4.7 Article

Highly sensitive signal-on'' electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 78, Pages 14578-14581

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc06156c

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Funding

  1. National Natural Science Foundation of China [21475062, 21175069]
  2. Research Fund for the Doctoral Program of Higher Education of China [20113207110005]
  3. Foundation of the Jiangsu Education Committee [11KJA150003]
  4. Priority Academic Program Development of Jiangsu Higher Education Institutions

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A signal-on'' electrochemiluminescent DNA biosensing platform was proposed based on the dual quenching and strand displacement reaction. This novel signal-on'' detection strategy revealed its sensitivity in achieving a detection limit of 2.4 aM and its selectivity in distinguishing single nucleotide polymorphism of target DNA.

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