Article
Cardiac & Cardiovascular Systems
Rebecca C. Thurston, Helen E. Aslanidou Vlachos, Carol A. Derby, Elizabeth A. Jackson, Maria Mori Brooks, Karen A. Matthews, Sioban Harlow, Hadine Joffe, Samar R. El Khoudary
Summary: The study found that frequent and persistent vasomotor symptoms (VMS) are associated with increased risk of cardiovascular disease events in women.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
SunJu NamGoung, Yoosoo Chang, Yejin Kim, Hoon Kim, In Young Cho, Ria Kwon, Ga-Young Lim, Hye Rin Choi, Jeonggyu Kang, Kye-Hyun Kim, Yun Soo Hong, Di Zhao, Hyun-Young Park, Juhee Cho, Eliseo Guallar, Min-Jung Kwon, Seungho Ryu
Summary: This study investigated the relationship between AMH levels and the development of early-onset VMS among premenopausal women. The results showed that lower AMH levels were significantly associated with an increased risk of early-onset VMS. This suggests that AMH levels may play an independent role in predicting early-onset VMS among premenopausal women.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Xincheng Ji, Sydney Singleterry, Alexandra Kulikova, Yaprak Harrison, Geetha Shivakumar, E. Sherwood Brown
Summary: A study using the Dallas Heart Study dataset found that endorsement of sexual symptoms was positively associated with depressive symptom severity in menopausal women, suggesting that sexual dysfunction during menopause may predict underlying depressive symptoms.
Article
Environmental Sciences
Ryan S. Babadi, Paige L. Williams, Zhong Li, Rebecca L. Smith, Rita S. Strakovsky, Russ Hauser, Jodi A. Flaws, Tamarra James-Todd
Summary: This study examines the associations between urinary phthalate metabolite concentrations and hot flash outcomes in midlife women. The results suggest that phthalate metabolites are associated with certain hot flash outcomes, indicating that midlife may be a sensitive period for higher phthalate metabolite concentrations and menopausal symptoms.
ENVIRONMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Ki-Jin Ryu, Hyuntae Park, Jin Seol Park, Yeon Woo Lee, Soo Young Kim, Hayun Kim, Yeon Ju Lee, Tak Kim
Summary: Moderate and severe vasomotor symptoms (VMS) are independently associated with increased carotid intima-media thickness (CIMT) in otherwise healthy Korean midlife women. Clinicians managing midlife women with bothersome VMS should consider screening for subclinical cardiovascular diseases.
Article
Obstetrics & Gynecology
Wei Zhao, Jennifer A. Smith, Miao Yu, Carolyn J. Crandall, Rebecca C. Thurston, Michelle M. Hood, Edward Ruiz-Narvaez, Patricia A. Peyser, Sharon L. R. Kardia, Sioban D. Harlow
Summary: This study found that previously identified genetic factors associated with menopausal hot flashes are also related to the maintenance of hot flash symptoms, suggesting a polygenic architecture for hot flashes. Genetic influences on vasomotor symptoms vary among different racial/ethnic groups, with age at menarche in Black women and age at menopause in Chinese women being associated with frequent VMS.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Atsuo Tahara, Hajime Takamatsu, Akiyoshi Ohtake, Keiko Tanaka-Amino, Seiji Kaku
Summary: The study shows that fezolinetant can attenuate hot flash-like symptoms by inhibiting neuronal activity in the median preoptic nucleus of ovariectomized rats, and reduce hyperphagia and weight gain in menopausal rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Natalie Scime, Alison K. Shea, Peter D. Faris, Erin A. Brennand
Summary: Lifetime lactation is associated with a decreased risk and duration of frequent vasomotor symptoms. The risk of hot flashes reaches a plateau at 12 months of breastfeeding, while the risk of night sweats decreases linearly. The duration of symptoms follows a quadratic pattern, with the strongest association found at 12-18 months of breastfeeding.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Rebecca C. Thurston, Yuefang Chang
Summary: This study found that physiologically assessed vasomotor symptoms (VMS) were associated with lower levels of adiponectin, independent of factors such as age, race/ethnicity, education, insulin resistance, and waist circumference. However, adiponectin did not explain the relationship between VMS and carotid atherosclerosis.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Obstetrics & Gynecology
Makiko Tomida, Rei Otsuka, Chikako Tange, Yukiko Nishita, Tomomi Kimura, Matthias Stoelzel, Keiko Tanaka-Amino, Hiroshi Shimokata, Masakazu Terauchi
