Article
Allergy
Yuebin Wang, Shuzhen Yuan, Wei Tan, Yuanyu Zhou, Ruiyun Liao, Wei Su
Summary: The aim of this study is to investigate the effects of auraptene on inflammation and apoptosis of pneumonia cell model and uncover the mechanism involved. The results showed that auraptene promoted cell viability, inhibited cellular inflammation, and inhibited cell apoptosis. Mechanistically, auraptene inhibited the nuclear factor kappa B signaling pathway.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)
Article
Cell Biology
Feng-Feng Lv, Zheng Lian, Li-Qiu Yan, Gang Wang, Zhe Li
Summary: This study demonstrates that miR-495 attenuates endothelial cell injury and inflammation by targeting RALB in the NF-kappa B pathway, indicating its potential as a biomarker for monitoring the progression of CHD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cong Ling, Yang Yang, Xiling Hu, Meiqin Cai, Hui Wang, Chuan Chen
Summary: PNX-14 alleviates iSMCs-induced endothelial cell dysfunction in vitro.
Article
Gastroenterology & Hepatology
Shaojun Shi, Monique M. A. Verstegen, Henk P. Roest, Arif I. Ardisasmita, Wanlu Cao, Floris J. M. Roos, Petra E. de Ruiter, Marije Niemeijer, Qiuwei Pan, Jan N. M. IJzermans, Luc J. W. van der Laan
Summary: The study confirms the expression of necroptosis-related genes in cholangiocytes of patients with end-stage liver diseases, and demonstrates that the ICOs model can replicate this programmed cell death, serving as a useful tool for drug screening.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Dan Li, Menglong Wang, Jing Ye, Jishou Zhang, Yao Xu, Zhen Wang, Mengmeng Zhao, Di Ye, Jun Wan
Summary: MaR1 treatment can decrease cardiac injury in LPS-induced septic mice, improve cardiac function, reduce oxidative stress and myocardial cell apoptosis. It exerts its effects by influencing macrophage differentiation and inflammatory mediator expression.
Article
Oncology
Majid Ghorbani, Mohammad Soukhtanloo, Amir Salek Farrokhi, Seyed Mahdi Hassanian, Fatemeh Ghorbani, Amir Reza Afshari, Mohsen Taherian, Mohammad Hadi Sadeghian
Summary: This research aimed to investigate the cytotoxic effects of Auraptene on HL60 and U937 cell lines. The results showed that Auraptene decreased cellular proliferation and induced oxidative stress in HL60 and U937 cells. Additionally, Auraptene induced cell cycle arrest and apoptosis by upregulating certain proteins. These findings suggest that Auraptene may be a promising anti-tumor agent against hematologic malignancies.
Article
Cardiac & Cardiovascular Systems
Yan-Jing Zhang, Si-Si Wu, Xue-Mei Chen, Jin-Kui Pi, Yu-Fei Cheng, Yi Zhang, Xiao-Jiao Wang, Dan Luo, Jin-Han Zhou, Jia-Yi Xu, Xue Li, Zhuang Wu, Wei Jiang, Xiao-Xiao Wang
Summary: This study found that Saikosaponin D (SSD) can effectively protect cardiomyocytes from doxorubicin (DOX)-induced cardiotoxicity. SSD inhibits excessive oxidative stress and cell apoptosis by downregulating the p38-MAPK signaling pathway, providing a protective effect against DOX-induced cardiac damage.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun-jie Zhang, Shuang Wang, Xu-fei Gao, Yun-yi Hou, Jun-nan Hu, Jing-tian Zhang, Jin-gang Hou, Zi Wang, Xia Li, Wei Li
Summary: Arabinogalactan (AG), a polysaccharide, has immunomodulatory, antioxidant, and intestinal conditioning activities. This study found that AG could alleviate cisplatin-induced intestinal damage by targeting the IRE1 alpha/JNK axis to inhibit apoptosis and restore the antioxidant defense system. Thus, AG may be a potential drug to prevent cisplatin-induced intestinal toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Diqi Yang, Ruiling Yin, Qianghui Lei, Jiandi Zhu, Sha Nan, Ning Ma, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding, Yi Ding
Summary: Baicalin alleviates endometrial inflammatory injury by regulating autophagy and influencing the redistribution of TJ proteins, providing a new therapeutic approach for preventing embryo loss and endometritis.
Article
Surgery
Qiumin Xu, Jiusheng Chen, Yifan Zhu, Wenjuan Xia, Yong Liu, Jieying Xu
Summary: The results of the study indicated that JTE-013 as an antagonist of S1PR2 alleviated lung tissue injury, endothelial dysfunction, and pulmonary edema induced by sepsis. Additionally, JTE-013 reduced neutrophil count and levels of inflammatory factors.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Microbiology
David Jiao Zheng, Maria Abou Taka, Bryan Heit
Summary: Pneumonia and other inflammatory diseases of the lungs share failures in efferocytosis as a common driver of inflammation and tissue destruction. Enhancing efferocytosis can help resolve inflammatory lung diseases and restore normal lung function. Treatments like corticosteroids and statins have been found to beneficially alter efferocytic activity in patients with these diseases.
Article
Oncology
Haiye Wang, Yingyi Ma
Summary: In this study, it was found that beta-Elemene can inhibit the proliferation of oral squamous cell carcinoma cells and enhance their sensitivity to cisplatin. The main mechanism is by blocking the activation of the JAK/STAT3 signaling pathway. In addition, in vivo experiments demonstrated that the combination treatment of beta-Elemene and cisplatin can synergistically suppress tumor growth and induce cell apoptosis.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Ying Guo, Zhouzhen Li, Chen Cheng
Summary: This study found that circ_0035292 levels were elevated in infantile pneumonia (IP) and in lipopolysaccharide (LPS)-treated WI-38 cells. Knockdown of circ_0035292 alleviated LPS-induced cell injury in WI-38 cells through the miR-370-3p/TBL1XR1 axis and the NF-.B pathway.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Medicine, Research & Experimental
Ying Jin, Xueqin Chen, Zizheng Gao, Xiaofei Shen, Huangxi Fu, Zezheng Pan, Hao Yan, Bo Yang, Qiaojun He, Zhifei Xu, Peihua Luo
Summary: The study demonstrated that vandetanib could induce cutaneous toxicity by promoting apoptosis, activating autophagy, causing mitochondrial damage, and inducing DNA damage. Bisdemethoxycurcumin partially reversed vandetanib-induced keratinocyte apoptosis by activating autophagy, thereby ameliorating cutaneous toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Joyce Hou, Evelyn Tolbert, Mark Birkenbach, Nisanne S. Ghonem
Summary: This study demonstrates that treprostinil has a significant hepatoprotective effect during renal ischemia-reperfusion injury, improving liver function, antioxidant levels, suppressing inflammation, and alleviating apoptotic injury, indicating its therapeutic potential in reducing hepatic injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
