Article
Automation & Control Systems
Christian A. Cousin, Courtney A. Rouse, Warren E. Dixon
Summary: The split-crank FES cycle developed in this study utilizes a combined admittance-cadence controller to address rider asymmetries, ensure rider safety, and electrically stimulate leg muscles to pedal at the desired cadence. Experimental results demonstrate successful adaptation of the FES cycle to riders and offer a promising robotic rehabilitation strategy for individuals affected by movement disorders.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2021)
Article
Rehabilitation
Kenji Hachisuka, Mitsuhiro Ochi, Takashi Kikuchi, Satoru Saeki
Summary: The study compared the effectiveness of gait training with and without a peroneal nerve stimulation device in improving gait ability and ankle-specific body functions among stroke patients with foot drop. The results showed equivalent improvement in gait ability and body functions regardless of the use of the device.
CLINICAL REHABILITATION
(2021)
Article
Rehabilitation
Andreia S. P. Sousa, Ines Albuquerque Mesquita, Claudia Isabel Costa da Silva, Augusta Silva, Rui Macedo, Eukene Imatz-Ojanguren, Erik Hernandez, Thierry Keller, Juliana Moreira, Pedro Filipe Pereira da Fonseca, Rubim Santos
Summary: The study aimed to identify the optimal FES parameters for assisting the TOTL in poststroke participants and analyze the repeatability of UL kinematics. Reliable FES parameters were established, leading to high repeatability in UL kinematics for most cases.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Akhil Mohan, Jayme S. Knutson, David A. Cunningham, Morgan Widina, Kyle O'Laughlin, Tarun Arora, Xin Li, Ken Sakaie, Xiaofeng Wang, Ken Uchino, Ela B. Plow
Summary: This study aims to investigate the potential benefits of combining Contralaterally Controlled Functional Electrical Stimulation (CCFES) with a new rTMS approach that stimulates intact, contralesional higher motor cortices (cHMC) on severely impaired stroke survivors. By targeting spared neural substrates and engaging the unimpaired limb in movement of the impaired limb, a more favorable effect on paretic upper limb function is anticipated.
FRONTIERS IN NEUROLOGY
(2022)
Article
Rehabilitation
Natapatchakrid Thimabut, Pattarapol Yotnuengnit, Jittima Charoenlimprasert, Thipwimon Sillapachai, Satoshi Hirano, Eiichi Saitoh, Krisna Piravej
Summary: The study found that the robot-assisted gait training device combined with physiotherapy has better effects on improving ambulatory functions in patients with subacute stroke with hemiplegia compared to physiotherapy alone. It can lead to early improvements in walking ability and Barthel Index for Activities of Daily Living.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Engineering, Biomedical
Tyler Johnson, Dawn Taylor
Summary: This study investigates how modulating cocontraction of antagonist muscles during functional electrical stimulation (FES) can impact reaching performance and energy usage. The results suggest that dynamically modulating limb stiffness can significantly improve energy usage and movement performance. Therefore, brain-controlled FES becomes a more viable option for restoration of reaching after paralysis.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Gongkai Ye, Saima S. Ali, Austin J. Bergquist, Milos R. Popovic, Kei Masani
Summary: The study found that sequential stimulation (SEQ) can effectively reduce neuromuscular fatigue, but its adoption in research and clinical settings is limited. By using the SEQ adapter, signal integrity can be preserved, effectively increasing the utilization of SEQ in existing rehabilitation paradigms.
Article
Multidisciplinary Sciences
Marshall A. Trout, Abigail T. Harrison, Mark R. Brinton, Jacob A. George
Summary: Most neural stimulators lack the compliance voltage required for transcutaneous stimulation, whereas few high compliance voltage stimulators are bulky and not portable. To overcome this, a portable, programmable, multichannel, noninvasive neural stimulator has been designed and validated, capable of generating custom bipolar waveforms at +/-150V with high temporal resolution. The stimulator has been tested on a benchtop and a healthy population, proving its effectiveness for sensory and motor stimulation. This development and validation offer an important advancement in the accessibility and use of neural stimulation for education and research.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Matija Milosevic, Tomoya Nakanishi, Atsushi Sasaki, Akiko Yamaguchi, Taishin Nomura, Milos R. Popovic, Kimitaka Nakazawa
Summary: The study demonstrated that FEST can effectively improve motor function and increase cortical activations in individuals with chronic TBI. Short-term and long-term assessments indicated increased M1 activation after FEST intervention, which remained stable during follow-ups, suggesting a promising rehabilitation approach for TBI patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Robotics
Derek N. Wolf, Eric M. Schearer
Summary: Functional electrical stimulation (FES) offers promise for restoring reaching motions in individuals with spinal cord injuries. A trajectory optimization and model predictive control scheme was developed to improve the performance of FES-driven reaching controllers, incorporating knowledge of muscle capabilities and arm dynamics. The controller achieved 3D reaching motions with an average accuracy of 8.5 cm and demonstrated the ability to reach targets throughout the workspace. This control scheme has the potential to unlock daily reaching tasks for individuals with spinal cord injuries when further improved.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Chemistry, Analytical
Renato G. Barelli, Valter F. Avelino, Maria Claudia F. Castro
Summary: This paper presents the STIMGRASP, a home-based functional electrical stimulator for users with tetraplegia or hemiplegia. The system has eight independent symmetric biphasic constant current output channels and can communicate through USB and Bluetooth. It is powered by a rechargeable lithium-ion battery and provides more than 10 hours of continuous use. The focus of the system's development was on portability, usability, and wearability, resulting in a portable hardware with user-friendly mobile app control and an orthosis with electrodes.