Summary: The study revealed clear associations between hot flashes and sleeping problems, even after adjusting for potential confounding factors. Women who reported hot flashes also reported worse mental and physical health than those who did not report hot flashes.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Review
Obstetrics & Gynecology
S. A. Kingsberg, R. Schulze-Rath, C. Mulligan, C. Moeller, C. Caetano, J. Bitzer
Summary: Studies have shown racial/ethnic differences in the prevalence of vasomotor symptoms (VMS), sleep disturbance and VMS treatment in menopause. Black women have the highest prevalence of VMS, while East Asian women have the lowest. White women have higher prevalence of sleep disturbance compared to other ethnic groups. White women are more likely to use hormone therapy.
Review
Nutrition & Dietetics
Ayesha Zafar Iqbal, Suet-Kei Wu, Halliru Zailani, Wei-Che Chiu, Wen-Chun Liu, Kuan-Pin Su, Shin-Da Lee
Summary: This review assesses the impact of n-3 PUFAs supplementation on vasomotor symptoms, sleep quality, and depression among postmenopausal women. The study found potential benefits of n-3 PUFAs in improving hot flashes and night sweats, but inconclusive evidence for sleep quality and depression outcomes.
Article
Environmental Sciences
Genoa R. Warner, Diana C. Pacyga, Rita S. Strakovsky, Rebecca Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: The study revealed associations between phthalates and hot flashes in midlife women, suggesting a potential impact on hot flash risk. Factors such as menopause status, BMI, race/ethnicity, and depressive symptoms may influence these associations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Herman Depypere, Christopher Lademacher, Emad Siddiqui, Graeme L. Fraser
Summary: Although international clinical practice guidelines recognize the continued role of menopausal hormone therapy (HT), concerns over safety and tolerability have led to the search for non-hormonal alternatives such as fezolinetant, a neurokinin-3 receptor (NK3R) antagonist. Fezolinetant has shown promising results in reducing VMS frequency and severity, presenting a potential non-hormonal option for menopausal symptom relief.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2021)
Review
Obstetrics & Gynecology
Veronica Djapardy, Nicholas Panay
Summary: Ovarian function starts to decline a few years before menopause, which is diagnosed retrospectively after 12 months of amenorrhea. Vasomotor symptoms and vulvovaginal atrophy during menopause can have a significant impact on women's physical and psychological well-being. This review examines the evidence, efficacy, and safety of various complementary or alternative treatments and non-hormonal pharmacological treatments for managing vasomotor symptoms and vulvovaginal atrophy in menopause.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Environmental Sciences
Caroline J. Dodd-Reynolds, Dimitris Vallis, Adetayo Kasim, Nasima Akhter, Coral L. Hanson
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Endocrinology & Metabolism
N. Akhter, K. Begum, P. Nahar, G. Cooper, D. Vallis, A. Kasim, G. R. Bentley
Summary: The study found that within the Bangladeshi community, females, married individuals, those living in London, second-generation immigrants, those with lower economic status, lower acculturation level, or lack of daily walking for at least 20 minutes were more likely to develop OR-NCDs. There are significant inter- and intra-regional disparities in OR-NCD risk among ethnic minorities in the UK, further exacerbating health inequalities.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Medicine, General & Internal
Rebecca H. Maier, Adetayo S. Kasim, Joseph Zacharias, Luke Vale, Richard Graham, Antony Walker, Grzegorz Laskawski, Ranjit Deshpande, Andrew Goodwin, Simon Kendall, Gavin J. Murphy, Vipin Zamvar, Renzo Pessotto, Clinton Lloyd, Malcolm Dalrymple-Hay, Roberto Casula, Hunaid A. Vohra, Franco Ciulli, Massimo Caputo, Serban Stoica, Max Baghai, Gunaratnam Niranjan, Prakash P. Punjabi, Olaf Wendler, Leanne Marsay, Cristina Fernandez-Garcia, Paul Modi, Bilal H. Kirmani, Mark D. Pullan, Andrew D. Muir, Dimitrios Pousios, Helen C. Hancock, Enoch Akowuah
Summary: The number of patients undergoing mitral valve repair surgery for severe mitral regurgitation is increasing, leading to debates on the adoption of minimally invasive surgical approaches. The UK Mini Mitral trial aims to provide definitive evidence on the best surgical approach and outcomes for patients, NHS, and clinical practice, informing the optimization of cost-effective practices and providing a standard for future percutaneous techniques.
