Article
Dentistry, Oral Surgery & Medicine
Joao Luiz Guilherme Neto, Lucas Gabriel Rodrigues Venturini, Ayda Henriques Schneider, Thaise Mayumi Taira, Leticia Fernanda Duf fles Rodrigues, Favio Protasio Veras, Sicilia Rezende Oliveira, Tarcilia Aparecida da Silva, Fernando Queiroz Cunha, Sandra Yasuyo Fukada
Summary: Neutrophil extracellular traps (NETs) play an important role in the pathogenesis of apical periodontitis by regulating local inflammation and osteoclast activity, leading to bone resorption. Depletion of NETs reduces apical lesion size and alveolar bone resorption in mice.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luciano Aparecido Almeida-Junior, Marcio Santos de Carvalho, Lana Kei Yamamoto Almeida, Alice Correa Silva-Sousa, Manoel Damiao Sousa-Neto, Raquel Assed Bezerra Silva, Lea Assed Bezerra Silva, Francisco Wanderley Garcia Paula-Silva
Summary: This study investigated the role of the TNF-a-TNFR1 proinflammatory axis in periapical inflammation and bone resorption. The results showed that TNFR1(-/-) mice exhibited reduced inflammation and bone resorption compared to wild-type mice.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Isabelly Vidal do Nascimento, Maria Imaculada de Queiroz Rodrigues, Pedro Henrique Chaves Isaias, Paulo Goberlanio Barros-Silva, Fabricio Bitu Sousa, Ana Paula Negreiros Nunes Alves, Mario Rogerio Lima Mota
Summary: The study aimed to evaluate the inflammatory response and development of apical periodontitis in rats chronically treated with glucocorticoids. The results showed that glucocorticoid treatment caused an early increase in bone resorption and pulp necrosis, accompanied by alterations in cytokine levels, inflammatory response, and collagen deposition.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Review
Immunology
Xiaoyu Sun, Jike Gao, Xiang Meng, Xiaoxuan Lu, Lei Zhang, Ran Chen
Summary: Macrophages play crucial roles in periodontitis, with different types impacting the immune system and the destruction and repair of periodontal tissues. Polarized M1 and M2 macrophages are involved in inflammatory and anti-inflammatory stages respectively, regulating the progression of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim
Summary: GRP modulates osteoclastogenesis by influencing the differentiation of bone marrow-derived cells, potentially contributing to the pathogenesis of periodontitis. Stimulation by P. gingivalis can enhance crosstalk between epithelial cells and bone marrow-derived cells, leading to increased osteoclast formation.
Article
Immunology
Izabel C. V. de Oliveira, Leonardo V. Galvao-Moreira, Juliana L. Vilela, Murillo Duarte-Silva, Lucas D. Aguiar-da-Silva, Cesar A. A. Pereira, Domingos M. S. Pereira, Aruana J. M. C. R. Pinheiro, Lidio G. Lima-Neto, Elizabeth S. Fernandes, Cristina R. B. Cardoso, Luciana S. Branco-de-Almeida
Summary: Cinnamaldehyde treatment reduces periodontal bone loss, attenuates inflammatory mediators, and regulates human PBMC responses, suggesting its potential therapeutic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sho Yokoe, Akira Hasuike, Norihisa Watanabe, Hideki Tanaka, Hiroyuki Karahashi, Shin Wakuda, Osamu Takeichi, Takayuki Kawato, Hideki Takai, Yorimasa Ogata, Shuichi Sato, Kenichi Imai
Summary: Periodontitis is a common inflammatory condition that affects the supporting tissues of teeth. The role of Epstein-Barr virus (EBV) in the etiology of periodontitis is not well understood. This study found that inactivated EBV induces high levels of interleukin (IL)-6 and IL-8 in human gingival fibroblasts (HGFs), leading to inflammation and osteoclast differentiation, suggesting that EBV may contribute to the onset and progression of periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Leopoldo Cosme-Silva, Renan Dal-Fabbro, Luciano Tavares Angelo Cintra, Edilson Ervolino, Alana Sant'Ana do Prado, Daniel Pinto de Oliveira, Priscylla Goncalves Correia Leite de Marcelos, Joao Eduardo Gomes-Filho
Summary: The study showed that the multi-strain probiotic formula was effective in reducing inflammation and bone resorption in apical periodontitis induced in rats.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Plant Sciences
Salek Ahmed Sajib, Bjorn Gruebler, Cylia Oukacine, Etienne Delannoy, Florence Courtois, Caroline Mauve, Claire Lurin, Bertrand Gakiere, Thomas Pfannschmidt, Livia Merendino
Summary: Seedling development in darkness is regulated by both plastids and mitochondria, with inhibition of plastid gene expression leading to an exaggerated apical hook bending. Dysfunction of plastid gene expression also results in perturbation of mitochondrial metabolism and increased oxygen consumption. Signaling between plastids and mitochondria plays a crucial role in seedling architecture reprogramming.
