Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination

Increased Tumor-Specific CD8+ T Cell Induction by Dendritic Cells Matured with a Clinical Grade TLR-Agonist in Combination with IFN-γ

(2017) J. Vanderlocht et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25

(2015) Dalil Hannani et al.   CELL RESEARCH

The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome

(2015) Cleo Goyvaerts et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β

(2015) Dhifaf Sarhan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I IFN-mediated synergistic activation of mouse and human DC subsets by TLR agonists

(2015) Martin Kreutz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Potency of Both Human Th1 and NK Helper Cell Activation is Determined by IL-12p70-Producing PAMP-Matured DCs

(2015) Tammy Oth et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Toxicity Patterns With Immunomodulating Antibodies and Their Combinations

(2015) John B.A.G. Haanen et al.   SEMINARS IN ONCOLOGY

An optimized peptide vaccine strategy capable of inducing multivalent CD8+T cell responses with potent antitumor effects

(2015) Hyun-Il Cho et al.   OncoImmunology

Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases

(2014) Sofie Wilgenhof et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Natural Killer Cells: The Secret Weapon in Dendritic Cell Vaccination Strategies

(2014) Catharina H.M.J. Van Elssen et al.   CLINICAL CANCER RESEARCH

Dendritic Cell Cross Talk with Innate and Innate-like Effector Cells in Antitumor Immunity: Implications for DC Vaccination

(2014) Jasper J. P. van Beek et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The immune contexture of primary and metastatic human tumours

(2014) Nicolas A Giraldo et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer vaccine adjuvants – recent clinical progress and future perspectives

(2014) Abid H. Banday et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor-Specific CD4+ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8+ T Cells

(2014) S. B. J. Wong et al.   JOURNAL OF IMMUNOLOGY

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

Monitoring the Initiation and Kinetics of Human Dendritic Cell-Induced Polarization of Autologous Naive CD4+ T Cells

(2014) Tammy Oth et al.   PLoS One

IL-18-Primed Helper NK Cells Collaborate with Dendritic Cells to Promote Recruitment of Effector CD8+ T Cells to the Tumor Microenvironment

(2013) J. L. Wong et al.   CANCER RESEARCH

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

Turning Tumors into Vaccines: Co-opting the Innate Immune System

(2013) Jasper G. van den Boorn et al.   IMMUNITY

IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity

(2013) Beatriz M. Carreno et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Toll-Like Receptor 4 Engagement Drives Differentiation of Human and Murine Dendritic Cells from a Pro- into an Anti-Inflammatory Mode

(2013) Romana Luger et al.   PLoS One

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

Limited Induction of Tumor Cross-Reactive T Cells without a Measurable Clinical Benefit in Early Melanoma Patients Vaccinated with Human Leukocyte Antigen Class I-Modified Peptides

(2012) P. Filipazzi et al.   CLINICAL CANCER RESEARCH

Tumor-Infiltrating FoxP3+ Tregs and CD8+ T Cells Affect the Prognosis of Hepatocellular Carcinoma Patients

(2012) Yong Huang et al.   DIGESTION

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

Cancer classification using the Immunoscore: a worldwide task force

(2012) Jérôme Galon et al.   Journal of Translational Medicine

Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial

(2012) Ravi A Madan et al.   LANCET ONCOLOGY

Combined Tbet and IL12 Gene Therapy Elicits and Recruits Superior Antitumor Immunity In Vivo

(2012) Yanyan Qu et al.   MOLECULAR THERAPY

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

NK Cells: Key to Success of DC-Based Cancer Vaccines?

(2012) E. Lion et al.   ONCOLOGIST

Lymphocyte-polarized dendritic cells are highly effective in inducing tumor-specific CTLs

(2012) Erik Berk et al.   VACCINE

Lymphocyte-polarized DC1s

(2012) Erik Berk et al.   OncoImmunology

Trial watch

(2012) Laura Senovilla et al.   OncoImmunology

Inflammation restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation

(2011) C. H. M. J. Van Elssen et al.   BLOOD

Generation of immunogenic and tolerogenic clinical-grade dendritic cells

(2011) Tahereh Kalantari et al.   IMMUNOLOGIC RESEARCH

Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells

(2011) Jeffrey L. Wong et al.   JOURNAL OF IMMUNOTHERAPY

Engineering Dendritic Cells to Enhance Cancer Immunotherapy

(2011) Jeanette E Boudreau et al.   MOLECULAR THERAPY

Tumour-loaded α-type 1-polarized Dendritic Cells from Patients with Chronic Lymphocytic Leukaemia Produce a Superior NK-, NKT- and CD8+ T Cell-attracting Chemokine Profile

