean patients with normal metabolic patterns. A new classification system is needed.
Review
Obstetrics & Gynecology
Fei Guo, Yufan Huang, Taniya Fernando, Yingli Shi
Summary: Impaired endometrial development and receptivity in PCOS patients contribute to lower pregnancy rates and higher miscarriage rates, but are often overlooked in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Zeynep Ece Utkan Korun, Semil Selcen Gocmez, Selenay Furat Rencber, Kuebra Kavram Sarihan, Fatma Ceylan Eraldemir, Deniz Sahin
Summary: This study examined the efficacy of etanercept in alleviating endocrine, metabolic, and vascular dysfunction in a rat model of PCOS. The results showed that etanercept treatment restored hormonal imbalances and vascular function, suggesting potential therapeutic advantages for PCOS patients.
REPRODUCTIVE SCIENCES
(2023)
Review
Obstetrics & Gynecology
Subeka Abraham Gnanadass, Yogamaya Divakar Prabhu, Abilash Valsala Gopalakrishnan
Summary: Inflammatory markers play a significant role in regulating ovarian function, and any disturbances in their levels can lead to ovarian dysfunction. The association between inflammatory markers and PCOS pathogenesis implies that inflammation is one of the most potent risk factors for PCOS.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Lorena Orostica, Isis Astorga, Francisca Plaza-Parrochia, Cristian Poblete, Rodrigo Carvajal, Victor Garcia, Carmen Romero, Margarita Vega
Summary: PCOS is an endocrine/metabolic disorder associated with insulin resistance and obesity. This study found that MTF can improve insulin and adiponectin signaling in endometrial tissues, independent of PCOS. This suggests that MTF may help improve insulin action and reproductive issues in women with obesity/PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sarhang Hasan Azeez, Ismail Bilal Ismail, Suhaila Nafia Darogha
Summary: PCOS is a prevalent and complicated gynecological endocrine disease that affects around 6% to 10% of women of reproductive age. This study focused on Kurdish females with PCOS, analyzing their clinical characteristics, hormone levels, and genetic variations, revealing a positive relationship between IL-6-174GC polymorphism and PCOS, while no association was found for TNF-alpha -308GA.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Malgorzata Kaczkan, Sylwia Czaja-Stolc, Malgorzata Szczuko, Arleta Drozd, Przemyslaw Rutkowski, Alicja Debska-Slizien, Sylwia Malgorzewicz
Summary: The concentration of water-soluble vitamins is often not measured in hemodialysis patients, leading to undiagnosed deficiencies. This study compared the blood concentration of water-soluble vitamins in hemodialysis patients with healthy subjects and assessed the impact of diabetes mellitus on these vitamins. The study found significantly lower levels of vitamin B-1, B-6, and B-12 in the hemodialysis group.
Article
Nutrition & Dietetics
Beata Loniewska, Magda Fraszczyk-Tousty, Piotr Tousty, Karolina Skonieczna-Zydecka, Dominika Maciejewska-Markiewicz, Igor Loniewski
Summary: This study analyzed 456 fecal samples from 86 children to investigate the influence of perinatal factors on the concentrations of fecal short-chain fatty acids (SCFAs) during the first two years of life. The results showed that SCFA concentrations increased until 12 months and then stabilized. Factors such as antibiotic treatment during pregnancy, mode of delivery, feeding formula, and maternal weight gain were found to be associated with changes in SCFA concentrations. Higher SCFA levels were observed in infants born to mothers with normal pre-pregnancy weight and adequate weight gain. Additionally, female infants had higher levels of acetic acid at 2 years old. The study suggests the need for further long-term epidemiological studies in this area.
Article
Chemistry, Multidisciplinary
Katarzyna Janda-Milczarek, Kinga Szymczykowska, Karolina Jakubczyk, Patrycja Kupnicka, Karolina Skonieczna-Zydecka, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Alicja Ligenza, Ewa Stachowska, Bartosz Dalewski
Summary: The study aimed to explore the effect of supplement form (tablet and powder) and cultivation method (organic and conventional) on the mineral content of spirulina supplements. The findings showed that both supplement form and cultivation method had an impact on the mineral content, with powder supplements containing higher amounts of important elements and organic spirulina supplements being a richer dietary source of iron and potassium.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Arleta Drozd, Dariusz Kotlega, Krzysztof Dmytrow, Malgorzata Szczuko
Summary: The main aim of this study was to investigate the impact of cigarette smoking on selected derivatives of arachidonic acid, linoleic acid, DHA, and EPA, which may serve as markers for post-stroke inflammation. The eicosanoid profile was compared between smokers and non-smokers, both with and without gender division. The results revealed that non-smokers had higher levels of the linolenic acid derivative (LA) 9S HODE than smokers. However, when the results were further divided by gender, it was found that non-smoking women had higher levels of this derivative compared to smoking women, while no difference was observed in the group of men. Similarly, the level of the arachidonic acid metabolite LTX A4 differed only in the group of women. Moreover, a number of statistically significant correlations were identified between the analyzed groups, with smokers showing fewer correlations compared to non-smokers. This study highlights the importance of smoking cessation in reducing inflammation mediated by lipid mediators in both genders.