Article
Immunology
Fuhua Yang, Yifei Zhang, Zhi Chen, Lu Zhang
Summary: VISTA is upregulated in inflammatory tissues of apical periodontitis, acting as a negative regulator to suppress inflammation and bone loss.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
A. C. Georgiou, P. Cornejo Ulloa, G. M. H. Van Kessel, W. Crielaard, S. V. Van der Waal
Summary: This systematic review summarized evidence on local production and systemic traces of reactive oxygen species (ROS) in apical periodontitis (AP). The findings suggest that ROS modulate cell signaling and cause oxidant imbalance locally at the site of AP, while these oxidative stress biomarkers are also found in blood and saliva of subjects with AP. Understanding the mechanism of ROS generation is crucial for enhancing treatment and diagnosis in AP.
ARCHIVES OF ORAL BIOLOGY
(2021)
Review
Immunology
Xutao Luo, Qianxue Wan, Lei Cheng, Ruoshi Xu
Summary: Chronic periapical periodontitis is a typical oral disease caused by odontogenic infection, leading to bone loss. Repairing jawbone defects and controlling infections are the main clinical challenges. Oral microorganisms have an impact on host cell metabolism and stimulate bone healing through immune responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Article
Biochemistry & Molecular Biology
Hyun-Jung Park, Sun-Young Yoon, Jung-Nam Park, Jae-Hee Suh, Hye-Seon Choi
Summary: This study found that doxorubicin-induced bone loss is partly caused by the upregulation of autophagy in osteoclasts (OCs). Doxorubicin induces autophagy in OCs through the mitochondrial reactive oxygen species (mROS)/transient receptor potential mucolipin 1 (TRPML1)/transcription factor EB (TFEB) axis pathway. The results show that doxorubicin-induced autophagy increases the area of OCs and bone resorption activity, while decreasing the number of OCs through apoptosis, resulting in bone loss. The autophagy inhibitor 3-methyladenine (3-MA) reverses the effects of doxorubicin by reducing the area of OCs, thus reversing doxorubicin-induced bone loss.
Article
Biochemistry & Molecular Biology
Kathrin Luntzer, Ina Lackner, Birte Weber, Yvonne Moedinger, Anita Ignatius, Florian Gebhard, Susann-Yvonne Mihaljevic, Melanie Haffner-Luntzer, Miriam Kalbitz
Summary: Periodontitis and tooth resorption are two oral diseases associated with destruction of tooth-supporting tissues. Research suggests that MCs and the complement system may play a role in alveolar bone and tooth resorption, as they were found to be increased in TR patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Anatomy & Morphology
Slavko Mojsilovic, Sonja S. Mojsilovic, Suncica Bjelica, Juan F. Santibanez
Summary: TGF-beta 1 and MDSCs play crucial roles in tumor progression, with simultaneous inhibition potentially improving the efficacy of cancer immunotherapy.
DEVELOPMENTAL DYNAMICS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Miroslav Andric, Jelena Jacimovic, Aleksandar Jakovljevic, Nadja Nikolic, Jelena Milasin
Summary: This systematic review critically analyzed gene polymorphisms in odontogenic keratocysts and ameloblastomas, finding several gene polymorphisms associated with these lesions. The study suggests that some gene polymorphisms may be risk factors for the development of these lesions.
