4.7 Article

A high stiffness bio-inspired hydrogel from the combination of a poly(amido amine) dendrimer with DOPA

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 94, Pages 16786-16789

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05643h

Keywords

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Funding

  1. National Natural Science Foundation of China [21174005, 21274004, 81500894]
  2. Specialized Research Fund for the Doctoral Program of China [SRFDP20125503120009]

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A robust biodegradable hydrogel is constructed from two components containing G4.0 PAMAM and DOPA, which displays excellent interconnected porous 3D networks, higher mechanical strength, low and stable swelling and good biocompatibility. A mouse CSD model in vivo evidences that moderate bone-like tissue and extensive bony tissue are observed when the hydrogel is implanted.

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