Article
Microbiology
Jin Ju Park, Eun-ju Jung, Jae-Young Kim, Yu Bin Seo, Jacob Lee, Younghee Jung
Summary: This study compared the 30-day mortality rates of patients receiving Ertapenem and other carbapenems for the treatment of ESBL-producing Enterobacterales bacteremia. The results showed that there was no difference in mortality rates between Ertapenem and other carbapenems, suggesting comparable efficacy. The study also found no difference in secondary outcomes such as Clostridioides diffide infection (CDI) and the emergence of multidrug-resistant Gram-negative bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Immunology
Hiroki Namikawa, Waki Imoto, Koichi Yamada, Yoshihiro Tochino, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto
Summary: This systematic review and meta-analysis identified predictors of mortality from extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) bacteremia. Previous antimicrobial therapy, neutropenia, nosocomial infection, rapidly fatal underlying disease, respiratory tract infection, Pitt bacteremia score, severe sepsis, and urinary tract infection were found to be predictors of mortality. Appropriate empirical therapy was identified as a protective factor against mortality.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Multidisciplinary Sciences
Richard Mayanja, Adrian Muwonge, Dickson Aruhomukama, Fred Ashaba Katabazi, Mudarshiru Bbuye, Edgar Kigozi, Annettee Nakimuli, Musa Sekikubo, Christine Florence Najjuka, David Patrick Kateete
Summary: This study aimed to investigate the source of EKE organisms for neonates in a maternity ward in Uganda. The results showed evidence of transmission of drug-resistant EKE bacteria in the ward and highlighted the high prevalence of drug resistance genes. This calls for more effective infection prevention/control measures and antimicrobial stewardship programs in hospitals to reduce the spread of drug-resistant bacteria and improve patient outcomes.
Article
Immunology
Judith A. Anesi, Ebbing Lautenbach, Pranita D. Tamma, Kerri A. Thom, Emily A. Blumberg, Kevin Alby, Warren B. Bilker, Alissa Werzen, Pam Tolomeo, Jacqueline Omorogbe, Lisa Pineles, Jennifer H. Han
Summary: The study identified several risk factors for ESBL-EB BSIs among solid organ transplant recipients, including prior ESBL-EB colonization, corticosteroid-containing immunosuppression regimen, corticosteroid treatment for acute rejection, and exposure to certain antibiotics. Further studies and interventions are needed to explore and address these modifiable risk factors in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Lukas Bock, Lisandra Aguilar-Bultet, Adrian Egli, Manuel Battegay, Andreas Kronenberg, Roland Vogt, Carole Kaufmann, Sarah Tschudin-Sutter
Summary: Higher outdoor temperature may be associated with an increase in the incidence of ESBL-PE, independent of other potential confounding factors, such as antimicrobial consumption.
ENVIRONMENTAL RESEARCH
(2022)
Article
Infectious Diseases
Kelly C. Gamble, Dusten T. Rose, Julia Sapozhnikov
Summary: The study aimed to evaluate the clinical outcomes of oral step-down antibiotics compared with continued intravenous therapy in non-bacteremic urinary tract infections. The results showed no significant difference between the two treatment groups in terms of clinical failure, readmission rate, and other outcomes. However, the switch group was associated with reduced hospital length of stay and antibiotic costs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Muhammad Muqaddas Mustafai, Mavra Hafeez, Safa Munawar, Sakeenabi Basha, Ali A. Rabaan, Muhammad A. Halwani, Abdulsalam Alawfi, Amer Alshengeti, Mustafa A. Najim, Sara Alwarthan, Meshal K. AlFonaisan, Souad A. Almuthree, Mohammed Garout, Naveed Ahmed
Summary: Enterobacteriaceae have been classified as severely drug resistant bacteria by the World Health Organization due to their extensive production and dissemination of carbapenemases (CPs) and extended-spectrum beta-lactamases (ESBL). A hospital-based study was conducted to determine the prevalence of CP- and ESBL-producing Enterobacteriaceae and their antibiotic susceptibility profiles. The study found high rates of CP- and ESBL-producing Enterobacteriaceae, indicating a significant spread in the study area. The authors recommend implementing better infection prevention and control strategies and conducting nationwide screening to reduce the burden of highly resistant bugs.