Article
Dentistry, Oral Surgery & Medicine
Suzana Zivanovic, Milos Papic, Tamara Vucicevic, Marina Miletic Kovacevic, Nemanja Jovicic, Nadja Nikolic, Jelena Milasin, Verica Paunovic, Vladimir Trajkovic, Slobodanka Mitrovic, Miodrag L. Lukic, Aleksandra Lukic, Biljana Ljujic
Summary: After pulp exposure, DA rats developed significantly larger periapical lesions compared to AO rats, with genetically determined differences in immunopathology playing a significant role in defining the severity of periapical lesions.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Veterinary Sciences
Jakov Nisavic, Nenad Milic, Andrea Radalj, Milorad Mirilovic, Branislav Vejnovic, Milivoje Cosic, Aleksandra Knezevic, Ljubisa Veljovic, Aleksandar Zivulj
Summary: The study aimed to expand knowledge on the presence and genetics of PCV2 and PCV3 in wild boar populations in northeastern Serbia. PCV3 was not found, but 40.32% of organ samples from wild boars hunted between 2018 and 2019 tested positive for PCV2, indicating its significance in virus circulation. The most prevalent genotype was PCV2d, followed by PCV2b and PCV2a. Wild boars showed no signs of infection, suggesting they may be less susceptible to the disease. Monitoring wildlife is important for tracking virus dynamics in regions with free-range pig farming.
VETERINARNI MEDICINA
(2022)
Article
Virology
Marko Jankovic, Aleksandra Knezevic, Milena Todorovic, Irena Dunic, Biljana Mihaljevic, Ivan Soldatovic, Jelena Protic, Nevenka Mikovic, Vera Stoiljkovic, Tanja Jovanovic
Summary: This study found that chronic CMV infection was less prevalent in patients with B-cell malignancies compared to healthy controls. Furthermore, a significant inverse relationship between CMV seroprevalence and the annual incidence of B-cell neoplasms was observed globally.
Article
Biochemistry & Molecular Biology
Jugoslav Ilic, Aleksandra Milosavljevic, Milos Lazarevic, Maja Milosevic Markovic, Jelena Milasin, Milan Vucetic, Akhilanand Chaurasia, Vesna Miletic, Jelena Roganovic
Summary: This study aimed to investigate the protective effect of melatonin on HEMA- and CQ-treated human dental pulp cells (hDPCs), as well as its relevance in the mechanism of postoperative sensitivity in diabetic patients. The results showed that melatonin reversed the cytotoxic effects of HEMA and CQ on hDPCs by exerting anti-apoptotic and anti-inflammatory/antioxidant effects through iNOS-related pathways. This is the first evidence of melatonin's ability to counteract iNOS-mediated inflammatory and stress effects in HEMA- and CQ-treated hDPCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Giorgos Tzanetakis, Aleksandar Jakovljevic, Despina Koletsi, Jelena Jacimovic, Venkateshbabu Nagendrababu, Henry Fergus Duncan, Paul Michael Howell Dummer
Summary: This study aimed to evaluate the reporting quality of animal studies in the field of endodontics. The results showed that most of the studies had moderate reporting quality. It was concluded that adherence to PRIASE 2021 guidelines can improve the reporting quality of animal studies.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Venkateshbabu Nagendrababu, Henry F. F. Duncan, Ashraf F. F. Fouad, Lise-Lotte Kirkevang, Peter Parashos, Maria Pigg, Michael Vaeth, Jayakumar Jayaraman, Nandini Suresh, Aleksandar Jakovljevic, Paul M. H. Dummer
Summary: Observational studies are crucial for assessing the prevalence and impact of diseases and interventions. However, there is currently a lack of reporting guidelines for observational studies in the field of Endodontics. To address this gap, the PRIDE team has developed the PROBE 2023 guidelines, which integrate existing checklists and principles. This document serves as a guide for authors, providing explanations and examples for each item in the PROBE 2023 checklist.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Milica Jaksic Karisik, Milos Lazarevic, Dijana Mitic, Nadja Nikolic, Maja Milosevic Markovic, Drago Jelovac, Jelena Milasin
Summary: The failure of oral squamous cell carcinoma (OSCC) treatment is often attributed to cancer stem cells (CSCs) which are resistant to therapy. Micro RNA-21 has been found to play a significant role in the development of OSCC. This study aimed to investigate the multipotency of oral CSCs and evaluate the effects of differentiation on stemness, apoptosis, and miRNA expression. The experiments were conducted using a commercially available OSCC cell line (SCC25) and primary OSCC cultures from five patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Minja Milicic Lazic, Marko Lazic, Jelena Milasin, Danica Popovic, Peter Majeric, Rebeka Rudolf
Summary: This study aimed to analyze the basic properties of Cu-Al-Ni alloy and study its anticancer properties. The microstructure of Cu-Al-Ni alloy was found to be homogeneous with typical martensitic laths through chemical analysis and microhardness measurements. XRD analysis confirmed the presence of two phases, beta' (monoclinic) and gamma' (orthorhombic). Biocompatibility testing showed that the Cu-Al-Ni alloy exhibited a significant antineoplastic effect.
