Article
Emergency Medicine
Daniel J. McCabe, Joshua B. Radke, Bryan Z. Wilson
Summary: Bupropion overdose requires significant resource utilization and high levels of medical care, which may further increase with expanding indications for its use.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Samuel Robinson
Summary: We report a case of a 14-year-old female who ingested an overdose of bupropion, resulting in seizures and cardiotoxicity. The patient responded well to supportive care and lidocaine drip, and the QT interval was eventually narrowed. This successful treatment of ventricular tachycardia and ventricular fibrillation with lidocaine bolus and drip, leading to shortening of the QT interval, has not been previously reported.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Cell Biology
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu
Summary: Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF). DDX3X plays a role in pro-survival stress granule (SG) assembly, but its role in DILI is unknown. This study revealed that DDX3X expression is decreased in DILI patients and DDX3X deficient mice. DDX3X deficiency aggravated liver injury in multiple DILI models by enhancing oxidative stress, hepatocyte death, and inflammatory responses.
CELL DEATH & DISEASE
(2023)
Article
Pharmacology & Pharmacy
Omid Mehrpour, Farhad Saeedi, Varun Vohra, Jafar Abdollahi, Farshad M. Shirazi, Foster Goss
Summary: This study aimed to predict outcomes of bupropion overdose using a decision tree approach. The results showed that multiple seizures, conduction disturbance, intentional exposure, and confusion were the most influential factors to predict the outcome of bupropion exposure. Coma and seizure, including single, multiple and status, were the most important factors to predict major outcomes.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Melanie Jaeger, Greg W. Hosier, Thomas McGregor, Darren Beiko, Sarah Medina Kasasni, Christopher M. Booth, Marlo Whitehead, D. Robert Siemens
Summary: This study found that females are more likely than males to demonstrate long term opioid use following an episode of renal colic. Females are more likely to utilize mental health services and be on a provincial disability program. Age, income, mental health diagnoses, and prescribed opioid dosage were associated with persistent opioid use in both genders.
Article
Medicine, General & Internal
Manoj Kumar, Maasila Arcot Thanjan, Natarajan Gopalakrishnan, Dhanapriya Jeyachandran, Dineshkumar Thanigachalam, Sakthirajan Ramanathan
Summary: Snake bite-induced AKI in India has a 20.7% incidence rate, with mortality associated with shock and thrombocytopenia. Long-term adverse renal outcomes occurred in 48.8% of patients, with older age and longer duration on dialysis significantly linked to these outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Piotr Lagosz, Jan Biegus, Szymon Urban, Robert Zymlinski
Summary: Cardiorenal syndrome (CRS) is a complex and heterogeneous spectrum of symptoms that has posed challenges for cardiologists for many years. The coexistence of heart failure (HF) and deteriorated renal function adds to these challenges and is a strong predictor of poor outcomes. However, with the development of new renal assessment methods, we now have the opportunity to treat CRS more effectively than ever before. This review focuses on explaining the pathophysiology, recent advances, and current practices of monitoring renal function in patients with acute CRS, aiming to improve patient care and guide treatment strategies.
Review
Pharmacology & Pharmacy
Abhi Dutta, Shubham Saha, Ajay Bahl, Anupam Mittal, Trayambak Basak
Summary: Cardiorenal syndrome is a broad spectrum disorder affecting the heart and kidneys. India has a high burden of acute cardiorenal syndrome, with 46.1% of patients diagnosed in India. Acute cardiorenal syndrome involves sudden kidney deterioration in acute heart failure patients. The pathophysiology includes hyperactivation of the sympathetic nervous system and the renin-angiotensin-aldosterone system. Complications increase the risk of mortality, making it a global healthcare burden. Current biomarkers have limitations in early detection, highlighting the need for novel proteomic biomarkers to prevent progression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Toxicology
Michael C. Beuhler, Henry A. Spiller, Dalia Alwasiyah, Robert Bassett, Jeanette Trella, Martin Huecker, Ashley N. Webb
Summary: The study reviewed cases of unintentional ingestion of single substance bupropion in adults and found that outcomes were generally mild and dose-related. Home management may be an option for appropriate patients with doses up to 900 mg. Jittery/anxious/agitated symptoms were significantly associated with the development of seizures and/or adverse events.
CLINICAL TOXICOLOGY
(2022)
Review
Toxicology
Tony N. Rianprakaisang, Colin T. Prather, Amber L. Lin, Brian P. Murray, Robert G. Hendrickson
Summary: Based on analysis of bupropion overdose cases, clinical features associated with seizures include QTc > 500, tachycardia, and age 13-18 years. However, a specific QTc value may not be a useful predictor of seizures.
CLINICAL TOXICOLOGY
(2021)
Article
Critical Care Medicine
Lakhmir S. Chawla
Summary: Studies have shown that a uremic milieu can enhance renal recovery and decrease kidney fibrosis in acute kidney injury (AKI). In addition, a reduction in markers of inflammation has been observed in the injured kidney. Therefore, the uremic milieu has a protective effect on AKI.
Review
Infectious Diseases
Alberto Corona, Dario Cattaneo, Nicola Latronico
Summary: Critically ill patients with sepsis or septic shock have a worse prognosis due to a higher mortality rate and longer hospital stay. The proper use of antibiotics is crucial as it can affect the pharmacokinetics and pharmacodynamics in these patients. About 50% of septic patients develop acute renal failure, requiring continuous renal replacement therapy, which greatly affects the elimination rate of antibiotics. Adjustments in antibiotic doses are necessary in patients with acute renal failure based on glomerular filtration rate, while dosages should be increased in those undergoing continuous renal replacement therapy.
Article
Emergency Medicine
Brian P. Murray, Joseph E. Carpenter, Joshua Sayers, Michael Yeh, Jordan Beau, Emily A. Kiernan, Matthew J. Wolf, Tonya A. Bolton, Ziad Kazzi
Summary: Even though bupropion is not directly serotonergic, overdose can lead to serotonin syndrome. Awareness of its potential serotonergic activity is crucial for accurate assessment and treatment of this dangerous condition.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Isabel Fuentes-Calvo, Cristina Cuesta, Sandra M. Sancho-Martinez, Omar A. Hidalgo-Thomas, Maria Paniagua-Sancho, Francisco J. Lopez-Hernandez, Carlos Martinez-Salgado
Summary: This study identified subclinical sequelae persisting after recovery from AKI in rats, including histological and functional alterations, as well as susceptibility to new AKI episodes. Additionally, potential diagnostic tools were found in the FST and urinary [TIMP-2]*[IGFBP7] product, to monitor the sequelae and kidney vulnerability after apparent recovery from AKI.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Ya Zhou, Lijuan Zhu, Biaoxiang Liu, Weiping Xu, Xingyue Yang, Yi Liu, Bankang Ruan, Shujuan Yi, Baoshuai Liang, Guoqi Dong, Jiaguo Huang
Summary: This study presents a new approach for early detection of drug-induced renal failure using activatable reporters. The developed probe can accumulate in the kidneys and respond to specific indicators, enabling sensitive detection of renal failure at an early stage. Additionally, the probe can be excreted in urine, allowing for remote detection and prediction of renoprotective efficacy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