Article
Anthropology
Carlye Chaney, Khurshida Begum, Alejandra Nunez-de la Mora, Lynnette L. Sievert, Shanthi Muttukrishna, Victoria Harries, Taniya Sharmeen, Lorna Murphy, Richard Gunu, Osul Chowdhury, Gillian R. Bentley
Summary: The study found that E2 levels remain stable under challenging environmental conditions, showing no significant differences among women with varying developmental conditions.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christopher D. Bayliss, Rebecca Maier, Adetayo Kasim, Helen Hancock, Enoch Akowuah
Summary: Red cell transfusion following surgical aortic valve replacement (AVR) does not appear to be associated with adverse ischemic or infective outcomes. Strict transfusion thresholds based on patient-specific factors should be maintained.
HEART LUNG AND CIRCULATION
(2021)
Review
Medicine, General & Internal
Janelle M. Wagnild, Enoch Akowuah, Rebecca H. Maier, Helen C. Hancock, Adetayo Kasim
Summary: The systematic review found limited evidence to suggest that prehabilitation is associated with increases in objectively measured physical activity, possibly due to most trials being small feasibility/pilot studies. However, significant beneficial associations were reported between objectively measured physical activity during the intervention period and health-related outcomes. Further large-scale studies with clear and consistent reporting of objective measures are needed to better understand the impact of changes in physical activity prior to surgery on surgical and health-related outcomes.
Article
Geriatrics & Gerontology
Rosemary H. M. Lim, Taniya Sharmeen, Parastou Donyai
Summary: This study investigated how people with dementia viewed and talked about their medication taking. The findings revealed that people with dementia considered medication as a lifeline and managing medications dominated their daily lives. Despite uncertainties about the effectiveness of medication, people with dementia continued to take it.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Enoch Akowuah, Ayesha Mathias, Michelle Bardgett, Samantha Harrison, Adetayo S. Kasim, Kirsti Loughran, Emmanuel Ogundimu, Jason Trevis, Janelle Wagnild, Pasan Witharana, Helen C. Hancock, Rebecca H. Maier
Summary: Prehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impact of prehabilitation in patients undergoing cardiac surgery, despite the fact these patients are generally older and have more comorbidities and frailty. This trial will assess the feasibility and impact of a prehabilitation intervention consisting of exercise and inspiratory muscle training on preoperative functional exercise capacity in adult patients awaiting elective cardiac surgery, and determine any impact on clinical outcomes after surgery.