Article
Microbiology
Dagninet Alelign, Aschalew Kidanewold
Summary: The study identified a significant number of multidrug-resistant ES beta L and carbapenemase-producing Enterobacteriaceae in street foods, suggesting they may be a potential source of multidrug-resistant foodborne infections. Regular examinations of street food items and tracking medication resistance trends are essential.
Article
Microbiology
Maya Frank Wolf, Raneen Abu Shqara, Karina Naskovica, Inna Amdur Zilberfarb, Inshirah Sgayer, Daniel Glikman, Hagai Rechnitzer, Vered Fleisher Sheffer, Jacob Bornstein
Summary: Maternal carriage and vertical transmission of ESBL-E pose a threat to preterm infants, leading to higher rates of complications. In this study, a correlation was found between placental inflammation and maternal ESBL-E colonization, highlighting the importance of surveillance and preventive measures.
Article
Veterinary Sciences
Mizuki Kusumoto, Tomoki Motegi, Haruna Uno, Mizuki Yokono, Kazuki Harada
Summary: This study investigated the pharmacokinetic indices of cefmetazole (CMZ) in dogs and performed pharmacokinetic-pharmacodynamic (PK-PD) analyses using Monte Carlo Simulation (MCS). The results showed that a regimen of 40 mg/kg every 6 hours of CMZ could be a viable treatment option for dogs infected with ESBL-producing Escherichia coli and Klebsiella pneumoniae.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Felicia A. Owusu, Noah Obeng-Nkrumah, Esther Gyinae, Sarkodie Kodom, Rhodalyn Tagoe, Blessing Kofi Adu Tabi, Nicholas T. K. D. Dayie, Japheth A. Opintan, Beverly Egyir
Summary: Resistance to routine antimicrobials is observed in β-lactamase-producing Gram-negative bacteria (GNB) from clinical sources. The occurrence of carbapenemases, extended-spectrum β-lactamases (ESBLs), and AmpCs genes was also detected. Escherichia coli and Klebsiella pneumoniae were the most common GNB, with 46% and 17% prevalence respectively. Multi-drug resistance (MDR) was observed in 44% of the isolates.
Article
Public, Environmental & Occupational Health
Chen Shang, Run Yang, Ya Yang, Haomin Zhang, Jianjun Zhang, Qiang Xia, Yuan Gao, Yuxiao Deng
Summary: This study investigated the colonization rate, subsequent infections, and clinical outcomes of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in liver transplantation (LT) recipients. The results showed that ESBL-E colonization was not associated with ESBL-E infection or increased risk of ESBL-GNB infection. Furthermore, ESBL-E colonization did not lead to worse prognoses when compared with non-colonized patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Yun-sun Choi, Jin-Ha Kim, Yejin Kim, Hye Jung Cho, Ji-Hee Sung, Suk-Joo Choi, Soo-Young Oh, Yae-Jean Kim, Cheong-Rae Roh
Summary: This study investigated the epidemiological changes in extended-spectrum lactamase-producing Enterobacteriaceae (ESBL-E) vaginal colonization in high-risk pregnant women and identified independent risk factors. Additionally, the study analyzed the differences in perinatal outcomes according to maternal ESBL-E vaginal colonization.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Infectious Diseases
Demissew Shenkute, Melese Hailu Legese, Berhanu Yitayew, Asaye Mitiku, Getabalew Engidaye, Saba Gebremichael, Daniel Asrat, Yimtubezinash Woldeamanuel
Summary: This study revealed a high prevalence of gastrointestinal colonization of ESBL-PE among hospitalized patients at Debre Berhan Comprehensive Hospital, with E. coli and K. pneumoniae being the predominant strains. The resistance rates to antibiotics like ampicillin were also high. History of antibiotic use, admission in neonatal intensive care unit, and presence of chronic disease were identified as independent risk factors for ESBL-PE fecal carriage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Diego Fernando Josa, Ingrid Gisell Bustos, Soad Amira Yusef, Stephanie Crevoisier, Edwin Silva, Natalia Lopez, Rafael Leal, Isabel Torres Molina, Juan Pablo Osorio, Gerson Arias, Fabian Cortes-Munoz, Carolina Sanchez, Luis Felipe Reyes
Summary: This study tested a modified protocol for the rapid detection of carbapenemase and extended-spectrum beta-lactamase producing Gram-negative bacteria. The results showed that the modified protocol had a 99% concordance rate with the traditional method and significantly reduced the identification time. This study provides novel evidence for the rapid detection of multidrug-resistant pathogens.
