Article
Medicine, Research & Experimental
Xin Li, Shuang Zhao, Xiaohui Bian, Lining Zhang, Lixia Lu, Shiyao Pei, Liang Dong, Wensheng Shi, Lingjuan Huang, Xiyuan Zhang, Mingliang Chen, Xiang Chen, Mingzhu Yin
Summary: Our study investigates the changes in tumor microenvironment (TME) between primary and recurrent cutaneous squamous cell carcinoma (cSCC) using single-cell RNA sequencing (scRNA-seq). We identified an immunosuppressed microenvironment in recurrent cSCC, with T cell exclusion and enrichment of SPP1+ tumor-associated macrophages (TAMs). CD8+ T cells showed exhaustion and low inflammatory features, while SPP1+ TAMs displayed pro-tumor characteristics. Different subgroups of SPP1+ TAMs exhibited distinct functions. A subset of tumor-specific keratinocytes (TSKs) showed significant epithelial-mesenchymal transition (EMT) features, possibly due to their interaction with IL7R+ cancer-associated fibroblasts (CAFs). We also found that the growth factor/cytokine Midkine (MDK) played a role in different cell-cell interactions in cSCC with different staging.
Article
Dentistry, Oral Surgery & Medicine
Hong Zhang, Zhenhua Wang, Zhongti Zhang
Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.
Article
Cell Biology
Jie Gao, Ying Meng, Xin Ge, Chen-Xing Hou, Qing-Hai Zhu, Yi-Zhou Wang, Li-Fan Sun, Chen-Xing Wang, Huai-Qi Li, Tianzhu Zhang, Jin-Hai Ye
Summary: This study revealed the expression and function of SATB2 in oral squamous cell carcinoma, showing that high expression of SATB2 is associated with poor prognosis. Overexpression of SATB2 promotes proliferation, migration, invasion, and tumor growth of OSCC cells, and NOX4 is identified as a downstream target of SATB2. This suggests that SATB2 may play a key role in OSCC tumorigenesis and could be a potential target for future therapeutic development.
CELLULAR SIGNALLING
(2021)
Article
Dentistry, Oral Surgery & Medicine
Bowen Li, Yuxun Ding, Chuying Huo, Siqi Ren, Suling Chen, Haizhang He, Shurui Li, Xiaojuan Wang, Meifeng Cen, Hongyu Yang, Jinsong Li
Summary: This study identified circ-OCAC as a potential therapeutic strategy for oral squamous cell carcinoma (OSCC) by inhibiting the growth and metastasis of OSCC through blocking the PI3K/Akt signaling pathway.
Article
Dentistry, Oral Surgery & Medicine
Lingling Cui, Chao Huang, Dun Zhou
Summary: This study revealed that circCDR1as acts as an oncogene in oral squamous cell carcinoma (OSCC) by upregulating SLC7A11 through targeting miR-876-5p, promoting tumor growth and metastasis.
Article
Biochemistry & Molecular Biology
Li Li, Ye Yin, Fanglong Nan, Zeyu Ma
Summary: circ_LPAR3 is upregulated in oral squamous cell carcinoma (OSCC), and its knockdown can inhibit tumor growth and angiogenesis by sponging miR-513b-5p and activating VEGFC and AKT1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Ying Lou, Liuyang Ren, Lu Wang
Summary: In this study, the role of a novel circRNA, circ_0049396, and its underlying mechanism in oral squamous cell carcinoma (OSCC) were investigated. The findings showed that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. Based on these results, circ_0049396 could be a potential therapeutic agent for OSCC.