Article
Medicine, General & Internal
Rebecca H. Maier, Chris Plummer, Adetayo S. Kasim, Nasima Akhter, Emmanuel Ogundimu, Jamie Maddox, Janine Graham, Michael Stewart, Andrew Wardley, Sophie Haney, Sharareh Vahabi, Helen Oxenham, Alison Humphreys, Nicola Cresti, Mark Verrill, Richard Graham, Lisa Chang, Helen C. Hancock, David Austin
Summary: The PROACT trial aims to determine the effectiveness of the ACE inhibitor enalapril in preventing cardiotoxicity in breast cancer and non-Hodgkin's lymphoma patients receiving anthracycline-based chemotherapy. The trial will recruit 106 participants and evaluate the release of cardiac troponin T during anthracycline treatment and 1 month after the last dose.
Article
Anthropology
Gillian R. Bentley, Alejandra Nunez-de la Mora, Michele C. Freed, Khurshida Begum, Shanthi Muttukrishna, Taniya Sharmeen, Lorna Murphy, Robert T. T. Chatterton, Osul Chowdhury, Richard Gunu, Lynnette Leidy Sievert
Summary: Recent studies have investigated the effects of social relationships on female reproductive steroid hormones, specifically estradiol and progesterone. While the results for these hormones have been mixed, there is consistent evidence that partnered women and women with young children have lower levels of testosterone. This study aimed to explore the associations between estradiol and progesterone with partnership and parity among South Asian and white British women, but the hypotheses were not supported. Further longitudinal studies are needed to understand the independent relationships between social factors and female reproductive steroid hormones.
HUMAN NATURE-AN INTERDISCIPLINARY BIOSOCIAL PERSPECTIVE
(2023)
Article
Nutrition & Dietetics
Lynnette Leidy Sievert, Taniya Sharmeen, Khurshida Begum, Shanthi Muttukrishna, Osul Chowdhury, Gillian R. Bentley
Summary: This study examined the relationship between diet and menopausal symptoms in Bangladeshi women living in Sylhet and London. The findings showed that increased consumption of phytoestrogens and lignans was associated with higher likelihood of hot flashes, while higher consumption of phytoestrogens, lignans, and isoflavones was associated with lower likelihood of vaginal dryness. Night sweats and trouble sleeping were not influenced by phytoestrogen intake.
Article
Education & Educational Research
Akansha Singh, Germaine Uwimpuhwe, Mengchu Li, Jochen Einbeck, Steve Higgins, Adetayo Kasim
Summary: In education, the impact of intervention in multisite trials may vary between schools, but most analytical models ignore this school dependency. Multilevel models address this limitation by incorporating school-specific heterogeneity, which inflates confidence intervals for effect size. Ignoring intervention variation between schools can impact interpretation and conclusions of multisite trials.
INTERNATIONAL JOURNAL OF RESEARCH & METHOD IN EDUCATION
(2022)
Article
Public, Environmental & Occupational Health
Simon Mariwah, Albert Machistey Abane, Samuel Asiedu Owusu, Adetayo Kasim, Elsbeth Robson, Michele Castelli, Kate Hampshire
Summary: While scaling up 'formal mhealth' remains a challenge in Ghana, the study found that almost all CHNs are utilizing their personal mobile phones 'informally' to bridge healthcare gaps, showcasing opportunities for promoting (or formalizing) 'informal' mhealth. Despite practical challenges in the use of personal mobile phones, addressing them can ensure sustainable healthcare delivery in the country.
GLOBAL PUBLIC HEALTH
(2022)
Article
Education & Educational Research
Germaine Uwimpuhwe, Akansha Singh, Steve Higgins, Adetayo Kasim
Summary: Educational researchers recommend using effect size and confidence intervals instead of p-values to assess intervention effectiveness. The study suggests using posterior probability as a simple metric to determine whether an intervention is effective.
INTERNATIONAL JOURNAL OF RESEARCH & METHOD IN EDUCATION
(2021)
Article
Health Care Sciences & Services
Rebecca Maier, Bilal Bawamia, Karim Bennaceur, Sarah Dunn, Leanne Marsay, Roland Amoah, Adetayo Kasim, Andrew Filby, David Austin, Helen Hancock, Ioakim Spyridopoulos
JMIR RESEARCH PROTOCOLS
(2020)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.