Editorial Material
Infectious Diseases
J. P. Stahl, E. Varon, J. P. Bru
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Dana Yelin, Charalampos D. Moschopoulos, Ili Margalit, Effrossyni Gkrania-Klotsas, Francesco Landi, Jean-Paul Stahl, Dafna Yahav
Summary: This article provides guidelines for the assessment and management of individuals with persistent symptoms after acute COVID-19 infection, including a definition for 'long COVID'. The recommendations are based on a search of literature on epidemiology, symptoms, assessment, and treatment of long COVID. However, due to insufficient evidence, only conditional guidance is provided, and further high-quality research is recommended.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Anesthesiology
Julien Picard, Jean-Noel Evain, Charlene Douron, Eloise Maussion, Xavier Stihle, Pauline Manhes, Pauline Romegoux, Aline Baron, Claire Chapuis, Celine Vermorel, Benjamin Garel, Jean-Luc Faucheron, Pierre Bouzat, Jean-Luc Bosson, Pierre Albaladejo
Summary: This study aimed to assess the impact of an interprofessional simulation-based training course on communication, teamwork, checklist adherence, and safety culture in the operating theatre. The results showed that although the rate of communication failures associated with adverse events did not significantly differ between the two periods, the overall rate of communication failures decreased. Additionally, teamwork scores and checklist adherence significantly increased after the intervention, while safety culture ratings remained unchanged.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Editorial Material
Infectious Diseases
J. P. Stahl, E. Varon, J. P. Bru
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Health Policy & Services
Claire Chapuis, Remy Collomp, Laura Albaladejo, Hugo Terrisse, Stephane Honore, Jean-Luc Bosson, Pierrick Bedouch, Pierre Albaladejo
Summary: The study aims to evaluate the changes in drug needs and distribution between anesthesia and critical care activities during the COVID-19 pandemic in France. The findings emphasize the importance of collaboration between pharmacists and anesthesiologists and intensive care physicians.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Sebastien Chanoine, Christelle Roch, Lea Liaigre, Matthieu Roustit, Celine Genty, Elisa Vitale, Jean-Luc Bosson, Christophe Pison, Benoit Allenet, Pierrick Bedouch
Summary: This study assessed the preferences of lung transplant patients and healthcare professionals regarding the use of information and communication technologies (ICTs) in therapeutic management. The results showed that phone calls, face-to-face communication, and emails were the most preferred communication tools. Patient preferences for ICTs varied, with some preferring emails for treatment changes and prescription transmission, while others preferred SMS for healthcare reminders and therapeutic management.
Article
Infectious Diseases
Paul Petitgas, Pierre Tattevin, Alexandra Mailles, Pierre Fillatre, Jean-Paul Stahl
Summary: Encephalitis in elderly patients in France has a higher incidence rate, with a higher proportion of L. monocytogenes and VZV encephalitis, increased risk of mortality and long-term effects.
Article
Immunology
Quentin Perrier, Julien Lupo, Theophile Gerster, Caroline Augier, Loic Falque, Lionel Rostaing, Laurent Pelletier, Pierrick Bedouch, Myriam Blanc, Christel Saint -Raymond, Aude Boignard, Agnes Bonadona, Johan Noble, Olivier Epaulard
Summary: This study investigated the immune response in solid-organ transplant recipients after receiving different doses of SARS-CoV-2 vaccine. The results showed that the proportion of participants with a strong humoral response increased with the number of vaccine doses. It is recommended to administer a fourth dose of vaccine to patients who did not develop an immune response after three doses.
