Review
Biochemistry & Molecular Biology
Shaolei Ma, Changsheng Xu, Shijiang Liu, Xiaodi Sun, Renqi Li, Mingjie Mao, Shanwu Feng, Xian Wang
Summary: Current clinical trials suggest that corticosteroid use may reduce overall mortality in severe COVID-19 patients, decrease disease progression, and not increase the incidence of serious adverse events. However, more trials are needed to confirm these results.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Infectious Diseases
Fangyuan Tian, Qiyi Feng, Zhaoyan Chen
Summary: This study aimed to evaluate the efficacy and safety of molnupiravir in the treatment of COVID-19. The meta-analysis results showed that molnupiravir can accelerate the rehabilitation of COVID-19 patients, but it does not significantly reduce mortality and hospitalisation.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Multidisciplinary Sciences
Soheil Hassanipour, Morteza Arab-Zozani, Bahman Amani, Forough Heidarzad, Mohammad Fathalipour, Rudolph Martinez-de-Hoyo
Summary: The meta-analysis of Favipiravir in the treatment of COVID-19 showed significant clinical improvement in the Favipiravir group compared to the control group after seven days of hospitalization. However, there was no significant difference in viral clearance and oxygen therapy requirement between the two groups. The mortality rate was approximately 30% lower in the Favipiravir group, but this finding was not statistically significant.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Ching-Yi Chen, Wang-Chun Chen, Chi-Kuei Hsu, Chien-Ming Chao, Chih-Cheng Lai
Summary: JAK inhibitors can reduce the mortality rate and increase the recovery rate of COVID-19 patients, as well as shorten the recovery time. The use of JAK inhibitors also lowers the rate of patients needing invasive mechanical ventilation without increasing the risk of adverse events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Paul Guedeney, Gennaro Giustino, Sabato Sorrentino, Bimmer E. Claessen, Anton Camaj, Deborah N. Kalkman, Birgit Vogel, Samantha Sartori, Salvatore De Rosa, Usman Baber, Ciro Indolfi, Gilles Montalescot, George D. Dangas, Robert S. Rosenson, Stuart J. Pocock, Roxana Mehran
Summary: Treatment with alirocumab or evolocumab is associated with reduced risk of myocardial infarction, stroke, and coronary revascularization, with a favorable safety profile.
EUROPEAN HEART JOURNAL
(2022)
Review
Health Care Sciences & Services
Yong-Qiang Wu, Yi Long, Wei-Jie Peng, Cheng Gong, Yue-Quan Liu, Xu-Miao Peng, Yan-Biao Zhong, Yun Luo, Mao -Yuan Wang
Summary: Telerehabilitation can improve the symptoms and quality of life of fibromyalgia patients. However, the safety of telerehabilitation remains uncertain due to the lack of sufficient evidence. More rigorously designed trials are needed in the future to verify the safety and efficacy of telerehabilitation in fibromyalgia.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Immunology
Ali Pormohammad, Mohammad Zarei, Saied Ghorbani, Mehdi Mohammadi, Mohammad Hossein Razizadeh, Diana L. Turner, Raymond J. Turner
Summary: This study systematically reviewed the clinical features of COVID-19 vaccines in clinical trials, finding that mRNA-based and adenovirus-vectored vaccines exhibited different efficacy and side effect profiles. Both types of vaccines showed high efficacy after the first and second doses, with mRNA-based vaccines having higher reported side effects.
Review
Medicine, General & Internal
Jiayu Wen, Quanxian Liu, Daoyan Tang, Jian-Qing He
Summary: Based on a systematic review and meta-analysis of published randomized controlled trials, the effectiveness of Bacillus Calmette-Guerin (BCG) vaccination in preventing COVID-19 infection and severe disease is inconclusive. The rates of infection, hospitalization, ICU admission, and mortality did not differ significantly between the BCG vaccination group and the control group. Current evidence does not support the use of BCG vaccination for COVID-19 prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Biao Li, Haoran Li, Li Zhang, Yanlin Zheng
Summary: This meta-analysis of six RCTs confirmed that adalimumab (ADA) significantly reduced the risk of treatment failure or visual loss in noninfectious uveitis (NIU) patients, while moderately decreasing anterior chamber cell grades and vitreous haze grades, although leading to slightly more adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Infectious Diseases
Chih-Cheng Lai, Chao-Hsien Chen, Cheng-Yi Wang, Kuang-Hung Chen, Ya-Hui Wang, Po-Ren Hsueh
Summary: The study found that remdesivir can improve the clinical outcomes of patients with COVID-19, with a 5-day regimen likely being sufficient. However, no mortality benefit was observed with remdesivir treatment, and there was no increased risk of adverse events.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Ziqi Ye, Wenchao Yang, Bixia Xuan, Xiaofang Li, Jiana He, Haiyan Si, Wenhua Ma
Summary: Meta-analysis reveals that Sintilimab treatment in cancer can significantly improve overall survival and progression free survival, with better safety profile.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Po Huang, Xiangchun Zheng, Zhi Liu, Xiaolei Fang
Summary: This meta-analysis suggests that septic shock patients, especially those with high heart rates, may benefit from esmolol treatment. However, the positive impact of esmolol varies with the progression of septic shock, and further research is needed to determine the appropriate heart rate change interval.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Plant Sciences
Qing Wang, Guihua Xu, Yongqi Liang, Yue Xu, Yuan Zhu, Hui Ye
Summary: This study systematically evaluated the effectiveness and safety of oral Chinese herbal medicine (CHM) in the treatment of knee osteoarthritis (KOA). The results showed that CHM was more effective than placebo and Western medicine in the treatment of KOA. Additionally, the combination of CHM and Western medicine was superior to Western medicine alone. However, due to biases in the included studies and the need for further research on the effective components of Chinese medicine, a definitive conclusion on the efficacy of traditional CHM in treating KOA cannot be drawn and requires confirmation through high-quality clinical trials.
Review
Plant Sciences
Lele Yang, Wenyu Zhu, Xiaobo Zhang, Xin Zhou, Wenbin Wu, Tao Shen
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy and safety of berberine in cardiovascular diseases. The results suggested that berberine could effectively improve cardiovascular parameters with good tolerability. However, the quality of the existing research may limit the reliability of the results.
Review
Virology
Fangyuan Tian, Ruonan Yang, Zhaoyan Chen
Summary: This study systematically reviewed and synthesized the safety and efficacy of COVID-19 vaccines in children and adolescents. The findings showed that most adverse events following immunization were similar between the vaccine and placebo groups, with mild to moderate reactions being common. The investigated mRNA vaccine was found to be highly efficacious in preventing COVID-19 among children and adolescents.
JOURNAL OF MEDICAL VIROLOGY
(2022)
