Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 62, Pages 12427-12430Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04500b
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Funding
- Danish Cancer Society
- Lundbeck Foundation (Lundbeckfoundation Fellow grant)
- Carlsberg Foundation
- Danish National Research Foundation
- Danish Research Council for Strategic Research/Natural Sciences
- Lundbeck Foundation [R105-2011-9308] Funding Source: researchfish
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We demonstrate that a unique class-defining functionality (mc-APD) found in macrocyclic natural products with potent anti-cancer activity, imparts these compounds with electrophilic reactivity. The mc-APD group represents an interesting structural hybrid between canonical biologically relevant Michael-acceptors. Further, a novel thiol-elimination method for preparation of the mc-APD group is outlined.
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