Article
Dentistry, Oral Surgery & Medicine
Henry F. Duncan, Lise-Lotte Kirkevang, Ove A. Peters, Ikhlas El-Karim, Gabriel Krastl, Massimo Del Fabbro, Bun San Chong, Kerstin M. Galler, Juan J. Segura-Egea, Moritz Kebschull
Summary: This article introduces the first S3-level clinical practice guidelines for endodontic treatment, developed by ESE, aimed at providing diagnostic and treatment approaches for patients with pulpitis and apical periodontitis, with the goal of preventing tooth loss.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Review
Dentistry, Oral Surgery & Medicine
Aleksandar Jakovljevic, Francesca Ideo, Jelena Jacimovic, Anita Aminoshariae, Venkateshbabu Nagendrababu, Amir Azarpazhooh, Elisabetta Cotti
Summary: This systematic review aimed to examine the potential link between apical periodontitis and gastrointestinal diseases. The analysis of existing studies revealed a potential association between impaired endodontic status and gastrointestinal diseases, but the evidence is limited. More research is needed to confirm this association.
JOURNAL OF ENDODONTICS
(2023)
Article
Biology
Ena Bukic, Jelena Milasin, Bosko Toljic, Jelena Jadzic, Djordje Jevtovic, Bozana Obradovic, Gordana Dragovic
Summary: Inevitable aging is accompanied by decline in vital functions. People with HIV infection may experience accelerated aging due to inflammation and long-term use of medications. Monitoring telomere length can help identify harmful effects associated with premature aging and age-related diseases. This study aimed to identify which HIV medications and changes in the body can lead to changes in telomere length, and found that the use of efavirenz is associated with shorter telomeres.
Article
Polymer Science
Tania Vanessa Pierfelice, Milos Lazarevic, Dijana Mitic, Nadja Nikolic, Milena Radunovic, Giovanna Iezzi, Adriano Piattelli, Jelena Milasin
Summary: The study investigated the effect of a newly formulated gel containing 5% 5-ALA in combination with red light (ALAD-PDT) on a premalignant oral mucosa cell line. The results showed that ALAD-PDT inhibited the proliferation and migration of DOK cells by inducing ROS and necrosis, and modulated the expression of apoptosis-related genes. This study suggests that ALAD-PDT could be a promising novel treatment for oral precancerous lesions.
Article
Dentistry, Oral Surgery & Medicine
Aleksandar Jakovljevic, Nadja Nikolic, Lucrezia Paterno Holtzman, Pierre Tournier, Alexis Gaudin, Luca Cordaro, Iva Milinkovic
Summary: The Notch pathway plays an important role in various vital cell functions and is involved in inflammation regulation, cell differentiation, and bone development. This review focuses on its role in alveolar bone resorption in conditions such as apical periodontitis, periodontal disease, and peri-implantitis. It highlights the potential of targeting the Notch signaling pathway for the treatment of these pathological conditions.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