Article
Biochemistry & Molecular Biology
Yuki Fukawa, Kou Kayamori, Maiko Tsuchiya, Tohru Ikeda
Summary: We found that oral squamous cell carcinoma (OSCC) cells can induce osteoclastogenesis without upregulating NFATc1, the master transcriptional factor. Through gene expression and protein analysis, IL-1, IL-6, IL-8, and CXCL1 were identified as inflammatory cytokines preferentially expressed in the osteoclastogenic OSCC cell line, NEM. IL-1 was confirmed to stimulate both OSCC-induced and RANKL-induced osteoclastogenesis, suggesting its role in bone resorption induced by OSCC infiltration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
Summary: This study identified LCN2 as a potential target for the treatment of OSCC. Inhibition of LCN2 expression effectively inhibited OSCC proliferation and metastasis by inhibiting EGFR phosphorylation and downstream signaling activation. LCN2 enhances the recycling of EGFR, activating the EGFR-MEK-ERK cascade. Inhibition of LCN2 significantly inhibited EGFR activation, leading to significant inhibition of tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Minmin Ji, Yuesheng Lv, Chaoqun Chen, Dingya Xing, Chao Zhou, Jinyao Zhao, Yangfan Qi, Jinrui Zhang, Yang Wang, Xiang Ma, Wei Xu, Wenjing Zhang, Xiaojie Li
Summary: This study found that metformin can inhibit the proliferation and migration of oral squamous cell carcinoma by regulating RNA alternative splicing, especially the splicing of the NUBP2 gene, which inhibits cancer cell proliferation.
Article
Oncology
Jingpeng Liu, Xiao Jiang, Ailing Zou, Zhaoyi Mai, Zhijie Huang, Liying Sun, Jianjiang Zhao
Summary: The study identified a unique circRNA, circIGHG, which is significantly upregulated in oral squamous cell carcinoma (OSCC) and associated with poor prognosis. It promotes OSCC invasion and metastasis by interacting with miR-142-5p and IGF2BP3, with epithelial-mesenchymal transition being the main mechanism. These findings suggest that circIGHG could serve as a biomarker and therapeutic target for early diagnosis and treatment of OSCC.
Article
Immunology
Ruowei Li, Yifan Zhou, Miaomiao Zhang, Ruiqi Xie, Ning Duan, Hong Liu, Yao Qin, Jingjing Ma, Zhiyuan Li, Pei Ye, Wenmei Wang, Xiang Wang
Summary: EVs derived from oral squamous cell carcinoma (OSCC) cells can promote tumor progression by altering the tumor microenvironment, causing an imbalance of inflammatory cytokines, inducing immunosuppression, and contributing to overactivation of the IL-17A-induced signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan Chao, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu-Yun Zhao, Wei Cao
Summary: A highly expressed lncRNA DUXAP9, found in oral squamous cell carcinoma (OSCC), is positively associated with poor prognosis. DUXAP9 promotes OSCC cell proliferation, migration, invasion, and tumor growth through the upregulation of N-cadherin, Vimentin, Ki67, PCNA, and EZH2 and downregulation of E-cadherin. Yin Yang 1 (YY1) activates the transcription of DUXAP9 in OSCC. Moreover, DUXAP9 interacts with EZH2 and inhibits its degradation, thereby blocking its translocation from the nucleus to the cytoplasm. DUXAP9 may serve as a promising therapeutic target for OSCC.
Article
Cell Biology
Simin Li, Zhaoyi Mai, Wenli Gu, Anthony Chukwunonso Ogbuehi, Aneesha Acharya, George Pelekos, Wanchen Ning, Xiangqiong Liu, Yupei Deng, Hanluo Li, Bernd Lethaus, Vuk Savkovic, Rudiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Hao Wang, Hui Xiao, Jianjiang Zhao
Summary: Deep learning identified two survival subtypes of OSCC, which can assist clinicians in categorizing immunocompromised patients into two subpopulations for targeted drug therapy, ultimately improving survival rates and offering novel therapeutic strategies in precision medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Barillari, Ombretta Melaiu, Marco Gargari, Silvia Pomella, Roberto Bei, Vincenzo Campanella
Summary: CD147 plays a crucial role in the development of oral squamous cell carcinoma (OSCC) and its expression/activity is closely associated with disease progression. It may serve as a potential target for monitoring and treating OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)