Article
Pharmacology & Pharmacy
Quentin Perrier, Marie Piquemal, Julien Leenhardt, Luc Choisnard, Roseline Mazet, Marjorie Durand, Pierrick Bedouch
Summary: Automated compounding devices (ACD) are increasingly used for parenteral nutrition (PN) bag production, and it is important to carefully consider their acquisition and qualification. The quality by design (QbD) risk-based approach can help define the best ACD and determine critical quality attributes (CQA), which can be confirmed through tests for qualification.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Lea Picard, Alexandra Mailles, Pierre Fillatre, Pierre Tattevin, Jean-Paul Stahl
Summary: A study in France revealed that travel history is an important clue for diagnosing encephalitis. Travelers with encephalitis are younger, less likely to be immunocompromised, and more likely to experience joint pain compared to non-travelers. The main causes of encephalitis in travelers are arboviruses and Herpes simplex virus (HSV), and vaccination can help decrease the risk.
JOURNAL OF TRAVEL MEDICINE
(2023)
Review
Medicine, General & Internal
Alexiane Baloche, Claude Dussart, Pierrick Bedouch, Florence Carrouel, Gerard Mick
Summary: This scoping review aims to analyze the epidemiology and clinical burden of invasive meningococcal disease (IMD) in France by reporting epidemiological parameters and describing the clinical consequences and care pathway of patients. The incidence of IMD cases in France has fluctuated over time, with a decrease in Sg B cases and an increase in Sg W cases. The most frequently reported sequelae are severe neurological disorder, epilepsy, and anxiety, but data on sequelae and care pathways are limited.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Florence Ranchon, Sebastie Chanoine, Sophie Lambert-Lacroix, Jean -Luc Bosson, Alexandre Moreau-Gaudry, Pierrick Bedouch
Summary: This systematic review analyzed the type and quality of research publications on indirect data linkage on health product use and care trajectories in France. The results showed that data linkage was performed at both national and local levels, mainly focusing on chronic diseases and infections. The objectives of data linkage included estimating the risk of adverse drug reactions, reconstructing patient care trajectories, describing therapeutic uses, evaluating treatment benefits, and evaluating treatment adherence. However, regulatory, technical, and human constraints remain major obstacles to the deployment of health data linkage.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Infectious Diseases
J. P. Stahl, E. Canoui, P. Pavese, A. Bleibtreu, V. Dubee, T. Ferry, Y. Gillet, A. Lemaignen, M. Lorrot, J. Lourtet-Hascoet, R. Manaquin, V. Meyssonnier, T. -T Pham, E. Varon, P. Lesprit, R. Gauzit
Summary: In 2020, the French Society of Rhumatology (SFR) updated their recommendations for management of bacterial arthritis in adults. The update focuses on antibiotics with good distribution in bone and joints and emphasizes monitoring dosage according to PK/PD parameters. The recommended dosages in this update are high, especially for intravenous betalactams, and tools are provided for dosage adjustment in conditions like obesity or renal insufficiency. In cases of enterobacter infection, specialized advice from an ID physician is recommended for high dosage prescription based on antibiogram results. Oral antibiotics can be prescribed once blood cultures are sterile and clinical symptoms have improved, with treatment durations ranging from 4 weeks for most bacteria (except Neisseria: 7 days) to 6 weeks for Staphylococcus aureus.
INFECTIOUS DISEASES NOW
(2023)
Article
Infectious Diseases
J. P. Stahl, B. Castan, E. Bonnet, J. P. Bru, R. Cohen, S. Diamantis, A. Faye, H. Hitoto, N. Issa, P. Lesprit, L. Maulin, D. Poitrenaud, J. Raymond, C. Strady, E. Varon, R. Verdon, F. Vuotto, Y. Welker, R. Gauzit
INFECTIOUS DISEASES NOW
(2022)
Article
Infectious Diseases
A. Mailles, X. Argemi, C. Biron, P. Fillatre, T. De Broucker, R. Buzele, A. Gagneux-Brunon, I Gueit, C. Henry, S. Patrat-Delon, A. Makinson, E. Piet, H. Wille, M. O. Vareil, O. Epaulard, M. Martinot, P. Tattevin, J. P. Stahl
Summary: This nationwide study in France evaluated the changes in the epidemiology of encephalitis over a 10-year period. The results showed a higher proportion of identified etiologies in the more recent study. Viruses were the main causative agents, with Herpesviridae being the most common. Tuberculosis cases decreased, while tick-borne encephalitis virus and VZV cases increased compared to the 2007 study.
INFECTIOUS DISEASES NOW
(2022)