(2011) Karin Gustafsson et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15

(2010) L. Vujanovic et al.   BLOOD

PGE2 transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells

(2010) R. Muthuswamy et al.   BLOOD

Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy

(2010) Gerty Schreibelt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

(2010) J. Mitsui et al.   CLINICAL CANCER RESEARCH

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

(2010) J. F. M. Jacobs et al.   CLINICAL CANCER RESEARCH

Klebsiella pneumoniae-triggered DC recruit human NK cells in a CCR5-dependent manner leading to increased CCL19-responsiveness and activation of NK cells

(2010) Catharina H. M. J. Van Elssen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity

(2010) Simon S Jensen et al.   Journal of Inflammation-London

Evaluation of natural killer cell defense in oral squamous cell carcinoma

(2010) Mahiye Reyhan Türkseven et al.   ORAL ONCOLOGY

Polarized dendritic cells as cancer vaccines: Directing effector-type T cells to tumors

(2010) Pawel Kalinski et al.   SEMINARS IN IMMUNOLOGY

Dendritic Cell-Based Cancer Gene Therapy

(2009) Evelien L.J.M. Smits et al.   HUMAN GENE THERAPY

NK cells enhance the induction of CTL responses by IL-15 monocyte-derived dendritic cells

(2009) Melinda Y Hardy et al.   IMMUNOLOGY AND CELL BIOLOGY

Toll-like receptor agonists in cancer therapy

(2009) Sylvia Adams   Immunotherapy

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

(2009) Franck Pagès et al.   JOURNAL OF CLINICAL ONCOLOGY

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro

(2009) M. W. Lipscomb et al.   JOURNAL OF IMMUNOLOGY

Independent Regulation of Chemokine Responsiveness and Cytolytic Function versus CD8+ T Cell Expansion by Dendritic Cells

(2009) P. B. Watchmaker et al.   JOURNAL OF IMMUNOLOGY

Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties

(2009) Sébastien Anguille et al.   Journal of Translational Medicine

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

(2009) Yusuke Nakanishi et al.   NATURE

TLR expression and NK cell activation after human yellow fever vaccination

(2009) Patrícia Cristina da Costa Neves et al.   VACCINE

Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56brightCD16− cells and display an impaired capability to kill tumor cells

(2008) Paolo Carrega et al.   CANCER

Recruitment and Activation of Natural Killer Cells In vitro by a Human Dendritic Cell Vaccine

(2008) K. Gustafsson et al.   CANCER RESEARCH

Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients

(2008) Lun Cai et al.   CLINICAL IMMUNOLOGY

Paradigm Shifts in Cancer Vaccine Therapy

(2008) Jeffrey Schlom et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

(2008) Joseph D. Miller et al.   IMMUNITY

Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms

(2008) Baidong Hou et al.   IMMUNITY

Dendritic Cells In Vivo: A Key Target for a New Vaccine Science

(2008) Ralph M. Steinman   IMMUNITY

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

(2008) Olivier Joffre et al.   IMMUNOLOGICAL REVIEWS

CD40 ligation restores type 1 polarizing capacity in TLR4-activated dendritic cells that have ceased interleukin-12 expression

(2008) Alexander Michael Dohnal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparative evaluation of techniques for the manufacturing of dendritic cell-based cancer vaccines

(2008) Alexander Michael Dohnal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

(2008) Erwan Mortier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

(2008) Silvia Piconese et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

(2008) C. Trumpfheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sipuleucel-T: A Vaccine for Metastatic, Asymptomatic, Androgen-Independent Prostate Cancer

(2007) Punam H Patel et al.   ANNALS OF PHARMACOTHERAPY

Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer

(2007) G. Esendagli et al.   LUNG CANCER