Review
Chemistry, Analytical
Andreia S. P. Sousa, Juliana Moreira, Claudia Silva, Ines Mesquita, Rui Macedo, Augusta Silva, Rubim Santos
Summary: Stroke leads to significant impairment in upper limb function, and rehabilitation aims to restore pre-stroke motor skills by stimulating neuroplasticity. Functional electrical stimulation (FES) is recognized as a promising supplementary therapy in stroke rehabilitation. This study presents a comprehensive review on the usability of FES in post-stroke upper limb rehabilitation, including factors related to rehabilitation and critical appraisal of outcome measures. The review highlights FES as a promising tool to induce neuroplastic modifications in post-stroke rehabilitation, but the lack of studies evaluating FES usability through motor control outcomes and user satisfaction limits the definition of optimal therapeutical window for different functional tasks. FES systems integrating postural control muscles involving other anatomical regions are needed to improve upper limb function in post-stroke patients.
Article
Medicine, General & Internal
Md Akhlasur Rahman, Niraj Singh Tharu, Sylvia M. Gustin, Yong-Ping Zheng, Monzurul Alam
Summary: Spinal cord injury (SCI) is a debilitating injury with severe complications, but recent development of noninvasive electrical neuromodulation treatments offers hope for rehabilitation. Trans-spinal direct current stimulation (tsDCS) and trans-spinal pulsed current stimulation (tsPCS) have shown promising results in improving sensorimotor and autonomic functions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Marco Crepaldi, Rune Thorsen, Johanna Jonsdottir, Silvia Scarpetta, Lorenzo De Michieli, Mirco Di Salvo, Giorgio Zini, Matteo Laffranchi, Maurizio Ferrarin
Summary: This study successfully developed a wearable MeCFES device FITFES through user-centered design for the rehabilitation of the hemiplegic arm. The design includes minimal viable features and functionalities to ensure portability and usability of the device.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Chemistry, Analytical
Shirin Tajali, Kai Lon Fok, Pirashanth Theventhiran, Gongkai Ye, Hikaru Yokoyama, Kento Nakagawa, Kei Masani
Summary: This study aimed to develop a coaching system to help rowers initiate FES at the optimal timing, resulting in improved performance. The results showed that the coaching system provided the optimal timing for FES, leading to higher power and work outputs.
Article
Neurosciences
Izumi Nagashima, Kotaro Takeda, Yusuke Harada, Hideki Mochizuki, Nobuaki Shimoda
Summary: The study delves into the potential value of mental imagery of movement in rehabilitation tasks and the impact of cognitive strategy. Young participants tend to use the visual imagery strategy, whereas the choice of strategy among middle-aged and elderly individuals is influenced by their performance ability.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Orthopedics
Naoto Endo, Daisuke Ishii, Kiyoshige Ishibashi, Satoshi Yamamoto, Kotaro Takeda, Yutaka Kohno
Summary: This study investigated the immediate effects of NMES on the corticospinal excitability of the infraspinatus muscle in healthy subjects. The results showed that NMES significantly increased the MEP amplitude of the muscle without affecting Mmax, suggesting that NMES can increase CST excitability without producing immediate changes in neuromuscular junction or muscle hypertrophy.
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2021)
Article
Physiology
Hiroshi Onimaru, Itaru Yazawa, Kotaro Takeda, Isato Fukushi, Yasumasa Okada
Summary: This study revealed the existence of NTS cells that are sensitive to hypercapnia and hypoxia, suggesting that astrocytes in the NTS region could serve as central gas sensors.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Chemistry, Analytical
Akira Umeda, Masahiro Ishizaka, Akane Ikeda, Kazuya Miyagawa, Atsumi Mochida, Hiroshi Takeda, Kotaro Takeda, Isato Fukushi, Yasumasa Okada, David Gozal
Summary: Measuring carbon dioxide concentrations is crucial in respiratory clinical practice, providing valuable information on gas exchange and ventilation. Various methods, such as assessing PaCO2 and using PtcCO2 monitors, are essential for evaluating respiratory function and disorders. Monitoring end-tidal PCO2 has become more widespread due to its multiple applications in different medical settings.