Article
Biochemistry & Molecular Biology
Dominika Maciejewska-Markiewicz, Joanna Kochman, Karolina Jakubczyk, Piotr Bargiel, Zbigniew Szlosser, Ewa Stachowska, Marta Markowska, Anna Bucka, Norbert Czapla, Jan Petriczko, Anna Surowka, Sonia Hertman, Piotr Puchalski, Piotr Prowans
Summary: This study aimed to assess the concentration of vitamin D and its metabolites in patients before thyroidectomy. The results showed that patients undergoing thyroidectomy have a marked vitamin D deficiency, which may affect their subsequent convalescence and prognosis. Therefore, determining vitamin D levels prior to thyroidectomy may be useful for considering supplementation in the clinical management of these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Anna Gudan, Katarzyna Kozlowska-Petriczko, Ewa Wunsch, Tomasz Bodnarczuk, Ewa Stachowska
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid accumulation in the liver. Insulin resistance is common among NAFLD patients. Obesity is a major risk factor for lipid accumulation, but normal-weight individuals can also develop NAFLD. Obesity, with or without NAFLD, is associated with a higher incidence of small intestinal bacterial overgrowth (SIBO), while NAFLD patients also show increased intestinal permeability. SIBO can lead to malabsorption disorders and impair liver function, but more research is needed to understand its impact on liver dysfunction, intestinal barrier integrity, inflammation, endotoxemia, and bacterial translocation.
Review
Nutrition & Dietetics
Karolina Kedzierska-Kapuza, Urszula Szczuko, Hanna Stolinska, Dimitra Rafailia Bakaloudi, Waldemar Wierzba, Malgorzata Szczuko
Summary: This review article examines the benefits and potential risks of supplementing water-soluble vitamins in the treatment of chronic kidney disease (CKD). By reducing oxidative stress and covering the increased demand and losses associated with treatment, water-soluble vitamin supplementation may improve pharmacological responses and the overall clinical condition of patients.
Review
Nutrition & Dietetics
Dominika Jamiol-Milc, Anna Gudan, Karolina Kazmierczak-Siedlecka, Joanna Holowko-Ziolek, Dominika Maciejewska-Markiewicz, Katarzyna Janda-Milczarek, Ewa Stachowska
Summary: The liver plays a crucial role in the metabolism of nutrients and the storage of micronutrients, but chronic liver diseases can lead to nutritional deficiencies and poor prognosis. This review focuses on the dietary therapy for patients with chronic liver diseases, including those eligible for liver transplantation and in the postoperative period.
Article
Nutrition & Dietetics
Malgorzata Szczuko, Natalia Szwec-Nadworna, Joanna Palma, Malgorzata Tomasik, Maciej Zietek
Summary: Inflammation occurs during pregnancy, and the levels of anti-inflammatory resolvins and their precursors vary in different trimesters and in relation to pre-pregnancy weight groups. Overweight or obese women have lower levels of anti-inflammatory resolvins, possibly due to lower intake of omega-3 fatty acids and increased need to alleviate chronic inflammation.
Article
Chemistry, Multidisciplinary
Weronika Jacunska, Wioletta Biel, Robert Witkowicz, Dominika Maciejewska-Markiewicz, Ewa Piatkowska
Summary: A balanced diet is essential for a dog's energy, growth, immunity, and overall health. Customizing the diet based on the dog's age, size, and activity level is crucial. This study evaluated the nutrient content of puppy diets containing EPA and DHA fatty acids. The diets met the protein and fat requirements, but varied in terms of essential fatty acid levels. None of the diets fulfilled the claims for EPA and DHA, and all contained trans fat.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Malgorzata Szczuko, Justyna Golanska, Joanna Palma, Maciej Zietek
Summary: This study analyzed the impact of individual eicosanoid levels on the course of normal pregnancy and the possibility of pathologies such as gestational diabetes and pre-eclampsia. The researchers found a significant correlation between being overweight and having a high BMI before pregnancy, as well as biochemical parameters of lipid and carbohydrate profiles, with the occurrence of pathological conditions in pregnancy. Eicosanoids may be involved in the pathology of pregnancy-associated complications and salicylic acid could be a potential treatment option.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Katarzyna Kotfis, Arleta Wojciechowska, Malgorzata Zimny, Dominika Jamiol-Milc, Aleksandra Szylinska, Sebastian Kwiatkowski, Karolina Kaim, Barbara Dolegowska, Ewa Stachowska, Maciej Zukowski, Maria Pankowiak, Andrzej Torbe, Paul Wischmeyer
Summary: This study compared the effectiveness of oral carbohydrate loading (CHO) with standard fasting in patients undergoing elective cesarean delivery (CD). The results showed that the incidence of vomiting or dry retching within 24 hours after CD was lower in the CHO group compared to the standard fasting group. Additionally, CHO supplementation reduced preoperative feelings of hunger and thirst, enhancing the comfort of pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