Article
Neurosciences
Daisuke Ishii, Kiyoshige Ishibashi, Hiroshi Yuine, Kotaro Takeda, Satoshi Yamamoto, Yuki Kaku, Arito Yozu, Yutaka Kohno
Summary: Hyper-adaptability is crucial for recovering from disabilities, such as motor paralysis and sensory impairment. Research indicates that the ipsilateral descending pathway is activated during recovery from motor paralysis, while there may not be neural connectivity in the left-right interaction of the somatosensory pathway.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Article
Clinical Neurology
Rikitaro Sako, Satoshi Yamamoto, Kotaro Takeda, Masahiro Wakatabi, Minoru Daira, Tetsuichi Hondera, Takayuki Oota, Ami Fujii, Yoshitaka Okamoto, Satoshi Sugiyama, Yoshifumi Ozasa
Summary: A rare case of bilateral medial medullary infarctions was reported, with a 64-year-old patient showing typical clinical symptoms and diagnosed through multiple imaging examinations. The infarctions were likely caused by atherosclerosis in the bilateral vertebral arteries. The combined use of TOF-MRA and BPAS-MRI could improve diagnostic accuracy and aid in post-stroke management.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2021)
Article
Neurosciences
Itaru Yazawa, Shuntaro Okazaki, Shigefumi Yokota, Kotaro Takeda, Isato Fukushi, Masashi Yoshizawa, Hiroshi Onimaru, Yasumasa Okada
Summary: The study suggests that putative astrocytes and neurons in the ventral horn of the spinal cord may play a crucial role in maintaining synaptic function and metabolism to generate rhythms and patterns of locomotor-like activity by communicating with central pattern generator networks.
NEUROSCIENCE LETTERS
(2022)
Article
Rehabilitation
Hitoshi Ohnishi, Hiroyuki Miyasaka, Naoki Shindo, Kazuki Ito, Shiori Tsuji, Shigeru Sonoda
Summary: The combination of RFE and NMES therapy can improve distal function in stroke patients with severe upper limb paralysis.
OCCUPATIONAL THERAPY INTERNATIONAL
(2022)
Article
Neurosciences
Isato Fukushi, Shigefumi Yokota, Kotaro Takeda, Jiro Terada, Akira Umeda, Masashi Yoshizawa, Yosuke Kono, Yohei Hasebe, Hiroshi Onimaru, Mieczyslaw Pokorski, Yasumasa Okada
Summary: This study investigates the effects of the insomnia drug Suvorexant on the respiratory system and shows the involvement of orexin in respiratory control. Suvorexant suppresses the augmented ventilation in hypercapnia, but does not affect ventilation.
Article
Infectious Diseases
Yu Takahashi, Hideaki Wakita, Takuma Ishihara, Hideto Okazaki, Akihiro Ito, Mitsunaga Iwata, Shigeru Sonoda, Yohei Doi
Summary: Healthcare-associated COVID-19 among vulnerable patients leads to disproportionate morbidity and mortality. Early pharmacologic intervention may reduce negative sequelae and improve survival in such settings. This study aimed to describe outcome of patients with healthcare-associated COVID-19 who received early short-course remdesivir therapy.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Physiology
Masashi Yoshizawa, Isato Fukushi, Kotaro Takeda, Yosuke Kono, Yohei Hasebe, Keiichi Koizumi, Keiko Ikeda, Mieczyslaw Pokorski, Takako Toda, Yasumasa Okada
Summary: Microglia play an important role in the regulation of cardiorespiratory activities. They contribute to blood pressure regulation under normal blood oxygen conditions and enhance ventilatory responses during hypoxia.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Shota Itoh, Takahiro Ogino, Kenji Kawakami, Kosuke Miyake, Honoka Iyoda, Hidenori Imaizumi, Misaki Nakajima, Haruna Kitahara, Shigeru Sonoda
Summary: This study aimed to verify the predictive ability of SPPB for walking independence. By conducting physical assessments and functional independence measure cognitive evaluations in stroke patients, the researchers found that SPPB and FIM-C were factors influencing walking independence. However, using SPPB alone cannot determine walking independence, and a combined assessment with cognitive function may provide more accurate results.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Health Care Sciences & Services
Atsumi Takeo, Hideto Okazaki, Kotaro Takeda, Yuki Nakagawa, Shigeru Sonoda
Summary: This study aimed to develop a system for measuring trunk and pelvis range of motion (ROM) during wheelchair propulsion and to assess the reproducibility of posture changes and cyclic fluctuations. Motion recorders were attached to the sternum and pelvis of fifteen healthy adults, and a pressure sensor was attached to the right heel. Results showed intraclass correlation coefficients of maximum, minimum, and amplitude of cyclic variation ranging from 0.65 to 0.84.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Neurosciences
Isato Fukushi, Keiko Ikeda, Kotaro Takeda, Masashi Yoshizawa, Yosuke Kono, Yohei Hasebe, Mieczyslaw Pokorski, Yasumasa Okada
Summary: Severe hypoxia can induce seizures and worsen the state of the affected individuals. Recent studies have shown that brain microglia are involved in both respiratory and ictal processes. This study investigated the interaction between microglia and hypoxia-induced seizures using mice as a model.
FRONTIERS IN NEURAL CIRCUITS
(2023)